A Protocol for the Study of Polymorphisms and Response to Metformin in Patients with Type 2 Diabetes in Trinidad.
Clement Y, Singh S, Motilal S, Maharaj R, Nunez-Smith M. A Protocol for the Study of Polymorphisms and Response to Metformin in Patients with Type 2 Diabetes in Trinidad. Ethnicity & Disease 2020, 30: 211-216. PMID: 32269463, PMCID: PMC7138437, DOI: 10.18865/ed.30.s1.211.Peer-Reviewed Original ResearchConceptsType 2 diabetesMetformin monotherapyPrimary health care facilitiesGenotype frequenciesHealth care facilitiesHealth Authority regionMedication initiationAdherent patientsClinical responseMost patientsDiabetic patientsGlycemic controlMaximal dosesStudy populationOrganic cation transportersBlood samplesCare facilitiesPatientsMetformin responseMonotherapyDiabetesMetforminFirst choiceGenetic polymorphismsSingle nucleotide polymorphismsIs hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes?
Cohall D, Ojeh N, Ferrario CM, Adams OP, Nunez-Smith M. Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes? Journal Of The Renin-Angiotensin-Aldosterone System 2020, 21: 1470320320908186. PMID: 32089050, PMCID: PMC7036504, DOI: 10.1177/1470320320908186.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAngiotensin IAngiotensin IIAngiotensin-Converting Enzyme 2Black PeopleHumansHypertensionMiddle AgedPeptide FragmentsPeptidesPeptidyl-Dipeptidase AProto-Oncogene MasProto-Oncogene ProteinsReceptor, Angiotensin, Type 1Receptors, G-Protein-CoupledRenin-Angiotensin SystemYoung AdultConceptsRenin angiotensin aldosterone systemAngiotensin aldosterone systemAldosterone systemClinical blood pressure readingsType 2 diabetes mellitusACE2/AngEnzyme 2 activityChronic renal diseaseBlood pressure readingsVenous blood samplesAfro-Caribbean originAntihypertensive treatmentMineralocorticoid blockersPressor armDiabetes mellitusRenal diseaseReceptor axisAfrican descentUrine collectionEnzyme 2Blood samplesHypertensionPressure readingsAnthropometric dataAfrican descent populations