2020
Association Between Depressive Symptoms and Incident Cardiovascular Diseases
Harshfield EL, Pennells L, Schwartz JE, Willeit P, Kaptoge S, Bell S, Shaffer JA, Bolton T, Spackman S, Wassertheil-Smoller S, Kee F, Amouyel P, Shea SJ, Kuller LH, Kauhanen J, van Zutphen EM, Blazer DG, Krumholz H, Nietert PJ, Kromhout D, Laughlin G, Berkman L, Wallace RB, Simons LA, Dennison EM, Barr ELM, Meyer HE, Wood AM, Danesh J, Di Angelantonio E, Davidson KW. Association Between Depressive Symptoms and Incident Cardiovascular Diseases. JAMA 2020, 324: 2396-2405. PMID: 33320224, PMCID: PMC7739139, DOI: 10.1001/jama.2020.23068.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHazard ratioStroke eventsCardiovascular diseaseCorresponding incidence ratesDepressive symptomsHigher depression scoresCHD eventsCVD eventsCVD incidencePooled analysisIncidence rateDepression scoresNonfatal coronary heart diseasePatient Health Questionnaire-2Epidemiological Studies Depression ScaleIncident cardiovascular diseasePHQ-2 scoreAdditional risk factorsBaseline depressive symptomsSelf-reported depressive symptomsCES-D scoresEmerging Risk Factors CollaborationIndividual participant dataUK Biobank
2019
Interplay of Coronary Artery Calcium and Risk Factors for Predicting CVD/CHD Mortality The CAC Consortium
Grandhi GR, Mirbolouk M, Dardari ZA, Al-Mallah MH, Rumberger JA, Shaw LJ, Blankstein R, Miedema MD, Berman DS, Budoff MJ, Krumholz HM, Blaha MJ, Nasir K. Interplay of Coronary Artery Calcium and Risk Factors for Predicting CVD/CHD Mortality The CAC Consortium. JACC Cardiovascular Imaging 2019, 13: 1175-1186. PMID: 31734198, DOI: 10.1016/j.jcmg.2019.08.024.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedCause of DeathComputed Tomography AngiographyCoronary AngiographyCoronary Artery DiseaseDiabetes MellitusDyslipidemiasFemaleHeart Disease Risk FactorsHumansHypertensionMaleMiddle AgedMultidetector Computed TomographyPredictive Value of TestsPrevalencePrognosisRetrospective StudiesRisk AssessmentSmokingTime FactorsUnited StatesVascular CalcificationConceptsCoronary artery calciumCoronary heart diseaseRisk factorsCause-specific mortalityRF burdenCause mortalityArtery calciumCAC scoreCVD mortalityAbsence of CACHigher CAC scoresCHD mortality ratesCurrent cigarette smokingCardiovascular disease deathsCAC ConsortiumCAC testingMulticenter cohortCigarette smokingDisease deathsHeart diseasePrognostic informationBaseline riskFamily historyMost deathsMortality rateP573Effects of mobile text messaging on glycemic control in patients with coronary heart disease and diabetes mellitus: a randomized controlled trial
Huo X, Krumholz H, Bai X, Spatz E, Ding Q, Horak P, Zhao W, Gong Q, Yan X, Wu X, Li J, Li X, Spertus J, Masoudi F, Zheng X. P573Effects of mobile text messaging on glycemic control in patients with coronary heart disease and diabetes mellitus: a randomized controlled trial. European Heart Journal 2019, 40: ehz747.0184. DOI: 10.1093/eurheartj/ehz747.0184.Peer-Reviewed Original ResearchCoronary heart diseaseIntervention groupPhysical activityControl groupGlycemic controlHeart diseaseBaseline 6 monthsHigh-risk patientsText messaging programsSecondary outcome analysisMobile health interventionsText message programMean change differenceBP controlGlycemic hemoglobinHbA1c levelsLifestyle modificationUsual careDiabetes mellitusFamily Planning CommissionPrimary outcomeLifestyle recommendationsMonth followRisk factorsClinical trialsWorld Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions
Group T, Kaptoge S, Pennells L, De Bacquer D, Cooney M, Kavousi M, Stevens G, Riley L, Savin S, Khan T, Altay S, Amouyel P, Assmann G, Bell S, Ben-Shlomo Y, Berkman L, Beulens J, Björkelund C, Blaha M, Blazer D, Bolton T, Beaglehole R, Brenner H, Brunner E, Casiglia E, Chamnan P, Choi Y, Chowdry R, Coady S, Crespo C, Cushman M, Dagenais G, D'Agostino R, Daimon M, Davidson K, Engström G, Ford I, Gallacher J, Gansevoort R, Gaziano T, Giampaoli S, Grandits G, Grimsgaard S, Grobbee D, Gudnason V, Guo Q, Tolonen H, Humphries S, Iso H, Jukema J, Kauhanen J, Kengne A, Khalili D, Koenig W, Kromhout D, Krumholz H, Lam T, Laughlin G, Ibañez A, Meade T, Moons K, Nietert P, Ninomiya T, Nordestgaard B, O'Donnell C, Palmieri L, Patel A, Perel P, Price J, Providencia R, Ridker P, Rodriguez B, Rosengren A, Roussel R, Sakurai M, Salomaa V, Sato S, Schöttker B, Shara N, Shaw J, Shin H, Simons L, Sofianopoulou E, Sundström J, Völzke H, Wallace R, Wareham N, Willeit P, Wood D, Wood A, Zhao D, Woodward M, Danaei G, Roth G, Mendis S, Onuma O, Varghese C, Ezzati M, Graham I, Jackson R, Danesh J, Di Angelantonio E. World Health Organization cardiovascular disease risk charts: revised models to estimate risk in 21 global regions. The Lancet Global Health 2019, 7: e1332-e1345. PMID: 31488387, PMCID: PMC7025029, DOI: 10.1016/s2214-109x(19)30318-3.Peer-Reviewed Original ResearchConceptsRisk prediction modelSystolic blood pressureCardiovascular disease riskBritish Heart FoundationIndividual participant dataCardiovascular diseaseBlood pressureTotal cholesterolC-indexFatal coronary heart diseaseNon-fatal cardiovascular diseaseDisease riskCardiovascular disease risk predictionParticipant dataIncident cardiovascular eventsHistory of diabetesRisk factor profileRisk prediction chartsWHO STEPwise approachSex-specific incidenceUK Medical Research CouncilCoronary heart diseaseFirst myocardial infarctionExternal validation cohortHarrell's C-indexEffects of Mobile Text Messaging on Glycemic Control in Patients With Coronary Heart Disease and Diabetes Mellitus
Huo X, Krumholz HM, Bai X, Spatz ES, Ding Q, Horak P, Zhao W, Gong Q, Zhang H, Yan X, Sun Y, Liu J, Wu X, Guan W, Wang X, Li J, Li X, Spertus JA, Masoudi FA, Zheng X. Effects of Mobile Text Messaging on Glycemic Control in Patients With Coronary Heart Disease and Diabetes Mellitus. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005805. PMID: 31474119, DOI: 10.1161/circoutcomes.119.005805.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsian PeopleBiomarkersBlood GlucoseChinaCoronary DiseaseCulturally Competent CareDiabetes MellitusExerciseFemaleGlycated HemoglobinHealth CommunicationHealthy LifestyleHumansHypoglycemic AgentsMaleMedication AdherenceMiddle AgedMotivationPatient Education as TopicRisk Reduction BehaviorSelf CareSingle-Blind MethodTelemedicineText MessagingTime FactorsTreatment OutcomeConceptsCoronary heart diseaseHeart diseaseGlycemic controlIntervention groupUsual careDiabetes mellitusBlood glucosePhysical activityControl groupText message-based interventionBlood pressure controlProportion of patientsRisk factor managementGood glycemic controlSystolic blood pressureBody mass indexText messaging programsText message interventionMobile health interventionsSecondary outcomesBlood pressurePrimary outcomeLDL cholesterolMass indexMedication adherenceEffect of Text Messaging on Risk Factor Management in Patients With Coronary Heart Disease
