2020
Associations Between the Severity of Influenza Seasons and Mortality and Readmission Risks After Elective Surgical Aortic Valve Replacement and Coronary Artery Bypass Graft Surgery in Older Adults
Mori M, Wang Y, Mahajan S, Geirsson A, Krumholz HM. Associations Between the Severity of Influenza Seasons and Mortality and Readmission Risks After Elective Surgical Aortic Valve Replacement and Coronary Artery Bypass Graft Surgery in Older Adults. JAMA Network Open 2020, 3: e2031078. PMID: 33355673, PMCID: PMC7758803, DOI: 10.1001/jamanetworkopen.2020.31078.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementElective surgical aortic valve replacementAortic valve replacementValve replacementReadmission riskCoronary artery bypass graft surgeryArtery bypass graft surgeryOlder adultsBypass graft surgeryCoronary artery bypassCross-sectional studyArtery bypassGraft surgeryInfluenza seasonMedicaid ServicesMortalitySeverityAdultsRiskAssociationSurgeryBypass
2019
Comparison of Machine Learning Methods With National Cardiovascular Data Registry Models for Prediction of Risk of Bleeding After Percutaneous Coronary Intervention
Mortazavi BJ, Bucholz EM, Desai NR, Huang C, Curtis JP, Masoudi FA, Shaw RE, Negahban SN, Krumholz HM. Comparison of Machine Learning Methods With National Cardiovascular Data Registry Models for Prediction of Risk of Bleeding After Percutaneous Coronary Intervention. JAMA Network Open 2019, 2: e196835. PMID: 31290991, PMCID: PMC6624806, DOI: 10.1001/jamanetworkopen.2019.6835.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionMajor bleedingC-statisticCoronary interventionMAIN OUTCOMEIndex percutaneous coronary interventionSubsequent coronary artery bypassPercutaneous coronary intervention (PCI) proceduresHospital major bleedingMajor bleeding ratesNationwide clinical registryCoronary artery bypassCoronary intervention proceduresComparative effectiveness studiesRisk score modelComplexity of presentationMean c-statisticCoronary angiography dataRegistry modelNCDR modelsArtery bypassBleeding eventsPrediction of riskClinical variablesBleeding rate
2018
Sex and Race Differences in the Utilization and Outcomes of Coronary Artery Bypass Grafting Among Medicare Beneficiaries, 1999–2014
Angraal S, Khera R, Wang Y, Lu Y, Jean R, Dreyer RP, Geirsson A, Desai NR, Krumholz HM. Sex and Race Differences in the Utilization and Outcomes of Coronary Artery Bypass Grafting Among Medicare Beneficiaries, 1999–2014. Journal Of The American Heart Association 2018, 7: e009014. PMID: 30005557, PMCID: PMC6064835, DOI: 10.1161/jaha.118.009014.Peer-Reviewed Original ResearchConceptsCoronary artery bypassCABG utilizationArtery bypassUse of CABGService Medicare beneficiariesCalendar year trendsCABG mortalityUnderwent CABGReadmission ratesCABG proceduresWhite patientsBlack patientsPatient groupMedicare beneficiariesMedicare feeMortality rateCABGAnnual declineWomenRacial subgroupsRacial differencesGreater declineOutcomesPatientsSex
2017
Trends in mortality and major complications for patients undergoing coronary artery bypass grafting among Urban Teaching Hospitals in China: 2004 to 2013
Yuan X, Zhang H, Zheng Z, Rao C, Zhao Y, Wang Y, Krumholz HM, Hu S. Trends in mortality and major complications for patients undergoing coronary artery bypass grafting among Urban Teaching Hospitals in China: 2004 to 2013. European Heart Journal - Quality Of Care And Clinical Outcomes 2017, 3: 312-318. PMID: 29044398, PMCID: PMC5805118, DOI: 10.1093/ehjqcco/qcx021.Peer-Reviewed Original ResearchConceptsMajor complication rateUrban teaching hospitalCoronary artery bypassComplication rateHospital mortalityTeaching hospitalArtery bypassMean ageChinese Cardiac Surgery RegistryAge groupsAnnual CABG volumePost-operative LOSPatients' mean ageCardiac Surgery RegistryPatient characteristicsCardiac surgeryMajor complicationsNumber of hospitalsCABG volumeTotal LOSHospitalMortalityPatientsRegistry systemMixed effects modelsComparing Outcomes of Coronary Artery Bypass Grafting Among Large Teaching and Urban Hospitals in China and the United States
