2022
Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses
Wisnewski AV, Liu J, Lucas C, Klein J, Iwasaki A, Cantley L, Fazen L, Luna J, Slade M, Redlich CA. Development and utilization of a surrogate SARS-CoV-2 viral neutralization assay to assess mRNA vaccine responses. PLOS ONE 2022, 17: e0262657. PMID: 35041700, PMCID: PMC8765639, DOI: 10.1371/journal.pone.0262657.Peer-Reviewed Original ResearchConceptsPlaque reduction neutralization testCOVID-19 patientsVaccine responsesRecovered COVID-19 patientsSARS-CoV-2 immunityBooster vaccine dosesMRNA vaccine responsePost-vaccine seraCompetitive ELISAEnzyme 2 (ACE2) receptorReduction neutralization testType of vaccineSARS-CoV-2 spike protein receptorSpike protein receptorVaccine seraVaccine recipientsPost vaccinationVaccinated individualsVaccine dosesViral culturePrior historyViral neutralizationNeutralization testBooster shotsPost vaccine
2021
Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel
Zell J, Wisnewski AV, Liu J, Klein J, Lucas C, Slade M, Iwasaki A, Redlich CA. Associations of SARS-CoV-2 serum IgG with occupation and demographics of military personnel. PLOS ONE 2021, 16: e0251114. PMID: 34460832, PMCID: PMC8405017, DOI: 10.1371/journal.pone.0251114.Peer-Reviewed Original ResearchConceptsSARS-CoV-2Live SARS-CoV-2Moderate SARS-CoV-2SARS-CoV-2 seroprevalenceWork-related risk factorsTransportation-related occupationsSerum IgG levelsAntigen-specific IgGIgG seropositivity rateBiomarkers of infectionSARS-CoV-2 spikeCOVID-19 exposureUS National Guard soldiersMilitary personnelIgG levelsSeropositivity rateHumoral responseSerum IgGViral exposureBlack raceRisk factorsOdds ratioStudy populationNational Guard soldiersDemographic dataHuman IgG and IgA responses to COVID-19 mRNA vaccines
Wisnewski AV, Luna J, Redlich CA. Human IgG and IgA responses to COVID-19 mRNA vaccines. PLOS ONE 2021, 16: e0249499. PMID: 34133415, PMCID: PMC8208542, DOI: 10.1371/journal.pone.0249499.Peer-Reviewed Original ResearchConceptsCOVID-19 mRNA vaccinesAntigen-specific IgGMRNA vaccinesIgG levelsCOVID-19 mRNA vaccinationAntigen-specific IgG levelsInitial vaccine doseAntigen-specific IgASARS-CoV-2More rapid declineSecond vaccineVaccine doseMRNA vaccinationIgA responsesSerum levelsVaccine dosesSpecific IgGNatural immunityViral neutralizationIgAVaccinePeak levelsIgGVaccinationHuman IgGSARS-CoV-2 Infection Hospitalization Rate and Infection Fatality Rate Among the Non-Congregate Population in Connecticut
Mahajan S, Caraballo C, Li SX, Dong Y, Chen L, Huston SK, Srinivasan R, Redlich CA, Ko AI, Faust JS, Forman HP, Krumholz HM. SARS-CoV-2 Infection Hospitalization Rate and Infection Fatality Rate Among the Non-Congregate Population in Connecticut. The American Journal Of Medicine 2021, 134: 812-816.e2. PMID: 33617808, PMCID: PMC7895685, DOI: 10.1016/j.amjmed.2021.01.020.Peer-Reviewed Original ResearchConceptsInfection hospitalization rateInfection fatality rateHospitalization ratesFatality rateSeroprevalence estimatesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodiesSARS-CoV-2 antibodiesConnecticut Hospital AssociationNon-Hispanic black peopleProportion of deathsCoronavirus disease 2019Total infected individualsTotal hospitalizationsAdverse outcomesNon-congregate settingsHigh burdenDisease 2019Prevalence studyMost subgroupsInfected individualsHospitalizationOlder peopleHospital AssociationConnecticut DepartmentDeath
2020
Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study
Mahajan S, Srinivasan R, Redlich CA, Huston SK, Anastasio KM, Cashman L, Massey DS, Dugan A, Witters D, Marlar J, Li SX, Lin Z, Hodge D, Chattopadhyay M, Adams MD, Lee C, Rao LV, Stewart C, Kuppusamy K, Ko AI, Krumholz HM. Seroprevalence of SARS-CoV-2-Specific IgG Antibodies Among Adults Living in Connecticut: Post-Infection Prevalence (PIP) Study. The American Journal Of Medicine 2020, 134: 526-534.e11. PMID: 33130124, PMCID: PMC7598362, DOI: 10.1016/j.amjmed.2020.09.024.Peer-Reviewed Original ResearchConceptsSARS-CoV-2-specific IgG antibodiesWeighted seroprevalenceIgG antibodiesSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) antibodiesSARS-CoV-2-specific antibodiesConnecticut residentsSelf-reported adherenceImmunoglobulin G antibodiesSARS-CoV-2Symptomatic illnessSerology testingSeroprevalence studyG antibodiesPrevalence studyGeneral populationPercentage of peopleSeroprevalenceLack antibodiesMajority of respondentsAntibodiesHispanic subpopulationsConvenience sampleHispanic populationCOVID-19Risk mitigation behaviors