Zheng X, Spatz ES, Bai X, Huo X, Ding Q, Horak P, Wu X, Guan W, Chow CK, Yan X, Sun Y, Wang X, Zhang H, Liu J, Li J, Li X, Spertus JA, Masoudi FA, Krumholz HM. Effect of Text Messaging on Risk Factor Management in Patients With Coronary Heart Disease. Circulation Cardiovascular Quality And Outcomes 2019, 12: e005616. PMID: 30998400, DOI: 10.1161/circoutcomes.119.005616.Peer-Reviewed Original ResearchMeSH KeywordsAgedAsian PeopleBlood PressureChinaCoronary DiseaseCulturally Competent CareFemaleHealth Knowledge, Attitudes, PracticeHumansMaleMiddle AgedPatient Education as TopicRisk AssessmentRisk FactorsSecondary PreventionSingle-Blind MethodTelemedicineText MessagingTime FactorsTreatment OutcomeConceptsCoronary heart diseaseSystolic blood pressureBody mass indexBlood pressureHeart diseaseSecondary preventionIntervention groupPhysical activityEnd pointSmoking statusMass indexControl groupPrimary end pointRisk factor controlSecondary end pointsRisk factor managementLDL-C levelsDisease-specific knowledgeMobile phone textMobile health technologyUsual careDiabetes mellitusMedication adherenceRisk factorsFactor management
2018
Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction
Wang Y, Li J, Zheng X, Jiang Z, Hu S, Wadhera RK, Bai X, Lu J, Wang Q, Li Y, Wu C, Xing C, Normand SL, Krumholz HM, Jiang L. Risk Factors Associated With Major Cardiovascular Events 1 Year After Acute Myocardial Infarction. JAMA Network Open 2018, 1: e181079-e181079. PMID: 30646102, PMCID: PMC6324290, DOI: 10.1001/jamanetworkopen.2018.1079.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMajor cardiovascular eventsCardiovascular eventsRisk factorsC-statisticMyocardial infarctionAggressive risk factor reductionOne-year event ratesSubsequent major cardiovascular eventsRecurrent acute myocardial infarctionIndex AMI hospitalizationRisk factor reductionHigh-risk patientsProspective cohort studyCoronary heart diseaseLow-risk groupAcute care hospitalsCohort studyCommon comorbiditiesHeart failureMean ageRisk modelHeart diseaseMAIN OUTCOMEHigh risk
2017
Design and rationale of the Cardiovascular Health and Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study: two randomised controlled trials of text messaging to improve secondary prevention for coronary heart disease and diabetes
Huo X, Spatz ES, Ding Q, Horak P, Zheng X, Masters C, Zhang H, Irwin ML, Yan X, Guan W, Li J, Li X, Spertus JA, Masoudi FA, Krumholz HM, Jiang L. Design and rationale of the Cardiovascular Health and Text Messaging (CHAT) Study and the CHAT-Diabetes Mellitus (CHAT-DM) Study: two randomised controlled trials of text messaging to improve secondary prevention for coronary heart disease and diabetes. BMJ Open 2017, 7: e018302. PMID: 29273661, PMCID: PMC5778311, DOI: 10.1136/bmjopen-2017-018302.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedAged, 80 and overBlood PressureChinaCoronary DiseaseDiabetes Mellitus, Type 1Diabetes Mellitus, Type 2ExerciseFemaleGlycated HemoglobinHumansLife StyleMaleMedication AdherenceMiddle AgedMotivationResearch DesignRisk FactorsSecondary PreventionSelf CareSingle-Blind MethodTelemedicineText MessagingYoung AdultConceptsSystolic blood pressureBody mass indexTrials of textProportion of patientsMedication adherencePhysical activitySecondary outcomesPrimary outcomeSmoking cessationCardiovascular healthMellitus StudySecondary coronary heart disease preventionCoronary heart disease preventionLow-density lipoprotein cholesterolUsual scientific forumsBlood pressure controlRisk factor managementHeart disease preventionCoronary heart diseaseMobile health interventionsInstitutional review boardUniversity Institutional Review BoardBehavioral skills modelText messagingBehavioral change techniques
2016
Acute Myocardial Infarction in Women