Zheng Z, Zhang H, Yuan X, Rao C, Zhao Y, Wang Y, Normand SL, Krumholz HM, Hu S. Comparing Outcomes of Coronary Artery Bypass Grafting Among Large Teaching and Urban Hospitals in China and the United States. Circulation Cardiovascular Quality And Outcomes 2017, 10: e003327. PMID: 28611187, PMCID: PMC5482563, DOI: 10.1161/circoutcomes.116.003327.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultAgedChinaCoronary Artery BypassCoronary Artery DiseaseFemaleHealthcare DisparitiesHospital Bed CapacityHospital MortalityHospitals, High-VolumeHospitals, TeachingHospitals, UrbanHumansLength of StayMaleMiddle AgedOdds RatioPrevalenceProcess Assessment, Health CarePropensity ScoreQuality Indicators, Health CareRegistriesRisk AssessmentRisk FactorsTime FactorsTreatment OutcomeUnited StatesYoung AdultConceptsIsolated CABG surgeryCoronary artery bypassUrban hospitalHospital mortalityArtery bypassCABG surgeryChinese Cardiac Surgery RegistryTotal hospital stayCardiac Surgery RegistryCoronary artery diseaseNational Inpatient SampleLarge teachingLength of staySignificant mortality differenceHospital staySecondary outcomesArtery diseasePrimary outcomeMedian lengthComparing outcomesInpatient SampleMortality differencesHigher ageHigh mortalityHospital
2016
Hospital Phenotypes in the Management of Patients Admitted for Acute Myocardial Infarction
Xu X, Li SX, Lin H, Normand SL, Lagu T, Desai N, Duan M, Kroch EA, Krumholz HM. Hospital Phenotypes in the Management of Patients Admitted for Acute Myocardial Infarction. Medical Care 2016, 54: 929-936. PMID: 27261637, PMCID: PMC5305177, DOI: 10.1097/mlr.0000000000000571.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPercutaneous coronary interventionICU admission rateICU admissionMyocardial infarctionAdmission ratesProcedure ratesIntensive care unit admissionHigher ICU admissionLower ICU admissionCare unit admissionCoronary artery bypassPatients' clinical characteristicsManagement of patientsOpen heart surgeryRisk-standardized mortalityArtery bypassUnit admissionClinical characteristicsCoronary interventionReadmission ratesGroup of hospitalsHospital costsPractice patternsCABG
2013
Determinants of fluoroscopy time for invasive coronary angiography and percutaneous coronary intervention: Insights from the NCDR®
Fazel R, Curtis J, Wang Y, Einstein AJ, Smith‐Bindman R, Tsai TT, Chen J, Shah ND, Krumholz HM, Nallamothu BK. Determinants of fluoroscopy time for invasive coronary angiography and percutaneous coronary intervention: Insights from the NCDR®. Catheterization And Cardiovascular Interventions 2013, 82: 1091-1105. PMID: 23703793, DOI: 10.1002/ccd.24996.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionInvasive coronary angiographyHospital-level factorsFluoroscopy timePrior CABGCoronary interventionPrior coronary artery bypassRadiation exposureCoronary artery bypassNumerous clinical scenariosArtery bypassCathPCI RegistryPatient characteristicsCoronary angiographyPCI proceduresModifiable determinantsPatientsClinical scenariosModifiable sourceProcedure complexityCABGMinutesInterventionExposureWide variation
2012
Coronary Artery Bypass Graft
