2019
The SGLT2 inhibitor dapagliflozin attenuates the activity of ROS-NLRP3 inflammasome axis in steatohepatitis with diabetes mellitus.
Leng W, Wu M, Pan H, Lei X, Chen L, Wu Q, Ouyang X, Liang Z. The SGLT2 inhibitor dapagliflozin attenuates the activity of ROS-NLRP3 inflammasome axis in steatohepatitis with diabetes mellitus. Annals Of Translational Medicine 2019, 7: 429. PMID: 31700865, PMCID: PMC6803170, DOI: 10.21037/atm.2019.09.03.Peer-Reviewed Original ResearchHFD/streptozotocinHigh-fat dietDiabetes mellitusExperimental steatohepatitisHepatic damageNOD-like receptor family pyrin domainSodium-glucose cotransporter 2 inhibitorsGlucose cotransporter 2 inhibitorsDiabetic liver injuryEfficacy of dapagliflozinROS-NLRP3 inflammasomeSGLT2 inhibitor dapagliflozinHepatic reactive oxygen speciesCotransporter 2 inhibitorsReactive oxygen speciesFamily pyrin domainHepatic lipid accumulationSterile inflammatory responseMajor clinical consequencesDAPA treatmentDM patientsInhibitor dapagliflozinLiver injuryLiver diseaseLiver steatosisThe Reduced Expression of EOLA1 May Be Related to Refractory Diabetic Foot Ulcer
Wu M, Leng W, Pan H, Lei X, Chen L, Ouyang X, Liang Z. The Reduced Expression of EOLA1 May Be Related to Refractory Diabetic Foot Ulcer. Mediators Of Inflammation 2019, 2019: 6705424. PMID: 31007603, PMCID: PMC6441532, DOI: 10.1155/2019/6705424.Peer-Reviewed Original ResearchConceptsDiabetic foot ulcersCourse of diseaseInterleukin-6Diabetes mellitusFoot ulcersWound groupChronic diabetic foot ulcersChronic wound groupsReduced expressionUncontrolled chronic inflammationRelevant clinical dataExpression of NFResults of immunofluorescenceChronic inflammationInflammatory pathwaysIntractable complicationClinical dataImmunohistochemical stainingRefractory woundsInflammatory regulationInflammationUlcersPatientsAW groupUncontrolled activation
2014
Effect of osteopontin in regulating bone marrow mesenchymal stem cell treatment of skin wounds in diabetic mice
Meng H, Wang Z, Wang W, Li W, Wu Q, Lei X, Ouyang X, Liang Z. Effect of osteopontin in regulating bone marrow mesenchymal stem cell treatment of skin wounds in diabetic mice. Diabetes/Metabolism Research And Reviews 2014, 30: 457-466. PMID: 24827928, DOI: 10.1002/dmrr.2566.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCell MovementCells, CulturedDiabetes Mellitus, ExperimentalFetal Stem CellsGreen Fluorescent ProteinsMaleMesenchymal Stem Cell TransplantationMesenchymal Stem CellsMice, Inbred C57BLMice, KnockoutMice, TransgenicMicrovesselsNeovascularization, PhysiologicOsteopontinRandom AllocationRecombinant Fusion ProteinsSkinWound HealingWounds, PenetratingConceptsWT mesenchymal stem cellsMesenchymal stem cellsHealing timeNormal miceDiabetic miceSkin woundsBone marrow mesenchymal stem cell treatmentMesenchymal stem cell treatmentStem cellsWestern blottingHealing woundsKO male miceWild-type miceWounds of miceDiabetic skin woundsRole of osteopontinStem cell treatmentEffect of osteopontinExpression of osteopontinBacks of miceDiabetes mellitusIntraperitoneal injectionMale miceMicrovessel densityTail vein
2013
Effect of laparoscopic Roux-en-Y gastric bypass surgery on type 2 diabetes mellitus with hypertension: A randomized controlled trial
Liang Z, Wu Q, Chen B, Yu P, Zhao H, Ouyang X. Effect of laparoscopic Roux-en-Y gastric bypass surgery on type 2 diabetes mellitus with hypertension: A randomized controlled trial. Diabetes Research And Clinical Practice 2013, 101: 50-56. PMID: 23706413, DOI: 10.1016/j.diabres.2013.04.005.Peer-Reviewed Original ResearchConceptsType 2 diabetes mellitusGastric bypass surgeryUsual careGroup CLaparoscopic RouxRYGB surgeryBypass surgeryDiabetes mellitusGroup ACardiac structure/functionDiabetes remissionExenatide therapyHypertensive peopleInflammation indexAntihypertensive drugsObese T2DMInflammatory cytokinesMetabolic panelCardiovascular functionGroup BMetabolic parametersObese peopleCardiac structureSurgeryHypertension