2004
Phase II Trial of Bortezomib for Patients With Advanced Renal Cell Carcinoma
Kondagunta GV, Drucker B, Schwartz L, Bacik J, Marion S, Russo P, Mazumdar M, Motzer RJ. Phase II Trial of Bortezomib for Patients With Advanced Renal Cell Carcinoma. Journal Of Clinical Oncology 2004, 22: 3720-3725. PMID: 15365068, DOI: 10.1200/jco.2004.10.155.Peer-Reviewed Original ResearchConceptsMetastatic renal cell carcinomaRenal cell carcinomaGrade 3 sensory neuropathyPartial responseSensory neuropathyCell carcinomaM2 groupAdvanced renal cell carcinomaToxicity of bortezomibPhase II trialAssessable patientsStable diseaseII trialInterferon alfaUnacceptable toxicityClinical responseCytokine therapyCombination therapyIntravenous administrationNovel agentsIndividual patientsDose reductionResponse durationHigh doseAntitumor effects
2002
Prognostic factors for biologic therapy in kidney cancer
Drucker BJ. Prognostic factors for biologic therapy in kidney cancer. Current Urology Reports 2002, 3: 31-36. PMID: 12084217, DOI: 10.1007/s11934-002-0008-5.Peer-Reviewed Original ResearchConceptsPrior nephrectomyCytokine therapyPrognostic factorsGood performance statusNormal lactate dehydrogenaseMajority of patientsLevels of cytokinesPresence of eosinophilsRenal cell cancerSubpopulations of lymphocytesLack of anemiaBiologic therapyPerformance statusImproved survivalCell cancerDisease characteristicsTumor responseNormal calciumImmune parametersInterleukin-2Kidney cancerTherapeutic benefitResponse rateTherapyLactate dehydrogenase