Hu S, Zheng Z, Yuan X, Wang Y, Normand SL, Ross JS, Krumholz HM. Coronary Artery Bypass Graft. Circulation Cardiovascular Quality And Outcomes 2012, 5: 214-221. PMID: 22396587, PMCID: PMC3509783, DOI: 10.1161/circoutcomes.111.962365.Peer-Reviewed Original ResearchConceptsChinese Cardiac Surgery RegistryCardiac Surgery RegistryCABG surgeryComplication rateCoronary artery bypass graftCoronary artery bypassMajor complication rateArtery bypass graftCause mortality ratesNational multicenter databaseHospital-level performanceArtery bypassHospital mortalityMediastinal infectionRenal failureConsecutive patientsBypass graftMulticenter databaseMean ageMyocardial infarctionNational registryCABG facilitiesMortality rateSurgeryHospital
2010
Thirty-Day Outcomes in Medicare Patients With Heart Failure at Heart Transplant Centers
Hummel SL, Pauli NP, Krumholz HM, Wang Y, Chen J, Normand SL, Nallamothu BK. Thirty-Day Outcomes in Medicare Patients With Heart Failure at Heart Transplant Centers. Circulation Heart Failure 2010, 3: 244-252. PMID: 20061519, DOI: 10.1161/circheartfailure.109.884098.Peer-Reviewed Original ResearchConceptsHeart transplant centersRisk-standardized readmission ratesRisk-standardized mortality ratesTransplant centersStandardized mortality ratioHeart failureTransplant hospitalsReadmission ratesMortality rateStandardized readmission ratioMortality ratioMedicare patientsReadmission ratiosMean standardized mortality ratioThirty-day outcomesCoronary artery bypassHeart failure careElderly Medicare patientsElderly Medicare beneficiariesArtery bypassElderly patientsTransplant candidatesMedicare beneficiariesHospitalPatients
2007
Temporal Trends of Outcomes for Nonagenarians Undergoing Coronary Artery Bypass Grafting, 1993 to 1999
Lichtman JH, Kapoor R, Wang Y, Radford MJ, Allen NB, Krumholz HM. Temporal Trends of Outcomes for Nonagenarians Undergoing Coronary Artery Bypass Grafting, 1993 to 1999. The American Journal Of Cardiology 2007, 100: 1630-1634. PMID: 18036360, DOI: 10.1016/j.amjcard.2007.06.067.Peer-Reviewed Original ResearchConceptsCABG proceduresMortality outcomesMortality rateLong-term mortality outcomesShort-term mortality outcomesOverall crude mortality rateService Medicare patientsCoronary artery bypassLength of stayCrude mortality rateService Medicare beneficiariesSkilled nursing facilitiesHigh mortality rateProjected life expectancyNumber of proceduresArtery bypassDischarge dispositionMedicare patientsMedicare beneficiariesNursing facilitiesNonagenariansMean lengthTemporal trendsLife expectancyWomen
2006
Impact of Chronic Kidney Disease on Health-Related Quality-of-Life Improvement After Coronary Artery Bypass Surgery
Parikh CR, Coca SG, Smith GL, Vaccarino V, Krumholz HM. Impact of Chronic Kidney Disease on Health-Related Quality-of-Life Improvement After Coronary Artery Bypass Surgery. JAMA Internal Medicine 2006, 166: 2014-2019. PMID: 17030836, DOI: 10.1001/archinte.166.18.2014.Peer-Reviewed Original ResearchConceptsSevere chronic kidney diseaseChronic kidney diseasePhysical functionMH scorePF scoresKidney diseaseMedical Outcomes Trust Short FormAdvanced chronic kidney diseaseCoronary artery bypass surgeryLife outcomesCoronary artery bypassPrimary end pointArtery bypass surgeryHealth-related qualityCoronary artery diseaseMH subscalesArtery bypassCKD stageBypass surgeryArtery diseaseHealth SurveyMean changeStage 0Mean decreaseCABGPerceived control and change in physical functioning after coronary artery bypass grafting: A prospective study
Barry LC, Kasl SV, Lichtman J, Vaccarino V, Krumholz HM. Perceived control and change in physical functioning after coronary artery bypass grafting: A prospective study. International Journal Of Behavioral Medicine 2006, 13: 229-236. PMID: 17078773, DOI: 10.1207/s15327558ijbm1303_6.Peer-Reviewed Original ResearchConceptsHealth-related controlCoronary artery bypassPhysical functioningArtery bypassHospital dischargeIndependent predictorsProspective studyCaucasian manMean ageSignificant associationOne-way analysisMeasure outcomesBypassIntervention effortsMonthsWeeksX timeSignificant interactionBeneficial impactPositive changesPatientsComparison of Functional Status After Coronary Artery Bypass Grafting in Patients With and Without Diabetes Mellitus