2019
Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report
Garshick E, Abraham JH, Baird CP, Ciminera P, Downey GP, Falvo MJ, Hart JE, Jackson DA, Jerrett M, Kuschner W, Helmer DA, Jones KD, Krefft SD, Mallon T, Miller RF, Morris MJ, Proctor SP, Redlich CA, Rose CS, Rull RP, Saers J, Schneiderman AI, Smith NL, Yiallouros P, Blanc PD. Respiratory Health after Military Service in Southwest Asia and Afghanistan. An Official American Thoracic Society Workshop Report. Annals Of The American Thoracic Society 2019, 16: e1-e16. PMID: 31368802, PMCID: PMC6774741, DOI: 10.1513/annalsats.201904-344ws.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsConstrictive bronchiolitisAirway diseaseRespiratory healthOfficial American Thoracic Society Workshop ReportRespiratory tract findingsRespiratory tract abnormalitiesAdverse health conditionsParticulate matter effectsU.S. military personnelLung biopsyLung functionPulmonary functionCase seriesPathologic findingsTract abnormalitiesInhalational exposurePhysiologic changesClinical characterizationAmerican Thoracic Society International ConferenceEpidemiologic studiesBronchiolitisLongitudinal assessmentDeployment exposuresHealth conditionsMore frequent encountersThe Occupational Burden of Nonmalignant Respiratory Diseases. An Official American Thoracic Society and European Respiratory Society Statement
Blanc PD, Annesi-Maesano I, Balmes JR, Cummings KJ, Fishwick D, Miedinger D, Murgia N, Naidoo RN, Reynolds CJ, Sigsgaard T, Torén K, Vinnikov D, Redlich CA. The Occupational Burden of Nonmalignant Respiratory Diseases. An Official American Thoracic Society and European Respiratory Society Statement. American Journal Of Respiratory And Critical Care Medicine 2019, 199: 1312-1334. PMID: 31149852, PMCID: PMC6543721, DOI: 10.1164/rccm.201904-0717st.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsNonmalignant respiratory diseasesChronic obstructive pulmonary diseaseObstructive pulmonary diseasePopulation attributable fractionChronic respiratory diseasesRespiratory diseaseWorkplace exposuresPulmonary diseaseHypersensitivity pneumonitisAttributable fractionOccupational burdenOfficial American Thoracic SocietyEuropean Respiratory Society statementCommunity-acquired pneumoniaGranulomatous lung diseaseIdiopathic pulmonary fibrosisPopulation-based studyIncidence rate ratiosPulmonary alveolar proteinosisBurden of diseaseAmerican Thoracic SocietyWorking-age adultsPublic health awarenessAirway diseaseChronic bronchitis
2017
Injury, illness, and disability risk in American seafarers
Lefkowitz RY, Slade MD, Redlich CA. Injury, illness, and disability risk in American seafarers. American Journal Of Industrial Medicine 2017, 61: 120-129. PMID: 29250811, DOI: 10.1002/ajim.22802.Peer-Reviewed Original ResearchMeSH KeywordsAdultDatabases, FactualFemaleGastrointestinal DiseasesHumansLogistic ModelsMaleMiddle AgedNaval MedicineOccupational DiseasesOccupational InjuriesOdds RatioRespiratory Tract DiseasesRetrospective StudiesRiskShipsSkin DiseasesStomatognathic DiseasesTelemedicineTransportationUnited StatesConceptsDisability riskHigher disability riskOverall injury rateLogistic regression modelingResultant disabilityRisk factorsHigh riskIllness incidenceInjury ratesPreventive interventionsMedical careIllness ratesInjuryTelemedicine databaseIllnessRegression modelingEssential workforceDescriptive statistical methodsRiskAdditional researchDisabilityIncidenceCareIncidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry
Collins JJ, Anteau S, Conner PR, Cassidy LD, Doney B, Wang ML, Kurth L, Carson M, Molenaar D, Redlich CA, Storey E. Incidence of Occupational Asthma and Exposure to Toluene Diisocyanate in the United States Toluene Diisocyanate Production Industry. Journal Of Occupational And Environmental Medicine 2017, 59: s22-s27. PMID: 29200135, PMCID: PMC5763544, DOI: 10.1097/jom.0000000000000890.Peer-Reviewed Original ResearchMedical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States
