2022
17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury
Kim AS, Werlin EC, Kagaya H, Chen M, Wu B, Mottola G, Jan M, Conte MS. 17R/S-Benzo-RvD1, a synthetic resolvin D1 analogue, attenuates neointimal hyperplasia in a rat model of acute vascular injury. PLOS ONE 2022, 17: e0264217. PMID: 35226675, PMCID: PMC8884511, DOI: 10.1371/journal.pone.0264217.Peer-Reviewed Original ResearchConceptsSpecialized lipid mediatorsNeointimal hyperplasiaVascular injuryRAW 264.7 cellsEndothelial cellsCarotid angioplastyPhagocytic activityAcute arterial injuryPro-resolving activitiesAcute vascular injuryCytokine-stimulated endothelial cellsP65 nuclear translocationAnti-migratory activityMurine RAW 264.7 cellsArterial injuryPersistent inflammationResolvin D1Ki67 expressionNeointimal areaSimilar efficacyLeukocyte recruitmentRat modelKi-67Lipid mediatorsNuclear translocation assays
2017
Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications
Wu B, Mottola G, Schaller M, Upchurch GR, Conte MS. Resolution of vascular injury: Specialized lipid mediators and their evolving therapeutic implications. Molecular Aspects Of Medicine 2017, 58: 72-82. PMID: 28765077, PMCID: PMC5660644, DOI: 10.1016/j.mam.2017.07.005.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsSpecialized pro-resolving lipid mediatorsVascular injuryLipid mediatorsVSMC migrationPro-resolving lipid mediatorsVascular smooth muscle cell activationSmooth muscle cell activationSpecialized lipid mediatorsAcute vascular injuryElaboration of cytokinesDisease-related eventsEndothelial cell disruptionMuscle cell activationImportant clinical contextsClearance of debrisMatrix protein depositionLeukocyte effluxBypass GraftingBypass surgeryBalloon angioplastyLeukocyte recruitmentAneurysm formationInflammatory signalsExperimental aneurysm formationLumen compromise