Morphological alteration of the pancreatic islet in ovariectomized rats fed a high-fat high-fructose diet
Chansela P, Potip B, Weerachayaphorn J, Kangwanrangsan N, Chukijrungroat N, Saengsirisuwan V. Morphological alteration of the pancreatic islet in ovariectomized rats fed a high-fat high-fructose diet. Histochemistry And Cell Biology 2022, 157: 427-442. PMID: 35037128, DOI: 10.1007/s00418-021-02062-0.Peer-Reviewed Original ResearchConceptsHigh-fat high-fructose dietHigh-fructose dietEstrogen deficiencyInsulin resistancePancreatic isletsOVX ratsWhole-body insulin resistanceExcessive caloric intakeElevated plasma glucoseInsulin-resistant statesΒ-cell dysfunctionInsulin-producing β-cellsDiabetes coexistsEstrogen replacementInsulin levelsOvariectomized ratsDiabetic statePlasma glucoseDisease progressionHistological changesPancreatic morphologyCaloric intakeFat accumulationGlucagon-producing α-cellsImmunohistochemical staining