1985
Abnormal coagulation results in patients with hodgkin's disease
Seifter E, Parker R, Gralnick H, Wesley M, DeVita V, Young R, Longo D. Abnormal coagulation results in patients with hodgkin's disease. The American Journal Of Medicine 1985, 78: 942-950. PMID: 3160235, DOI: 10.1016/0002-9343(85)90216-5.Peer-Reviewed Original ResearchConceptsHodgkin's diseaseProthrombin timeAbnormal coagulation test resultsAbnormal coagulation resultsAbnormal test valuesComplete staging evaluationProthrombin time prolongationCoagulation test resultsCourse of diseaseCoagulation factor disordersPartial thromboplastin timeAlkaline phosphatase levelsClotting abnormalitiesAdvanced diseaseConstitutional symptomsMediastinal involvementStaging evaluationCoagulation abnormalitiesAbnormal coagulationEvaluable casesTumor regressionThromboplastin timeFactor disordersHematologic testingInvasive procedures
1980
General Progress in Clinical Chemotherapy of Advanced Disease
Muggia F, Henney J, DeVita V. General Progress in Clinical Chemotherapy of Advanced Disease. Recent Results In Cancer Research 1980, 74: 1-7. PMID: 7003657, DOI: 10.1007/978-3-642-81488-4_1.Peer-Reviewed Original ResearchConceptsAggressive systemic treatmentMinimal residual diseaseTumor cell cytotoxicityAdvanced diseaseImmunologic factorsSystemic treatmentLocal therapyAdvanced cancerTumor burdenResidual diseaseTumor controlCurative approachLocoregional drug deliveryClinical chemotherapySuccessful chemotherapyEffective drugsDrug pharmacologyCell cytotoxicityInfectious diseasesDiseaseChemotherapyCancerCurrent resultsCellular heterogeneityTherapy
1979
Chemotherapy of Hodgkin's disease
Young R, DeVita V. Chemotherapy of Hodgkin's disease. Clinics In Haematology 1979, 8: 625-644. PMID: 91466, DOI: 10.1016/s0308-2261(79)80007-7.Peer-Reviewed Original ResearchConceptsAdvanced diseaseHodgkin's diseaseModality approachSuch long-term complicationsIIIB Hodgkin's diseaseInduction chemotherapy regimensPrimary induction failureShort initial remissionAdvanced Hodgkin's diseaseDisease-free survivalOverall survival ratePrognosis of patientsLong-term complicationsInduction failureAggressive therapyChemotherapy regimensComplete remissionInitial remissionLate complicationsSecond malignanciesCombination chemotherapySurvival benefitMOPP regimenActual survivalCombined modalityMultimodal primary cancer treatment (adjuvant chemotherapy): current results and future prospects.
Weiss R, DeVita V. Multimodal primary cancer treatment (adjuvant chemotherapy): current results and future prospects. Annals Of Internal Medicine 1979, 91: 251-60. PMID: 380437, DOI: 10.7326/0003-4819-91-2-251.Peer-Reviewed Original ResearchConceptsDisease-free survivalPrimary treatment programGroup of patientsAdvanced diseaseTherapy regimensPrimary lesionSurgical removalAdult malignanciesPalliative treatmentTreatment resultsClinical trialsHuman trialsCancer mortalityChemotherapyMalignancyTreatment programsTreatmentRegimensPatientsLesionsCancerCentral nervous system complications of non-Hodgkin's lymphoma The potential role for prophylactic therapy
Young R, Howser D, Anderson T, Fisher R, Jaffe E, DeVita V. Central nervous system complications of non-Hodgkin's lymphoma The potential role for prophylactic therapy. The American Journal Of Medicine 1979, 66: 435-443. PMID: 433950, DOI: 10.1016/0002-9343(79)91065-9.Peer-Reviewed Original ResearchConceptsCentral nervous systemCNS diseaseHodgkin's lymphomaCentral nervous system complicationsNervous system complicationsWhole-brain irradiationGood clinical responseBone marrow involvementTime of diagnosisGroup of patientsAdvanced diseaseBrain irradiationClinical remissionCNS prophylaxisIntrathecal chemotherapyLymphomatous meningitisProphylactic therapyClinical responseMarrow involvementPositive cytologyMalignant lymphomaSystem complicationsLumbar punctureNodular lymphomaRisk factors
1978
Advanced Ovarian Adenocarcinoma — A Prospective Clinical Trial of Melphalan (L-PAM) versus Combination Chemotherapy
