2015
Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor–Binding Protein-3 in Critical Illness*
Ahasic AM, Tejera P, Wei Y, Su L, Mantzoros CS, Bajwa EK, Thompson BT, Christiani DC. Predictors of Circulating Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor–Binding Protein-3 in Critical Illness*. Critical Care Medicine 2015, 43: 2651-2659. PMID: 26427594, PMCID: PMC4651824, DOI: 10.1097/ccm.0000000000001314.Peer-Reviewed Original ResearchMeSH KeywordsAcademic Medical CentersAcute DiseaseAge FactorsAgedAged, 80 and overAPACHEBody Mass IndexChronic DiseaseCritical IllnessFemaleGenotypeHumansInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor IIntensive Care UnitsLinear ModelsMaleMiddle AgedPhenotypePolymorphism, GeneticProspective StudiesRisk FactorsSex FactorsConceptsInsulin-like growth factor-binding protein-3Insulin-like growth factor-1Acute respiratory distress syndromeGrowth factor-1Respiratory distress syndromeInsulin-like growth factor-binding protein-3 levelsProtein-3 levelsCritical illnessBody mass indexDistress syndromeProtein 3Acute PhysiologyMass indexFactor 1Chronic Health Evaluation III scoreInsulin-like growth factor-1 levelsChronic Health Evaluation IIISepsis/septic shockGrowth factor-1 levelsTotal insulin-like growth factor-1Insulin-like growth factorAcute critical illnessAcute hepatic dysfunctionReceipt of corticosteroidsLarge prospective studies
2014
Adiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and Mortality
Ahasic AM, Zhao Y, Su L, Sheu CC, Thompson BT, Christiani DC. Adiponectin Gene Polymorphisms and Acute Respiratory Distress Syndrome Susceptibility and Mortality. PLOS ONE 2014, 9: e89170. PMID: 24586568, PMCID: PMC3929660, DOI: 10.1371/journal.pone.0089170.Peer-Reviewed Original ResearchConceptsARDS casesInsulin resistanceSingle nucleotide polymorphismsCase statusAcute respiratory distress syndrome (ARDS) riskFunctional polymorphismsAnti-inflammatory adipokineAcute respiratory failureDevelopment of ARDSAdiponectin gene polymorphismsMultiple comparisonsAdipokine levelsCause mortalityRespiratory failureAdiponectin levelsCritical illnessConsecutive patientsMultivariable analysisRisk factorsSyndrome riskCardiovascular diseaseAdipose tissueGene polymorphismsARDSMortalityMKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury
Mannam P, Shinn AS, Srivastava A, Neamu RF, Walker WE, Bohanon M, Merkel J, Kang MJ, Dela Cruz CS, Ahasic AM, Pisani MA, Trentalange M, West AP, Shadel GS, Elias JA, Lee PJ. MKK3 regulates mitochondrial biogenesis and mitophagy in sepsis-induced lung injury. American Journal Of Physiology - Lung Cellular And Molecular Physiology 2014, 306: l604-l619. PMID: 24487387, PMCID: PMC3962628, DOI: 10.1152/ajplung.00272.2013.Peer-Reviewed Original ResearchConceptsSepsis-induced lung injuryPeripheral blood mononuclear cellsPrimary mouse lung endothelial cellsLethality of sepsisLevels of lungSystemic inflammatory responsePathogenesis of sepsisBlood mononuclear cellsCurrent medical careEffective therapeutic strategyRelevant animal modelsMitochondrial functionLung endothelial cellsNew diagnostic markersMitochondrial biogenesisAction of SIRT1Mouse lung endothelial cellsLung injurySeptic patientsNonseptic controlsMononuclear cellsSpecific therapyInflammatory responseSepsisTherapeutic strategies
2012
Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin
Tejera P, Meyer NJ, Chen F, Feng R, Zhao Y, O'Mahony DS, Li L, Sheu CC, Zhai R, Wang Z, Su L, Bajwa E, Ahasic AM, Clardy PF, Gong MN, Frank AJ, Lanken PN, Thompson BT, Christie JD, Wurfel MM, O'Keefe GE, Christiani DC. Distinct and replicable genetic risk factors for acute respiratory distress syndrome of pulmonary or extrapulmonary origin. Journal Of Medical Genetics 2012, 49: 671. PMID: 23048207, PMCID: PMC3654537, DOI: 10.1136/jmedgenet-2012-100972.Peer-Reviewed Original ResearchConceptsAcute lung injuryALI/ARDSIndirect lung injuryRisk of ARDSRespiratory distress syndromeLung injuryExtrapulmonary causesDistress syndromeIndirect insultsSingle nucleotide polymorphismsStage IIAcute respiratory distress syndromeDevelopment of ARDSGenetic variantsGenetic risk factorsIll Caucasian patientsFunctional single nucleotide polymorphismsALI/Extrapulmonary injuryPulmonary sepsisPulmonary injuryExtrapulmonary originCaucasian patientsRisk factorsARDS