2003
Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure
Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM. Association of Serum Digoxin Concentration and Outcomes in Patients With Heart Failure. JAMA 2003, 289: 871-878. PMID: 12588271, DOI: 10.1001/jama.289.7.871.Peer-Reviewed Original ResearchConceptsSerum digoxin concentrationHigh serum digoxin concentrationsLeft ventricular ejection fractionVentricular ejection fractionHeart failureMortality rateDIG trialDigoxin therapyEjection fractionDigoxin concentrationsDepressed left ventricular systolic functionDigitalis Investigation Group trialHigher absolute mortality rateLeft ventricular systolic functionOverall mortality benefitVentricular systolic functionCause mortality ratesAbsolute mortality ratesLower mortality rateCause mortalityMultivariable adjustmentMortality benefitSystolic functionClinical outcomesSerum concentrations
2002
Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure
Rathore SS, Wang Y, Krumholz HM. Sex-Based Differences in the Effect of Digoxin for the Treatment of Heart Failure. New England Journal Of Medicine 2002, 347: 1403-1411. PMID: 12409542, DOI: 10.1056/nejmoa021266.Peer-Reviewed Original ResearchConceptsEffect of digoxinDepressed left ventricular systolic functionLeft ventricular systolic functionVentricular systolic functionSex-based differencesRate of deathDigoxin therapyHeart failureSystolic functionMultivariable Cox proportional hazards modelsDigitalis Investigation Group (DIG) studyDigitalis Investigation Group trialCox proportional hazards modelHeart failure variesPrimary end pointRisk of deathProportional hazards modelMantel-Haenszel testOverall mortalityTherapy differsEpidemiologic featuresMultivariable analysisClinical variablesSubgroup analysisGroup trials