Cassidy LD, Doney B, Wang ML, Kurth L, Conner PR, Collins JJ, Carson M, Molenaar D, Redlich CA, Storey E. Medical Monitoring for Occupational Asthma Among Toluene Diisocyanate Production Workers in the United States. Journal Of Occupational And Environmental Medicine 2017, 59: s13-s21. PMID: 29200134, PMCID: PMC5728423, DOI: 10.1097/jom.0000000000001197.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAsthma, OccupationalChemical IndustryEnvironmental MonitoringFemaleForced Expiratory VolumeHumansMaleMiddle AgedOccupational ExposurePopulation SurveillanceProgram EvaluationReferral and ConsultationSpirometrySurveys and QuestionnairesSymptom AssessmentToluene 2,4-DiisocyanateUnited StatesYoung AdultConceptsLung function criteriaOccupational health programWeb-based data collection systemTDI workersOccupational asthmaPossible asthmaStudy protocolHealth outcomesMultidisciplinary teamHealth programsMedical monitoringAsthmaFurther evaluationEligible workersFurther assessmentResearch protocolPotential casesSubsequent evaluationProduction workersSymptomsToluene diisocyanateWorkersEvaluationImproving the asthma disparity gap with legal advocacy? A qualitative study of patient-identified challenges to improve social and environmental factors that contribute to poorly controlled asthma
Harris DA, Mainardi A, Iyamu O, Rosenthal MS, Bruce RD, Pisani MA, Redlich CA. Improving the asthma disparity gap with legal advocacy? A qualitative study of patient-identified challenges to improve social and environmental factors that contribute to poorly controlled asthma. Journal Of Asthma 2017, 55: 924-932. PMID: 28872933, DOI: 10.1080/02770903.2017.1373393.Peer-Reviewed Original ResearchConceptsPoor symptom controlSymptom controlAsthma Control Test scoresCommon barriersCommunity health centersWork-related symptomsEnvironmental risk factorsPercent of participantsCommunity-engaged approachAsthmatic adultsAsthma controlRisk factorsAsthma triggersHealth centersImproved outcomesMedical careDisparity gapStudy participantsPerson interviewsLack of awarenessAsthmaPatientsConstant comparative methodEnvironmental factorsAdults
2016
Patterns of Energy Drink Use and Associated Symptoms Among a Population of Connecticut Factory Workers
Pensa MA, Galusha DH, Stowe MH, Lefkowitz RY, Redlich CA. Patterns of Energy Drink Use and Associated Symptoms Among a Population of Connecticut Factory Workers. Journal Of Occupational And Environmental Medicine 2016, 58: e188-e190. PMID: 27158968, DOI: 10.1097/jom.0000000000000728.Peer-Reviewed Original Research
2015
Risk factors for merchant seafarer repatriation due to injury or illness at sea
Lefkowitz RY, Slade MD, Redlich CA. Risk factors for merchant seafarer repatriation due to injury or illness at sea. International Maritime Health 2015, 66: 61-66. PMID: 26119673, DOI: 10.5603/imh.2015.0016.Peer-Reviewed Original ResearchConceptsRisk factorsLogistic regressionModifiable risk factorsSignificant risk factorsFrequent causeGastrointestinal illnessSerious outcomesIllness casesBack injuriesInjuryIllnessSeafarer injuryTelemedicine databaseMajor causeStudy periodDescriptive statisticsYear periodFuture studiesCauseFactorsRegressionCohortStudy“Injury, illness, and work restriction in merchant seafarers”
Lefkowitz RY, Slade MD, Redlich CA. “Injury, illness, and work restriction in merchant seafarers”. American Journal Of Industrial Medicine 2015, 58: 688-696. PMID: 25939921, DOI: 10.1002/ajim.22459.Peer-Reviewed Original Research
2014
Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up
Gui W, Wisnewski AV, Neamtiu I, Gurzau E, Sparer JA, Stowe MH, Liu J, Slade MD, Rusu OA, Redlich CA. Inception cohort study of workers exposed to toluene diisocyanate at a polyurethane foam factory: Initial one‐year follow‐up. American Journal Of Industrial Medicine 2014, 57: 1207-1215. PMID: 25266741, PMCID: PMC4198484, DOI: 10.1002/ajim.22385.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollutants, OccupationalAirway ObstructionAsthma, OccupationalFemaleFollow-Up StudiesForced Expiratory VolumeHumansImmunoglobulin EImmunoglobulin GLost to Follow-UpMaleMiddle AgedOccupational ExposurePolyurethanesPrevalenceProspective StudiesTime FactorsToluene 2,4-DiisocyanateVital CapacityYoung AdultConceptsAsthma symptomsIsocyanate asthmaInception cohort studyHealth effectsCurrent asthma symptomsTDI levelsFirst yearFurther longitudinal evaluationAirflow obstructionCohort studyInception cohortOccupational asthmaTDI exposureRespiratory healthSkin exposureLongitudinal evaluationAsthmaOne-yearPersonal samplingSymptomsRiskExposureFindingsFEV1Spirometry
