Featured Publications
Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis
Wang P, Yang X, Zhang L, Sha S, Huang J, Peng J, Gu J, Pearson J, Hu Y, Zhao H, Wong F, Wang Q, Wen L. Tlr9 deficiency in B cells leads to obesity by promoting inflammation and gut dysbiosis. Nature Communications 2024, 15: 4232. PMID: 38762479, PMCID: PMC11102548, DOI: 10.1038/s41467-024-48611-8.Peer-Reviewed Original ResearchConceptsToll-like receptor 9Gut microbiotaGut microbial communityTransferred to germ-free miceB cellsGerm-free miceTLR9 deficiencyKO miceGene sequencesGerminal center B cellsMicrobial communitiesMarginal zone B cellsGut dysbiosisFollicular helper cellsSelf-DNAMetabolic homeostasisAssociated with increased frequencyPro-inflammatory stateFat tissue inflammationGutHigh-fat dietMicrobiotaHelper cellsT cellsControl mice
2022
Chronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice
Zhang Y, Luo H, Niu Y, Yang X, Li Z, Wang K, Bi H, Pang X. Chronic intermittent hypoxia induces gut microbial dysbiosis and infers metabolic dysfunction in mice. Sleep Medicine 2022, 91: 84-92. PMID: 35286865, DOI: 10.1016/j.sleep.2022.02.003.Peer-Reviewed Original ResearchConceptsObstructive sleep apneaCo-abundance groupsChronic intermittent hypoxiaIntermittent hypoxiaSystemic inflammationGut microbiotaGut microbiomeElevated systemic inflammationAdverse metabolic outcomesGut microbial dysbiosisMale C57BL/6 micePrevalent sleep disorderFatty acid metabolismIH miceIH exposureMetabolic riskSleep apneaC57BL/6 miceMicrobial dysbiosisComposition of microbiotaMetabolic outcomesIntestinal microbial communityMetabolism disordersMetabolic dysfunctionSleep disorders
2019
Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice
Zhai R, Xue X, Zhang L, Yang X, Zhao L, Zhang C. Strain-Specific Anti-inflammatory Properties of Two Akkermansia muciniphila Strains on Chronic Colitis in Mice. Frontiers In Cellular And Infection Microbiology 2019, 9: 239. PMID: 31334133, PMCID: PMC6624636, DOI: 10.3389/fcimb.2019.00239.Peer-Reviewed Original ResearchMeSH KeywordsAkkermansiaAnimalsAnti-Inflammatory AgentsCD4-Positive T-LymphocytesChronic DiseaseColitisColonCytokinesDextran SulfateDisease Models, AnimalDysbiosisFecesGastrointestinal MicrobiomeHT29 CellsHumansInterferon-gammaInterleukin-8MaleMiceMice, Inbred C57BLProbioticsRNA, Ribosomal, 16STumor Necrosis Factor-alphaVerrucomicrobiaWhole Genome SequencingConceptsInflammatory bowel diseaseAnti-inflammatory propertiesAnti-inflammatory effectsChronic colitisInflammation indexSpleen weightGut microbiotaBeneficial effectsSimilar anti-inflammatory propertiesColon histological scoresDifferentiation of TregsDextran sulfate sodiumPro-inflammatory cytokinesT cell populationsIL-8 productionColon of micePotential beneficial effectsShort-chain fatty acidsBowel diseaseIntestinal dysbiosisSulfate sodiumClinical parametersHT-29 cellsHistological scoresStrain-specific characteristics