2023
Occupational Risk Factors for SARS-CoV-2 Seropositivity in Healthcare Workers
Fazen L, Abad Q, Smith R, Santiago R, Liu J, Wisnewski A, Redlich C. Occupational Risk Factors for SARS-CoV-2 Seropositivity in Healthcare Workers. Journal Of Occupational And Environmental Medicine 2023, 65: 521-528. PMID: 36893070, PMCID: PMC10227858, DOI: 10.1097/jom.0000000000002831.Peer-Reviewed Original ResearchConceptsHealthcare workersRisk factorsSARS-CoV-2 immunoglobulin GSARS-CoV-2 seropositivityMultivariable-adjusted logistic regressionCox proportional hazards modelVaccine-induced immunityCOVID-19 risk factorsOccupational risk factorsLongitudinal cohort studyProportional hazards modelOccupational health interventionsRole of physiciansCOVID-19 riskCohort studyHazards modelHealth interventionsInternal medicineLogistic regressionResident physiciansImmunoglobulin GPhysiciansCOVID-19 pandemicSeropositivityVaccination
2022
Changes Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals From a North American Gaming Venue
Wisnewski AV, Cantley L, Luna J, Liu J, Smith RF, Hager K, Redlich CA. Changes Over Time in COVID-19 Incidence, Vaccinations, Serum Spike IgG, and Viral Neutralizing Potential Among Individuals From a North American Gaming Venue. Journal Of Occupational And Environmental Medicine 2022, 64: 788-796. PMID: 36054278, PMCID: PMC9426317, DOI: 10.1097/jom.0000000000002617.Peer-Reviewed Original ResearchConceptsOccupational risk factorsCOVID-19 historyRisk factorsAnti-spike IgG levelsIndividual humoral responsesSerum antiviral antibodiesCOVID-19 vaccinationEnzyme-linked immunosorbent assayCOVID-19 ratesCOVID-19 incidenceSpike IgGVaccine nonrespondersVaccination statusIgG levelsVaccine responsesVaccine typesAntiviral antibodiesHumoral responseCOVID-19 casesVaccine availabilityImmunosorbent assayVaccinationInfectionMonthsParticipantsDevelopment and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses
Wisnewski AV, Liu J, Lucas C, Klein J, Iwasaki A, Cantley L, Fazen L, Luna J, Slade M, Redlich CA. Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses. PLOS ONE 2022, 17: e0262657. PMID: 35041700, PMCID: PMC8765639, DOI: 10.1371/journal.pone.0262657.Peer-Reviewed Original ResearchConceptsPlaque reduction neutralization testCOVID-19 patientsVaccine responsesRecovered COVID-19 patientsSARS-CoV-2 immunityBooster vaccine dosesMRNA vaccine responsePost-vaccine seraCompetitive ELISAEnzyme 2 (ACE2) receptorReduction neutralization testType of vaccineSARS-CoV-2 spike protein receptorSpike protein receptorVaccine seraVaccine recipientsPost vaccinationVaccinated individualsVaccine dosesViral culturePrior historyViral neutralizationNeutralization testBooster shotsPost vaccineSevere asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death
Wisnewski AV, Cooney R, Hodgson M, Giese K, Liu J, Redlich CA. Severe asthma and death in a worker using methylene diphenyl diisocyanate MDI asthma death. American Journal Of Industrial Medicine 2022, 65: 166-172. PMID: 35028957, PMCID: PMC8846433, DOI: 10.1002/ajim.23323.Peer-Reviewed Case Reports and Technical NotesConceptsCause of deathMedical recordsDiisocyanate asthmaSevere asthmaSerum IgEParaffin-embedded lung tissue sectionsWorkers' medical recordsSmooth muscle hypertrophyTotal serum IgEHallmark of asthmaSevere asthma attacksBasement membrane thickeningLung tissue sectionsPost-mortem findingsEnzyme-linked immunosorbent assayPotential chemical exposuresInflamed airwaysMucus pluggingOccupational asthmaPulmonary embolismTotal IgEAsthma deathsAsthma attacksLung pathologyAutopsy findings
2021
Reply to letter to the editor concerning Gui et al. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory
Wisnewski AV, Redlich CA. Reply to letter to the editor concerning Gui et al. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory. American Journal Of Industrial Medicine 2021, 64: 1055-1056. PMID: 34647343, DOI: 10.1002/ajim.23299.Commentaries, Editorials and LettersImmunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines
Wisnewski AV, Redlich CA, Liu J, Kamath K, Abad QA, Smith RF, Fazen L, Santiago R, Luna J, Martinez B, Baum-Jones E, Waitz R, Haynes WA, Shon JC. Immunogenic amino acid motifs and linear epitopes of COVID-19 mRNA vaccines. PLOS ONE 2021, 16: e0252849. PMID: 34499652, PMCID: PMC8428655, DOI: 10.1371/journal.pone.0252849.Peer-Reviewed Original ResearchConceptsCOVID-19 mRNA vaccine recipientsLinear epitopesSARS-CoV-2 neutralizationCOVID-19 mRNA vaccinesVaccine-induced IgGMRNA vaccine recipientsSARS-CoV-2 spike proteinDominant linear epitopeElicit IgGVaccine recipientsVaccine effectivenessMRNA vaccinesVaccination samplesImmune escapeHuman coronavirusesHealthy adultsSARS-CoVVaccine epitopesCritical epitopesAdverse responsesReverse vaccinologySpike proteinNatural infectionS2 subunitIgGAssociations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel
Zell J, Wisnewski AV, Liu J, Klein J, Lucas C, Slade M, Iwasaki A, Redlich CA. Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel. PLOS ONE 2021, 16: e0251114. PMID: 34460832, PMCID: PMC8405017, DOI: 10.1371/journal.pone.0251114.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Live SARS-CoV-2Moderate SARS-CoV-2SARS-CoV-2 seroprevalenceWork-related risk factorsTransportation-related occupationsSerum IgG levelsAntigen-specific IgGIgG seropositivity rateBiomarkers of infectionSARS-CoV-2 spikeCOVID-19 exposureUS National Guard soldiersMilitary personnelIgG levelsSeropositivity rateHumoral responseSerum IgGViral exposureBlack raceRisk factorsOdds ratioStudy populationNational Guard soldiersDemographic dataHuman IgG and IgA responses to COVID-19 mRNA vaccines
Wisnewski AV, Luna J, Redlich CA. Human IgG and IgA responses to COVID-19 mRNA vaccines. PLOS ONE 2021, 16: e0249499. PMID: 34133415, PMCID: PMC8208542, DOI: 10.1371/journal.pone.0249499.Peer-Reviewed Original ResearchConceptsCOVID-19 mRNA vaccinesAntigen-specific IgGMRNA vaccinesIgG levelsCOVID-19 mRNA vaccinationAntigen-specific IgG levelsInitial vaccine doseAntigen-specific IgASARS-CoV-2More rapid declineSecond vaccineVaccine doseMRNA vaccinationIgA responsesSerum levelsVaccine dosesSpecific IgGNatural immunityViral neutralizationIgAVaccinePeak levelsIgGVaccinationHuman IgG
2020
Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology
Wisnewski AV, Liu J, Redlich CA. Analysis of Lung Gene Expression Reveals a Role for Cl- channels in Diisocyanate Induced Airway Eosinophilia in a Mouse Model of Asthma Pathology. American Journal Of Respiratory Cell And Molecular Biology 2020, 0: 25-35. PMID: 32101465, PMCID: PMC7328250, DOI: 10.1165/rcmb.2019-0400oc.Peer-Reviewed Original ResearchConceptsRespiratory tract exposureAirway eosinophiliaMonocytes/macrophagesMouse modelGene expressionGene transcriptsBiological pathwaysAsthma pathologyUpregulated gene transcriptsIgE-independent mechanismsLung gene expressionLung tissue gene expressionCause of asthmaBALB/cTransgenic B cellsTissue gene expressionExpression changesDiisocyanate asthmaSensitized workersAsthma pathogenesisAirway fluidDeficient miceMRNA microarrayEosinophiliaB cells
2017
Polymerization of hexamethylene diisocyanate in solution and a 260.23 m/z [M+H]+ ion in exposed human cells
Wisnewski AV, Liu J, Redlich CA, Nassar AF. Polymerization of hexamethylene diisocyanate in solution and a 260.23 m/z [M+H]+ ion in exposed human cells. Analytical Biochemistry 2017, 543: 21-29. PMID: 29175138, PMCID: PMC5826792, DOI: 10.1016/j.ab.2017.11.017.Peer-Reviewed Original ResearchConceptsHexamethylene diisocyanateCollision-induced dissociation (CID) fragmentation patternsNucleophilic additionImportant industrial chemicalPrimary aminesFragmentation patternsO groupLC-MS/MSLC-MS/MS analysisLC-MSReaction productsIonsMS analysisFormula CIndustrial chemicalsDiisocyanatePolymerizationPolymersReaction targetWaterSolutionAminesDefinitive characterizationMoleculesDimersReaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy
Wisnewski AV, Kanyo J, Asher J, Goodrich JA, Barnett G, Patrylak L, Liu J, Redlich CA, Nassar AF. Reaction products of hexamethylene diisocyanate vapors with “self” molecules in the airways of rabbits exposed via tracheostomy. Xenobiotica 2017, 48: 488-497. PMID: 28489470, PMCID: PMC5863241, DOI: 10.1080/00498254.2017.1329569.Peer-Reviewed Original ResearchConceptsCollision-induced dissociation (CID) fragmentation patternsReaction productsLower airwaysChemical reactivityLow molecular weight fractionWeight fractionHigh molecular weight fractionAliphatic diisocyanateMolecular weight fractionFragmentation patternsHexamethylenediisocyanateLC-MSHDI vaporAirways of rabbitsBronchoalveolar lavage fluidRabbit bronchoalveolar lavage fluidMoleculesDiisocyanate vaporsMs. 4Albumin. 5Occupational asthmaReactivityBAL fluidAsthma pathogenesisLavage fluid
2014
Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up
Gui W, Wisnewski AV, Neamtiu I, Gurzau E, Sparer JA, Stowe MH, Liu J, Slade MD, Rusu OA, Redlich CA. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up. American Journal Of Industrial Medicine 2014, 57: 1207-1215. PMID: 25266741, PMCID: PMC4198484, DOI: 10.1002/ajim.22385.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAirway ObstructionAsthma, OccupationalFemaleFollow-Up StudiesForced Expiratory VolumeHumansImmunoglobulin EImmunoglobulin GLost to Follow-UpMaleMiddle AgedOccupational ExposurePolyurethanesPrevalenceProspective StudiesTime FactorsToluene 2,4-DiisocyanateVital CapacityYoung AdultConceptsAsthma symptomsIsocyanate asthmaInception cohort studyHealth effectsCurrent asthma symptomsTDI levelsFirst yearFurther longitudinal evaluationAirflow obstructionCohort studyInception cohortOccupational asthmaTDI exposureRespiratory healthSkin exposureLongitudinal evaluationAsthmaOne-yearPersonal samplingSymptomsRiskExposureFindingsFEV1Spirometry
2013
Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure
Wisnewski AV, Liu J, Redlich CA. Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure. Chemico-Biological Interactions 2013, 205: 38-45. PMID: 23791970, PMCID: PMC3767171, DOI: 10.1016/j.cbi.2013.06.005.Peer-Reviewed Original ResearchPolyisocyanates and their prepolymers
Wisnewski A, Redlich C, Mapp C. Polyisocyanates and their prepolymers. 2013, 262-275. DOI: 10.1201/b15116-20.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsPolyisocyanates and their prepolymers
Wisnewski A, Redlich C. Polyisocyanates and their prepolymers. 2013, 276-289. DOI: 10.1201/b15116-24.ChaptersPolyisocyanates and their prepolymers
Wisnewski A, Redlich C, Mapp C, I. Bernstein D. Polyisocyanates and their prepolymers. 2013, 262-275. DOI: 10.3109/9781841849256.018.Chapters
2012
Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based On Serum Levels Of HDI-Specific IgG
Wisnewski A, Stowe M, DeCamp D, Kleinsmith C, Redlich C. Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based On Serum Levels Of HDI-Specific IgG. 2012, a3221-a3221. DOI: 10.1164/ajrccm-conference.2012.185.1_meetingabstracts.a3221.Peer-Reviewed Original ResearchBiomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG
Wisnewski AV, Stowe MH, Nerlinger A, Opare-addo P, Decamp D, Kleinsmith CR, Redlich CA. Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG. Annals Of Work Exposures And Health 2012, 56: 901-910. PMID: 22449630, PMCID: PMC3471419, DOI: 10.1093/annhyg/mes024.Peer-Reviewed Original ResearchConceptsPersonal protective equipmentSkin exposureExposure surveillanceSpecific serum immunoglobulin GHexamethylene diisocyanate exposureSerum IgG levelsSerum immunoglobulin GNight shift workEnzyme-linked immunosorbentAdverse health effectsAsthma historyDiisocyanate exposureIgG levelsSerum levelsIgG titersChemical allergensPPE useImmune responseRespirator useIsocyanate exposureExposure biomarkersPractical biomarkersBasic demographicsHigh titersHygiene efforts
2011
Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses
Wisnewski AV, Xu L, Robinson E, Liu J, Redlich CA, Herrick CA. Immune sensitization to methylene diphenyl diisocyanate (MDI) resulting from skin exposure: albumin as a carrier protein connecting skin exposure to subsequent respiratory responses. Journal Of Occupational Medicine And Toxicology 2011, 6: 6. PMID: 21414210, PMCID: PMC3068988, DOI: 10.1186/1745-6673-6-6.Peer-Reviewed Original ResearchRespiratory tract inflammationImmune sensitizationSkin exposureMDI conjugationBronchoalveolar lavageInflammatory responseRespiratory tract exposureAirway inflammatory responseAcetone/olive oilSubsequent immune responseSpecific antibody productionDisease prevention effortsAlbumin conjugatesOccupational asthmaSerum levelsMDI exposureAsthma pathogenesisSerum IgGIntranasal deliveryImmune responseImmune sensitivityMurine modelPathogenic mechanismsInflammationAntibody production
2010
The 24-bp CHIT1 Exon 10 Polymorphism Is Associated With Airway Hyperresponsiveness In A Population Of Autobody Shop Workers
Ong P, Wisnewski A, Stowe M, Holm C, He X, Zheng W, Zhang C, Zhao H, Redlich C, Chupp G. The 24-bp CHIT1 Exon 10 Polymorphism Is Associated With Airway Hyperresponsiveness In A Population Of Autobody Shop Workers. 2010, a4002-a4002. DOI: 10.1164/ajrccm-conference.2010.181.1_meetingabstracts.a4002.Peer-Reviewed Original Research