2013
Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure
Wisnewski AV, Liu J, Redlich CA. Connecting glutathione with immune responses to occupational methylene diphenyl diisocyanate exposure. Chemico-Biological Interactions 2013, 205: 38-45. PMID: 23791970, PMCID: PMC3767171, DOI: 10.1016/j.cbi.2013.06.005.Peer-Reviewed Original Research
2012
Skin and respiratory symptoms among workers with suspected work-related disease
Arrandale V, Kudla I, Kraut A, Scott J, Tarlo S, Redlich C, Holness D. Skin and respiratory symptoms among workers with suspected work-related disease. Occupational Medicine 2012, 62: 420-426. PMID: 22915563, DOI: 10.1093/occmed/kqs133.Peer-Reviewed Original ResearchConceptsWork-related skinHistory of eczemaRespiratory symptomsConcurrent skinSkin outcomesRespiratory diseaseWork-related skin diseaseMultiple logistic regression modelInterviewer-administered questionnaireWork-related respiratory diseaseImpaired barrier functionWork-related diseasesLogistic regression modelsCurrent smokingSmoking habitsMean ageOccupational exposureRespirator useGreater oddsSkin diseasesHealth historySymptomsMost subjectsBarrier functionDiseaseBiomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG
Wisnewski AV, Stowe MH, Nerlinger A, Opare-addo P, Decamp D, Kleinsmith CR, Redlich CA. Biomonitoring Hexamethylene Diisocyanate (HDI) Exposure Based on Serum Levels of HDI-Specific IgG. Annals Of Work Exposures And Health 2012, 56: 901-910. PMID: 22449630, PMCID: PMC3471419, DOI: 10.1093/annhyg/mes024.Peer-Reviewed Original ResearchConceptsPersonal protective equipmentSkin exposureExposure surveillanceSpecific serum immunoglobulin GHexamethylene diisocyanate exposureSerum IgG levelsSerum immunoglobulin GNight shift workEnzyme-linked immunosorbentAdverse health effectsAsthma historyDiisocyanate exposureIgG levelsSerum levelsIgG titersChemical allergensPPE useImmune responseRespirator useIsocyanate exposureExposure biomarkersPractical biomarkersBasic demographicsHigh titersHygiene effortsSkin symptoms in bakery and auto body shop workers: associations with exposure and respiratory symptoms
Arrandale V, Meijster T, Pronk A, Doekes G, Redlich CA, Holness DL, Heederik D. Skin symptoms in bakery and auto body shop workers: associations with exposure and respiratory symptoms. International Archives Of Occupational And Environmental Health 2012, 86: 167-175. PMID: 22411214, PMCID: PMC3555349, DOI: 10.1007/s00420-012-0760-x.Peer-Reviewed Original ResearchConceptsAuto body shop workersExposure-response relationshipRespiratory symptomsSkin symptomsItchy skinShop workersBakery workersPossible exposure-response relationshipSignificant exposure-response associationsExposure-response associationsRespiratory outcomesMean ageDry skinSkin exposureSymptomsAverage exposureStatistical significanceWheat allergensSkinExposureAssociationPrevious studiesResultsDataMethodsDataWorkers
2011
Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs
Rockwell S, Liu Y, Mayne ST, Redlich CA. Subclinical vitamin A deficiency does not increase development of tumors in irradiated or unirradiated lungs. Experimental Biology And Medicine 2011, 236: 1173-1179. PMID: 21844122, PMCID: PMC3207150, DOI: 10.1258/ebm.2011.011082.Peer-Reviewed Original ResearchConceptsWhole lung irradiationSubclinical vitaminSpontaneous lung metastasesLung metastasesLung tumorsVitamin ALung irradiationTumor cellsLow vitaminDeficient dietSubcutaneous tumorsPossible modifiable risk factorsSeverity of pneumonitisModifiable risk factorsRadiation-induced pneumonitisEnhancement of metastasisImpact of vitaminDose-dependent increaseLevels of retinolGrowth of tumorsDevelopment of tumorsDose-response curveLung injuryLung levelsPrimary cancer