2021
Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites
Li Y, Yang X, Zhang J, Jiang T, Zhang Z, Wang Z, Gong M, Zhao L, Zhang C. Ketogenic Diets Induced Glucose Intolerance and Lipid Accumulation in Mice with Alterations in Gut Microbiota and Metabolites. MBio 2021, 12: 10.1128/mbio.03601-20. PMID: 33785628, PMCID: PMC8092315, DOI: 10.1128/mbio.03601-20.Peer-Reviewed Original ResearchConceptsKetogenic dietGut microbiotaProportion of fatLipid metabolismGlucose intoleranceInsulin resistanceFat accumulationMouse trialsNeurodegenerative diseasesLipid accumulationMore fat accumulationInduced glucose intoleranceLipid metabolism disordersAffected lipid metabolismMetabolism disordersMetabolic disordersGlucose homeostasisGlucose metabolismSource of fatHuman studiesHigh fatTreatment of diseasesMiceBeneficial effectsWeight lossThe effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice
Zhang Z, Chen X, Loh Y, Yang X, Zhang C. The effect of calorie intake, fasting, and dietary composition on metabolic health and gut microbiota in mice. BMC Biology 2021, 19: 51. PMID: 33740961, PMCID: PMC7977615, DOI: 10.1186/s12915-021-00987-5.Peer-Reviewed Original ResearchConceptsHigh-fat dietAd libitum groupMetabolic healthGut microbiotaIntermittent fastingNormal chow miceTotal energy intakeGut microbiota modulationDietary structureIF regimenMetabolic ameliorationNormal chowCR regimenMicrobiota modulationFood intakeDietary regimensCalorie intakeCR groupCR miceRegimenControl groupEnergy intakeGut microbial communityLipid metabolismFasting-refeeding cycle
2015
Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes
Wang Q, Wang S, Yang X, You P, Zhang W. Myricetin suppresses differentiation of 3 T3-L1 preadipocytes and enhances lipolysis in adipocytes. Nutrition Research 2015, 35: 317-327. PMID: 25724338, DOI: 10.1016/j.nutres.2014.12.009.Peer-Reviewed Original ResearchMeSH Keywords3T3-L1 CellsAdipocytesAdipogenesisAnimalsAnti-Obesity AgentsCarrier ProteinsCCAAT-Enhancer-Binding Protein-betaCCAAT-Enhancer-Binding ProteinsCell DifferentiationCell SurvivalDown-RegulationFlavonoidsLipaseLipid MetabolismLipolysisLipoprotein LipaseMiceMitogen-Activated Protein KinasesPerilipin-1PhosphoproteinsPhosphorylationPPAR gammaRNA, MessengerSignal TransductionSterol EsteraseTriglyceridesConceptsJun N-terminal kinaseExtracellular signal-regulated kinaseT3-L1 preadipocytesN-terminal kinaseSignal-regulated kinaseTranscription factorsAdipogenesis-related transcription factorsT3-L1T3-L1 adipocytesAdipogenic transcription factorsGlucose transporter 4Phosphorylation of extracellular signal-regulated kinasePhosphorylation levels of extracellular signal-regulated kinaseDifferentiation of preadipocytesAdipocyte protein 2Levels of extracellular signal-regulated kinasePerilipin APeroxisome proliferator-activated receptor gAdipocyte differentiationDose-dependent increaseTransporter 4Adipocyte lipolysisPhosphorylation levelsProtein AMYR treatment