Young R, Chabner B, Hubbard S, Fisher R, Bender R, Anderson T, Simon R, Canellos G, DeVita V. Advanced Ovarian Adenocarcinoma — A Prospective Clinical Trial of Melphalan (L-PAM) versus Combination Chemotherapy. New England Journal Of Medicine 1978, 299: 1261-1266. PMID: 101843, DOI: 10.1056/nejm197812072992301.Peer-Reviewed Original ResearchConceptsAdvanced ovarian adenocarcinomaFour-drug combinationOverall response rateOvarian adenocarcinomaComplete remissionMedian survivalResidual diseaseResponse rateHigher overall response rateExtensive residual diseaseFour-drug regimenProspective clinical trialsLonger median survivalMinimal residual diseaseAdvanced diseaseCombination chemotherapyClinical trialsSevere toxicityMelphalanPatientsAdenocarcinomaDiseaseRemissionTrialsSurvivalSequential nonsurgical and surgical staging of non‐Hodgkin's lymphoma
Chabner B, Johnson R, Young R, Canellos G, Hubbard S, Johnson S, Devita V. Sequential nonsurgical and surgical staging of non‐Hodgkin's lymphoma. Cancer 1978, 42: 922-925. PMID: 150938, DOI: 10.1002/1097-0142(197808)42:2+<922::aid-cncr2820420714>3.0.co;2-9.Peer-Reviewed Original Research
1976
Perspectives on research in gynecologic oncology. Treatment protocols
Devita V, Wasserman T, Young R, Carter S. Perspectives on research in gynecologic oncology. Treatment protocols. Cancer 1976, 38: 509-525. PMID: 776390, DOI: 10.1002/1097-0142(197607)38:1<509::aid-cncr2820380175>3.0.co;2-a.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinomaAgedAlkylating AgentsAntineoplastic AgentsCarcinoma, Squamous CellClinical Trials as TopicDrug EvaluationDrug Therapy, CombinationFemaleGenital Neoplasms, FemaleHumansHysterectomyMiddle AgedNeoplasm Recurrence, LocalOvarian NeoplasmsProgestinsUterine Cervical NeoplasmsUterine NeoplasmsConceptsClinical trialsOvarian cancerAdvanced uterine cancerPostoperative adjuvant chemotherapyStage II diseaseMetastatic cervical cancerEffective adjuvant treatmentEffect of radiotherapyUse of adriamycinUse of hydroxyureaCombination of drugsL-phenylalanine mustardPathways of spreadMore effective drugsAdjuvant chemotherapyInoperable diseaseResectable tumorsAdjuvant treatmentAdvanced diseasePostoperative radiotherapySystemic chemotherapyGynecologic malignanciesSystemic treatmentTreatment failureUterine cervix
1975
Peritoneoscopy: a valuable staging tool in ovarian carcinoma.
Rosenoff S, Young R, Anderson T, Bagley C, Chabner B, Schein P, Hubbard S, DeVita V. Peritoneoscopy: a valuable staging tool in ovarian carcinoma. Annals Of Internal Medicine 1975, 83: 37-41. PMID: 125057, DOI: 10.7326/0003-4819-83-1-37.Peer-Reviewed Original ResearchConceptsOvarian carcinomaApparent clinical remissionValuable staging toolAdvanced diseaseClinical remissionExploratory laparotomyConsecutive patientsDiaphragmatic involvementPretreatment evaluationAbdominal radiotherapyTherapeutic failureLaboratory examinationsStaging toolPatientsCarcinomaLiver areaLaparotomyPeritoneoscopySecond lookPercentRemissionRadiotherapyRoentgenologicTherapyPelvis
1973
Hodgkin's Disease in Childhood
Young R, DeVita V, Johnson R. Hodgkin's Disease in Childhood. Blood 1973, 42: 163-174. PMID: 4793108, DOI: 10.1182/blood.v42.2.163.163.Peer-Reviewed Original ResearchCombination Chemotherapy and Survival in Advanced Hodgkin's Disease
Canellos G, Young R, Berard C, DeVita V. Combination Chemotherapy and Survival in Advanced Hodgkin's Disease. JAMA Internal Medicine 1973, 131: 388-390. PMID: 4569375, DOI: 10.1001/archinte.1973.00320090078008.Peer-Reviewed Original Research
1970
Abnormalities of Tryptophan Metabolism and Plasma Pyridoxal Phosphate in Hodgkin's Disease
Chabner B, DeVita V, Livingston D, Oliverio V. Abnormalities of Tryptophan Metabolism and Plasma Pyridoxal Phosphate in Hodgkin's Disease. New England Journal Of Medicine 1970, 282: 838-843. PMID: 5418547, DOI: 10.1056/nejm197004092821504.Peer-Reviewed Original ResearchConceptsHodgkin's diseaseUntreated patientsPlasma levelsPlasma pyridoxal phosphate levelsPlasma pyridoxal phosphatePyridoxal phosphate levelsAdvanced diseaseComplete remissionSymptomatic diseaseImmunosuppressive effectsAbnormal resultsPyridoxine deficiencyNormal limitsTryptophan metabolismPatientsDiseasePyridoxal phosphatePhosphate levelsDeficiencyL-tryptophanLittle evidenceMetabolismRemissionChemotherapyAnemia