Harlan Linver Pietz, MD, PhD
Hospital ResidentCards
About
Research
Publications
2025
Diphenhydramine overdose in an older adult with neuropsychiatric and cardiovascular comorbidities: a case report
Gu E, Sharninghausen J, Pietz H, Patel A, Persaud A, Collins E, Kerins G. Diphenhydramine overdose in an older adult with neuropsychiatric and cardiovascular comorbidities: a case report. The American Journal Of Medicine 2025 PMID: 41238147, DOI: 10.1016/j.amjmed.2025.11.006.Peer-Reviewed Original ResearchAssessing SARS-CoV-2 Rare Mutations and Transmission in New York City by NGS
Liu D, Pietz H, Rodriguez G, Wu Y, Cao Y, Singh V, Li H, Konadu E, James K, Lui C, Varghese B, Shao M, Chen G, Schreiner A, Tong J, Urban C, Prasad N, Hassoun A, Sharma M, Rodgers W. Assessing SARS-CoV-2 Rare Mutations and Transmission in New York City by NGS. Microorganisms 2025, 13: 1821. PMID: 40871324, PMCID: PMC12388554, DOI: 10.3390/microorganisms13081821.Peer-Reviewed Original ResearchWhole-genome sequencingRare mutationsNon-structural protein genesSARS-CoV-2 isolatesUnique mutational patternsMultiple viral lineagesGenomic diversityOmicron genomesSARS-CoV-2Protein geneStructural proteinsViral lineagesFrequent mutationsMutationsMutation patternsLineagesViral evolutionLocal transmission chainsImmune escapeIsolatesClinical profilePublic health significanceSequenceViral isolatesDisease severityComparative Analysis of RT-PCR and a Colloidal Gold Immunochromatographic Assay for SARS-CoV-2 Detection
Li H, Liu D, Zhou Q, Rodriguez G, Pietz H, Singh V, Konadu E, James K, Lui C, Shao M, Chen J, Schreiner A, Urban C, Truong J, Prasad N, Rodgers W. Comparative Analysis of RT-PCR and a Colloidal Gold Immunochromatographic Assay for SARS-CoV-2 Detection. Diagnostics 2025, 15: 1362. PMID: 40506934, PMCID: PMC12154499, DOI: 10.3390/diagnostics15111362.Peer-Reviewed Original ResearchGold immunochromatographic assayColloidal gold immunochromatographic assaySARS-CoV-2 detectionRT-PCRLarge-scale screeningSARS-CoV-2Immunochromatographic assayResource-limited settingsAnalysis of RT-PCRRT-PCR resultsReceiver operating characteristic curve analysisProlonged turnaround timeRT-PCR Ct valuesCalculate area under the curveArea under the curveCharacteristic curve analysisPoint-of-care applicationsPerformance of RT-PCRAlternative diagnostic toolAssayClinical parametersRT-PCR testEarly detection effortsDiagnostic performanceCurve analysisStructural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2
Koide E, Pietz H, Beltran J, Chen J. Structural basis for the transport and regulation mechanism of the multidrug resistance-associated protein 2. Nature Communications 2025, 16: 484. PMID: 39779684, PMCID: PMC11711199, DOI: 10.1038/s41467-024-55810-w.Peer-Reviewed Original ResearchConceptsAutoinhibited stateR domainPost-translocation stateSubstrate-binding sitePre-translocation stateATP-binding siteProtein 2Nucleotide-binding domain 2Cryogenic electron microscopyStructural basisDiverse array of compoundsDomain 2Cryo-EMRegulation mechanismChemotherapeutic resistanceConformational changesMultidrug resistanceArray of compoundsDiverse arrayConformational statesLiver homeostasisMultidrug resistance-associated protein 2Initial transportSubstrateCytosol
2024
Psychological stress, cardiovascular disease and somatic pain in asylum seekers: a retrospective cross-sectional study
Lurie J, Pietz H, Hatef C, Taki F, Lee A, Virk S, Oren T, Gbekie C, Milewski A, Boyer R, Kaur G. Psychological stress, cardiovascular disease and somatic pain in asylum seekers: a retrospective cross-sectional study. Nature Mental Health 2024, 2: 1442-1450. PMID: 40698314, PMCID: PMC12283149, DOI: 10.1038/s44220-024-00312-3.Peer-Reviewed Original ResearchSymptoms of psychological stressSomatic painCross-sectional studyCardiovascular diseasePsychological stressRetrospective cross-sectional studyStress symptomsCardiovascular disease symptomsChest painPain symptomsHealth outcomesCVD symptomsPainRisk factorsStroke symptomsMedical evaluationSymptomsAsylum seekersComorbidityPrevalenceComparative Analysis of Viral Load and Cytokines during SARS-CoV-2 Infection between Pregnant and Non-Pregnant Women
