2019
In vivo, ex vivo and in vitro evidence for atropine-mediated attenuation of glucagon-like peptide-1 secretion: findings from a systematic review
Rathish D, Agampodi S, Jayasumana C. In vivo, ex vivo and in vitro evidence for atropine-mediated attenuation of glucagon-like peptide-1 secretion: findings from a systematic review. Environmental Science And Pollution Research 2019, 26: 29597-29605. PMID: 31446595, DOI: 10.1007/s11356-019-06227-2.Peer-Reviewed Original ResearchConceptsGlucagon-like peptide-1GLP-1 secretionGlucagon-like peptide-1 secretionDipeptidyl peptidase-4 (DPP-4) enzymeRole of atropineVivo studiesPeptide-1 secretionRisk of biasPostprandial glucose homeostasisEx vivo studyPostprandial secretionCholinergic pathwaysAnticholinergic agentsCochrane LibraryHealthy menMuscarinic receptorsGlucose homeostasisPeptide-1Reference listsCompetitive antagonistHuman studiesAnimal studiesPRISMA statementSystematic reviewAtropine
2018
A low GLP-1 response among patients treated for acute organophosphate and carbamate poisoning: a comparative cross-sectional study from an agrarian region of Sri Lanka
Rathish D, Senavirathna I, Jayasumana C, Agampodi S, Siribaddana S. A low GLP-1 response among patients treated for acute organophosphate and carbamate poisoning: a comparative cross-sectional study from an agrarian region of Sri Lanka. Environmental Science And Pollution Research 2018, 26: 2864-2872. PMID: 30499084, DOI: 10.1007/s11356-018-3818-9.Peer-Reviewed Original ResearchMeSH KeywordsAcetylcholinesteraseAcute DiseaseAdultAtropineCarbamatesChronic DiseaseCross-Sectional StudiesDiabetes Mellitus, Type 2Dose-Response Relationship, DrugErythrocytesFemaleGlucagon-Like Peptide 1HumansIncidenceIncretinsInsecticidesMaleMiddle AgedOccupational ExposureOrganophosphate PoisoningSri LankaConceptsGLP-1 responseComparative cross-sectional studyRBC-AChE activityCross-sectional studyAcute organophosphateControl groupAcute groupLower GLP-1 responseRed blood cell acetylcholinesterase activityGLP-1 pathwayAcetylcholinesterase inhibitor insecticidesAtropine therapyChronic groupCarbamate poisoningGLP-1High incidenceType 2PatientsAcetylcholinesterase activityInhibitor insecticidesPoisoningGroupResponseMin valuesDiabetes
2016
From organophosphate poisoning to diabetes mellitus: The incretin effect
Rathish D, Agampodi SB, Jayasumana MACS, Siribaddana SH. From organophosphate poisoning to diabetes mellitus: The incretin effect. Medical Hypotheses 2016, 91: 53-55. PMID: 27142144, DOI: 10.1016/j.mehy.2016.04.002.Peer-Reviewed Original ResearchConceptsAccumulation of acetylcholineIncretin effectGlucose homeostasisDiabetes mellitusOP poisoningType 2 diabetes mellitusPeptide-1 secretionAcute OPMuscarinic receptorsTreatment modalitiesOrganophosphate poisoningPositive findingsInhibition of acetylcholinesterasesMellitusInduced disruptionHomeostasisPoisoningInhibitionDisruptionT2DMAcetylcholineGlucagonIncidenceSecretionReceptors