Mehta LS, Beckie TM, DeVon HA, Grines CL, Krumholz HM, Johnson MN, Lindley KJ, Vaccarino V, Wang TY, Watson KE, Wenger NK. Acute Myocardial Infarction in Women. Circulation 2016, 133: 916-947. PMID: 26811316, DOI: 10.1161/cir.0000000000000351.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionMortality rateFirst scientific statementOutcomes of womenCardiovascular disease mortalityCardiovascular disease riskCardiovascular disease mortality ratesCoronary heart diseaseAmerican Heart AssociationDisease mortality ratesEvidence-based treatmentsCause of mortalityClinical presentationPathophysiological mechanismsHeart AssociationDisease mortalityHeart diseaseCardiovascular diseaseSex-specific differencesCurrent evidenceInfarctionDisease riskWomenScientific statement
2008
Prevention of Heart Failure
Schocken DD, Benjamin EJ, Fonarow GC, Krumholz HM, Levy D, Mensah GA, Narula J, Shor ES, Young JB, Hong Y. Prevention of Heart Failure. Circulation 2008, 117: 2544-2565. PMID: 18391114, DOI: 10.1161/circulationaha.107.188965.Peer-Reviewed Original ResearchConceptsPrevention of HFChronic kidney diseaseCoronary heart diseaseKidney diseaseHeart diseaseRisk factorsAsymptomatic left ventricular systolic dysfunctionLeft ventricular systolic dysfunctionLeft ventricular systolic functionHF prevention strategiesVentricular systolic dysfunctionVentricular systolic functionHeart failure ratesDevelopment of HFNational awareness campaignGenetic risk factorsEvidence-based managementSystolic dysfunctionSystolic functionHeart failurePatient groupPathophysiological basisPrevention strategiesDiseaseEarly detection
2002
Spectrum of heart failure in older patients: Results from the national heart failure project
Havranek EP, Masoudi FA, Westfall KA, Wolfe P, Ordin DL, Krumholz HM. Spectrum of heart failure in older patients: Results from the national heart failure project. American Heart Journal 2002, 143: 412-417. PMID: 11868045, DOI: 10.1067/mhj.2002.120773.Peer-Reviewed Original ResearchConceptsLong-term care facilitiesHeart failureCare facilitiesElderly patientsClinical trialsNational Heart Failure ProjectLeft ventricular ejection fractionLeft ventricular systolic functionChronic obstructive pulmonary diseaseAssociated laboratory abnormalitiesHeart Failure ProjectHistory of hypertensionPoor renal functionThird of patientsVentricular systolic functionMajority of patientsMultiple comorbid conditionsObstructive pulmonary diseaseVentricular ejection fractionExclusion of patientsLong-term hemodialysisCoronary heart diseasePopulation-based studyAcute care facilitiesEvidence-based guidanceDepression and Risk of Heart Failure Among the Elderly: A Prospective Community-Based Study
Williams SA, Kasl SV, Heiat A, Abramson JL, Krumholz HM, Vaccarino V. Depression and Risk of Heart Failure Among the Elderly: A Prospective Community-Based Study. Psychosomatic Medicine 2002, 64: 6-12. PMID: 11818580, DOI: 10.1097/00006842-200201000-00002.Peer-Reviewed Original ResearchConceptsHeart failureIndependent risk factorCoronary heart diseaseImpact of depressionEffect of depressionHospital admissionComorbidity factorsCox regressionProspective CommunityElderly menFunctional statusHeart diseaseRisk factorsElderly womenBaseline differencesEpidemiological studiesFunctional limitationsGreater riskUnderlying causeDepressionIncidenceEstablished PopulationsCommunity sampleDepressed participantsWomen
2001
Pulse pressure and risk of cardiovascular events in the systolic hypertension in the elderly program
