2006
Risks Associated With Statin Therapy
Kashani A, Phillips CO, Foody JM, Wang Y, Mangalmurti S, Ko DT, Krumholz HM. Risks Associated With Statin Therapy. Circulation 2006, 114: 2788-2797. PMID: 17159064, DOI: 10.1161/circulationaha.106.624890.Peer-Reviewed Original ResearchConceptsCreatine kinase elevationStatin therapyTransaminase elevationClinical trialsStatin trialsAdverse eventsHigher statin dosesMajor statin trialsRandomized statin trialsReports of myalgiaRisk of myalgiaWithdrawal of therapySevere comorbid conditionsSmall excess riskSignificant absolute increaseEnglish-language reportsHepatic complicationsStatin monotherapyCardiovascular eventsStatin dosesMost patientsComorbid conditionsAbsolute riskExcess riskElectronic search
2004
Adverse Effects of β-Blocker Therapy for Patients With Heart Failure: A Quantitative Overview of Randomized Trials
Ko DT, Hebert PR, Coffey CS, Curtis JP, Foody JM, Sedrakyan A, Krumholz HM. Adverse Effects of β-Blocker Therapy for Patients With Heart Failure: A Quantitative Overview of Randomized Trials. JAMA Internal Medicine 2004, 164: 1389-1394. PMID: 15249347, DOI: 10.1001/archinte.164.13.1389.Peer-Reviewed Original ResearchMeSH KeywordsAdrenergic beta-AntagonistsAgedBisoprololBradycardiaCarbazolesCarvedilolDizzinessFatigueFemaleFollow-Up StudiesHeart Conduction SystemHeart FailureHumansHypotensionMaleMetoprololMiddle AgedPropanolaminesRisk FactorsRisk Reduction BehaviorSeverity of Illness IndexStatistics as TopicTreatment FailureVentricular Dysfunction, LeftWithholding TreatmentConceptsBeta-blocker therapyHeart failureAdverse effectsLeft ventricular systolic dysfunctionBeta-blocker trialsCardiovascular adverse effectsChronic heart failureHeart Failure TrialVentricular systolic dysfunctionΒ-blocker therapyRisk of hypotensionLife-saving therapyRandom-effects modelHF hospitalizationCause mortalitySystolic dysfunctionCause withdrawalsFailure TrialRandomized trialsAbsolute riskElectronic searchPatientsMEDLINE databaseTherapyAbsolute increase