Liu D, Li H, Li X, Rodriguez G, Pietz H, Fiel R, Konadu E, Singh V, Loo F, Rodgers W. Comparative Analysis of Viral Load and Cytokines during SARS-CoV-2 Infection between Pregnant and Non-Pregnant Women. International Journal Of Molecular Sciences 2024, 25: 7731. PMID: 39062978, PMCID: PMC11277191, DOI: 10.3390/ijms25147731.Peer-Reviewed Original ResearchConceptsNon-pregnant womenSARS-CoV-2 infectionResponse to SARS-CoV-2 infectionPregnant womenViral loadNeutralizing antibodiesImmune response to SARS-CoV-2 infectionAnalysis of viral loadSARS-CoV-2Retrospective cohort studyIgG neutralizing antibodiesCytokine expression patternsMultiplex reverse transcription polymerase chain reactionAnti-N protein IgGExpression of leptinDifferential cytokine expressionEnhanced antibody productionReverse transcription polymerase chain reactionVulnerability of pregnant womenCytokine array assayTranscription polymerase chain reactionCytokine profileIncidence of SARS-CoV-2 infectionImmune modulationPolymerase chain reactionStructure-based discovery of CFTR potentiators and inhibitors
Liu F, Kaplan A, Levring J, Einsiedel J, Tiedt S, Distler K, Omattage N, Kondratov I, Moroz Y, Pietz H, Irwin J, Gmeiner P, Shoichet B, Chen J. Structure-based discovery of CFTR potentiators and inhibitors. Cell 2024, 187: 3712-3725.e34. PMID: 38810646, PMCID: PMC11262615, DOI: 10.1016/j.cell.2024.04.046.Peer-Reviewed Original ResearchConceptsLarge-scale dockingIon channel drug discoveryStructure-based discoveryStructure-based optimizationMedicinal chemistryTested ligandsMolecular dockingSmall moleculesDrug discoveryCystic fibrosis transmembrane conductance regulatorMoleculesAllosteric siteIonsDockingLigandSecretory diarrheaCystic fibrosisCystic fibrosis transmembrane conductance regulator modulatorsChemistryTransmembrane conductance regulatorSuboptimal pharmacokineticsCFTR potentiators
2023
A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation
Pietz H, Abbas A, Johnson Z, Oldham M, Suga H, Chen J. A macrocyclic peptide inhibitor traps MRP1 in a catalytically incompetent conformation. Proceedings Of The National Academy Of Sciences Of The United States Of America 2023, 120: e2220012120. PMID: 36893260, PMCID: PMC10089224, DOI: 10.1073/pnas.2220012120.Peer-Reviewed Original ResearchConceptsMultidrug resistance protein 1MRP1 overexpressionSubstrate transportAdenosine triphosphate-binding cassetteCatalytically incompetent conformationStructurally unrelated moleculesCpI1Small molecule inhibitorsAdenosine triphosphatePlasma membraneA-resolutionCryoelectron microscopyCryo-EMUnrelated moleculesConformational changesMultidrug resistanceMRP1 functionProtein 1Macrocyclic peptidesMultidrug transporter P-glycoproteinFlexible sidechainsXenobiotic compoundsNanomolar potencyCellular toxicityTherapeutic candidateSex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine
Cheung F, Apps R, Dropulic L, Kotliarov Y, Chen J, Jordan T, Langweiler M, Candia J, Biancotto A, Han K, Rachmaninoff N, Pietz H, Wang K, Tsang J, Cohen J. Sex and prior exposure jointly shape innate immune responses to a live herpesvirus vaccine. ELife 2023, 12: e80652. PMID: 36648132, PMCID: PMC9844983, DOI: 10.7554/elife.80652.Peer-Reviewed Original ResearchConceptsEarly innate responseVaccine recipientsPrior exposureInnate responseType I interferon signatureInfectious diseasesSeronegative vaccine recipientsType I IFN responseEarly antiviral responseNational InstituteInnate immune responseSystems immunology approachI IFN responseAdaptive immune phenotypesIntramural Research ProgramInterferon signatureAntibody titersVaccine trialsImmune phenotypeVirus vaccineNaive womenImmune responseSanofi PasteurDay 1Herpesvirus vaccine
2021
Serum and Cervicovaginal Fluid Antibody Profiling in Herpes Simplex Virus–Seronegative Recipients of the HSV529 Vaccine
Wang K, Dropulic L, Bozekowski J, Pietz H, Jegaskanda S, Dowdell K, Vogel J, Garabedian D, Oestreich M, Nguyen H, Ali M, Lumbard K, Hunsberger S, Reifert J, Haynes W, Sawyer J, Shon J, Daugherty P, Cohen J. Serum and Cervicovaginal Fluid Antibody Profiling in Herpes Simplex Virus–Seronegative Recipients of the HSV529 Vaccine. Journal Of Infectious Diseases 2021, 224: 1509-1519. PMID: 33718970, PMCID: PMC8599754, DOI: 10.1093/infdis/jiab139.Peer-Reviewed Original ResearchConceptsVaccine recipientsHSV-2Genital tractNatural killer (NK) cell activityCell activationHerpes simplex virus type 2Replication-defective vaccinesNK cell activitySerum neutralizing antibody responsesNeutralizing antibody responsesAntibodies to epitopesCervicovaginal fluidGenital infectionGenital herpesAntibody profilesNeutralization titersHSV529Antibody responseSerum antibodiesHerpesType 2GD antibodiesAntibodiesSerumVaccine