Vaccarino V, Berger A, Abramson J, Black H, Setaro J, Davey J, Krumholz H. Pulse pressure and risk of cardiovascular events in the systolic hypertension in the elderly program. The American Journal Of Cardiology 2001, 88: 980-986. PMID: 11703993, DOI: 10.1016/s0002-9149(01)01974-9.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseRisk of HFSystolic hypertensionRisk of strokeHeart failurePulse pressureCardiovascular eventsBlood pressureElderly ProgramRisk factorsTreatment groupsIncidence of CHDPlacebo-controlled clinical trialOlder adultsIsolated systolic hypertensionDiastolic blood pressureSystolic blood pressureElevated pulse pressureInfluence of treatmentCardiovascular outcomesPlacebo groupSystolic pressureDiastolic pressureHeart diseaseClinical trialsDepression and Risk of Heart Failure Among Older Persons With Isolated Systolic Hypertension
Abramson J, Berger A, Krumholz HM, Vaccarino V. Depression and Risk of Heart Failure Among Older Persons With Isolated Systolic Hypertension. JAMA Internal Medicine 2001, 161: 1725-1730. PMID: 11485505, DOI: 10.1001/archinte.161.14.1725.Peer-Reviewed Original ResearchConceptsHeart failureSystolic hypertensionMyocardial infarctionDepressed personsOlder personsCox proportional hazards regressionEpidemiological Studies Depression ScaleIsolated systolic hypertensionIncident heart failureCoronary heart diseaseProportional hazards regressionBlood pressureElectrocardiographic abnormalitiesHazards regressionElderly ProgramCholesterol levelsHeart diseaseRisk factorsNondepressed personsDepression ScaleAdditional adjustmentElevated riskHigh riskTreatment groupsHypertensionDepressive symptoms and risk of functional decline and death in patients with heart failure
Vaccarino V, Kasl S, Abramson J, Krumholz H. Depressive symptoms and risk of functional decline and death in patients with heart failure. Journal Of The American College Of Cardiology 2001, 38: 199-205. PMID: 11451275, DOI: 10.1016/s0735-1097(01)01334-1.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseHeart failureDepressive symptomsFunctional declineCombined end pointDecompensated heart failureBaseline functional statusNegative prognostic factorGeriatric Depression ScaleYears of ageIntermediate riskHospital admissionPrognostic factorsPoor outcomePoor prognosisFunctional statusMedical historyHeart diseaseRisk factorsClinical severityDepression ScaleDaily livingHigh riskPatientsMultivariate analysis
2000
Pulse pressure and risk for myocardial infarction and heart failure in the elderly
Vaccarino V, Holford T, Krumholz H. Pulse pressure and risk for myocardial infarction and heart failure in the elderly. Journal Of The American College Of Cardiology 2000, 36: 130-138. PMID: 10898424, DOI: 10.1016/s0735-1097(00)00687-2.Peer-Reviewed Original ResearchConceptsCongestive heart failureCoronary heart diseaseSystolic blood pressureCardiovascular end pointsDiastolic blood pressurePulse pressureBlood pressureEnd pointHeart failureIndependent predictorsOverall mortalityIncidence of CHFIncidence of CHDEffect of PPElevated systolic blood pressureCurrent hypertension guidelinesIncident CHF eventsCHD risk factorsCurrent medication useIncident CHD eventsPowerful independent predictorBlood pressure parametersBlood pressure variablesElevated pulse pressureDiastolic hypertension
1999
Sex differences in the clinical care and outcomes of congestive heart failure in the elderly
