2014
Regional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011
Agampodi SB, Dahanayaka NJ, Bandaranayaka AK, Perera M, Priyankara S, Weerawansa P, Matthias MA, Vinetz JM. Regional Differences of Leptospirosis in Sri Lanka: Observations from a Flood-Associated Outbreak in 2011. PLOS Neglected Tropical Diseases 2014, 8: e2626. PMID: 24454971, PMCID: PMC3894175, DOI: 10.1371/journal.pntd.0002626.Peer-Reviewed Original ResearchConceptsOutbreak of leptospirosisClinical presentationAcute renal failureDifferent clinical presentationsCross-sectional studyMedian bacterial loadPublic health interventionsPublic health relevanceLeptospira interrogans serovar laiRenal failureSevere thrombocytopeniaInfectious disease epidemicsDifferent Leptospira speciesEtiological causesImportant causeHealth interventionsHealth relevanceLeptospirosisTropical diseasesBacterial loadLeptospira kirschneriLeptospirosis outbreaksSerovar laiLeptospira speciesL. kirschneri
2012
Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka
Agampodi SB, Matthias MA, Moreno AC, Vinetz JM. Utility of Quantitative Polymerase Chain Reaction in Leptospirosis Diagnosis: Association of Level of Leptospiremia and Clinical Manifestations in Sri Lanka. Clinical Infectious Diseases 2012, 54: 1249-1255. PMID: 22354922, PMCID: PMC3404689, DOI: 10.1093/cid/cis035.Peer-Reviewed Original ResearchConceptsQuantitative polymerase chain reactionClinical manifestationsPolymerase chain reactionBlood samplesChain reactionWhole bloodOnset of symptomsSensitivity of qPCRAssociation of levelsSerum/bloodMicroscopic agglutination test panelValid diagnostic testPatient blood samplesOptimal sample typeFailure patientsRenal failureWhole blood samplesPatient populationTimely diagnosisLeptospiral loadEndemic areasDay 2Day 15LeptospiremiaDiagnostic testsPredictors of the development of myocarditis or acute renal failure in patients with leptospirosis: An observational study
Dassanayake D, Wimalaratna H, Nandadewa D, Nugaliyadda A, Ratnatunga CN, Agampodi SB. Predictors of the development of myocarditis or acute renal failure in patients with leptospirosis: An observational study. BMC Infectious Diseases 2012, 12: 4. PMID: 22243770, PMCID: PMC3292442, DOI: 10.1186/1471-2334-12-4.Peer-Reviewed Original ResearchConceptsAcute renal failureRenal failureClinical featuresMicroscopic agglutination testOdds ratioTeaching hospitalExact testComplication of leptospirosisDevelopment of myocarditisLaboratory measuresCommon clinical featuresVaried clinical presentationsProspective descriptive studyPredictors of severityFisher's exact testMann-Whitney U testLogistic regression modelsPain 6ResultsSixty-twoLaboratory parametersClinical presentationLaboratory variablesLaboratory predictorsLeptospirosis patientsCase definition
2011
Leptospirosis Outbreak in Sri Lanka in 2008: Lessons for Assessing the Global Burden of Disease
Agampodi SB, Peacock SJ, Thevanesam V, Nugegoda DB, Smythe L, Thaipadungpanit J, Craig SB, Burns MA, Dohnt M, Boonsilp S, Senaratne T, Kumara A, Palihawadana P, Perera S, Vinetz JM. Leptospirosis Outbreak in Sri Lanka in 2008: Lessons for Assessing the Global Burden of Disease. American Journal Of Tropical Medicine And Hygiene 2011, 85: 471-478. PMID: 21896807, PMCID: PMC3163869, DOI: 10.4269/ajtmh.2011.11-0276.Peer-Reviewed Original ResearchConceptsAcute renal failureLeptospirosis outbreaksCase fatality rateLimited diagnostic capacityDisease burden estimatesLaboratory diagnostic capabilitiesEndemic infectious diseasesCause of epidemicSerovars PyrogenesClinical characteristicsRenal failureHeart failurePatient populationMain complicationsCase definitionBurden estimatesGlobal burdenCase confirmationHigh titersInfectious diseasesDiagnostic capacityHigh endemicityReference groupLeptospira interrogansDisease