Sahakyan K, Abramson JL, Krumholz HM, Vaccarino V. Comparison of Functional Status After Coronary Artery Bypass Grafting in Patients With and Without Diabetes Mellitus. The American Journal Of Cardiology 2006, 98: 619-623. PMID: 16923448, DOI: 10.1016/j.amjcard.2006.03.038.Peer-Reviewed Original ResearchConceptsPhysical Component Scale scoresCoronary artery bypassDiabetes mellitusPhysical functionMental healthArtery bypassScale scoreRisk of morbidityMental component scaleShort formHealth Survey dataDM statusFirst CABGCABG surgeryBaseline characteristicsConsecutive patientsFunctional recoveryFunctional statusPhysical functioningHealth SurveyCABGPatientsScore changeMellitusComponent scalePrevalence and Predictors of Angina Pectoris One Month After Myocardial Infarction
Spertus JA, Dawson J, Masoudi FA, Krumholz HM, Reid KJ, Peterson ED, Rumsfeld JS, Consortium C. Prevalence and Predictors of Angina Pectoris One Month After Myocardial Infarction. The American Journal Of Cardiology 2006, 98: 282-288. PMID: 16860010, DOI: 10.1016/j.amjcard.2006.01.099.Peer-Reviewed Original ResearchConceptsAngina pectorisMyocardial infarctionCoronary artery bypass surgeryPrevious coronary artery bypassMultivariable logistic regression analysisPatient's myocardial infarctionCoronary artery bypassSeattle Angina QuestionnaireArtery bypass surgeryLogistic regression analysisQuality of lifeIndex admissionAngina QuestionnaireArtery bypassIndex hospitalizationBypass surgeryYounger patientsTreatable symptomsTreatment characteristicsPatientsOne monthAdditional treatmentMonthsInfarctionRegression analysisSocial support and change in health-related quality of life 6 months after coronary artery bypass grafting
Barry LC, Kasl SV, Lichtman J, Vaccarino V, Krumholz HM. Social support and change in health-related quality of life 6 months after coronary artery bypass grafting. Journal Of Psychosomatic Research 2006, 60: 185-193. PMID: 16439272, DOI: 10.1016/j.jpsychores.2005.06.080.Peer-Reviewed Original ResearchConceptsHealth-related qualityCoronary artery bypassPhysical functioningMental healthArtery bypassSF-36 subscale scoresAge 65.7 yearsLife 6 monthsStepwise linear regression analysisSocial supportFirst CABGHospital dischargeProspective cohortClinical presentationLinear regression analysisInstrumental supportChange scoresSubscale scoresMonthsSocial support variablesRegression analysisBypassHealthIntervention effortsEmotional support
2003
Patterns of Secondary Prevention in Older Patients Undergoing Coronary Artery Bypass Grafting During Hospitalization for Acute Myocardial Infarction
Foody JM, Ferdinand FD, Galusha D, Rathore SS, Masoudi FA, Havranek EP, Nilasena D, Radford MJ, Krumholz HM. Patterns of Secondary Prevention in Older Patients Undergoing Coronary Artery Bypass Grafting During Hospitalization for Acute Myocardial Infarction. Circulation 2003, 108: 24ii--28. PMID: 12970203, DOI: 10.1161/01.cir.0000087654.26917.00.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCoronary artery bypassOlder patientsArtery bypassSecondary preventionMyocardial infarctionAggressive risk factor modificationUtilization of therapyRisk factor modificationLong-term mortalityYears of ageCABG patientsDischarge aspirinDischarge therapyEligible patientsCardiovascular eventsSurgical mortalityLipid loweringACE inhibitorsFactor modificationMedical recordsCABGPatientsEnzyme inhibitorsDisease severity