Vaccarino V, Chen Y, Wang Y, Radford M, Krumholz H. Sex differences in the clinical care and outcomes of congestive heart failure in the elderly. American Heart Journal 1999, 138: 835-842. PMID: 10539813, DOI: 10.1016/s0002-8703(99)70007-4.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAngiotensin-Converting Enzyme InhibitorsAspirinBlood PressureCardiac CatheterizationConnecticutCoronary AngiographyDiureticsDrug Therapy, CombinationFemaleFollow-Up StudiesHeart FailureHumansMaleMyocardial RevascularizationPatient ReadmissionPlatelet Aggregation InhibitorsRetrospective StudiesSeverity of Illness IndexSex CharacteristicsStroke VolumeSurvival RateTreatment OutcomeConceptsHistory of hypertensionSystolic blood pressureHeart failureMortality rateBlood pressureHeart diseaseHigher systolic blood pressureLeft ventricular systolic functionSex differencesPrevious coronary heart diseaseSimilar hospital coursesVentricular systolic functionCongestive heart failureIschemic heart diseaseCoronary heart diseaseHospital courseElderly patientsReadmission ratesRehospitalization ratesSystolic functionMale patientsVentricular functionACE inhibitorsMultivariable analysisTreatment patternsGender differences in symptom presentation associated with coronary heart disease
Milner K, Funk M, Richards S, Wilmes R, Vaccarino V, Krumholz H. Gender differences in symptom presentation associated with coronary heart disease. The American Journal Of Cardiology 1999, 84: 396-399. PMID: 10468075, DOI: 10.1016/s0002-9149(99)00322-7.Peer-Reviewed Original ResearchConceptsCoronary heart diseaseNon-chest pain symptomsChest painEmergency departmentPain symptomsUnadjusted analysesHeart diseaseSymptom presentationYale-New Haven HospitalSubgroup of patientsNurse data collectorsGender differencesMidback painProspective studyPainNauseaVomitingSymptomsPatientsWomenDyspneaSignificant gender differencesMenDiseaseIndigestionCost-Effectiveness Analysis and the Treatment of Acute Coronary Syndromes
Krumholz H. Cost-Effectiveness Analysis and the Treatment of Acute Coronary Syndromes. Contemporary Cardiology 1999, 601-610. DOI: 10.1007/978-1-59259-731-4_25.Peer-Reviewed Original ResearchAcute coronary syndromeCoronary heart diseaseHealth care resourcesCost-effectiveness analysisHealth care systemHealth care expendituresCoronary syndromeCardiac eventsPharmacologic interventionsHeart diseaseEfficacious therapyCardiovascular diseaseCare resourcesNew interventionsCare expendituresCare systemHealth benefitsInterventionCare organizationsDiseaseTreatmentStandard practicePatientsHospitalSyndrome
1998
Depression and Risk of Coronary Heart Disease in Elderly Men and Women: New Haven EPESE, 1982-1991
Mendes de Leon CF, Krumholz HM, Seeman TS, Vaccarino V, Williams CS, Kasl SV, Berkman LF. Depression and Risk of Coronary Heart Disease in Elderly Men and Women: New Haven EPESE, 1982-1991. JAMA Internal Medicine 1998, 158: 2341-2348. PMID: 9827785, DOI: 10.1001/archinte.158.21.2341.Peer-Reviewed Original ResearchMeSH KeywordsActivities of Daily LivingAge FactorsAgedCause of DeathCohort StudiesConnecticutCoronary DiseaseDeath CertificatesDepressionFemaleForecastingHospitalizationHumansIncidenceInterviews as TopicMaleMedical AuditMyocardial InfarctionOutcome Assessment, Health CarePatient AdmissionReproducibility of ResultsRisk FactorsSex FactorsSurvival RateConceptsCoronary heart diseaseCHD risk factorsDepressive symptomsRisk factorsCHD outcomesHeart diseaseAge-adjusted relative riskImpaired physical functionIncident coronary diseasePhysical function impairmentIncident CHD eventsNonfatal myocardial infarctionIndependent risk factorMedical chart reviewHealthy older womenCause of deathCHD deathCHD eventsCHD mortalityChart reviewCHD incidenceCoronary diseaseFunction impairmentPhysical functionElderly men