2010
The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice
Leviel F, Hübner CA, Houillier P, Morla L, Moghrabi S, Brideau G, Hatim H, Parker MD, Kurth I, Kougioumtzes A, Sinning A, Pech V, Riemondy KA, Miller RL, Hummler E, Shull GE, Aronson PS, Doucet A, Wall SM, Chambrey R, Eladari D. The Na+-dependent chloride-bicarbonate exchanger SLC4A8 mediates an electroneutral Na+ reabsorption process in the renal cortical collecting ducts of mice. Journal Of Clinical Investigation 2010, 120: 1627-1635. PMID: 20389022, PMCID: PMC2860930, DOI: 10.1172/jci40145.Peer-Reviewed Original ResearchConceptsNa-Cl cotransporterSodium transportMaintenance of euvolemiaTransepithelial NaCl absorptionDucts of miceEpithelial sodium channelIntravascular volumeIndependent Cl-/HCO3Sodium balanceMouse CCDAmiloride-sensitive epithelial sodium channelSodium absorptionExcretion resultsFluid homeostasisGenetic ablationNaCl absorptionSodium channelsMiceCl-/HCO3NaCl transportSlc4a8Genetic disruptionNovel roleHydrochlorothiazideDuct
2007
Membrane Curvature Alters the Activation Kinetics of the Epithelial Na+/H+ Exchanger, NHE3*
Alexander RT, Malevanets A, Durkan AM, Kocinsky HS, Aronson PS, Orlowski J, Grinstein S. Membrane Curvature Alters the Activation Kinetics of the Epithelial Na+/H+ Exchanger, NHE3*. Journal Of Biological Chemistry 2007, 282: 7376-7384. PMID: 17218318, DOI: 10.1074/jbc.m608557200.Peer-Reviewed Original Research
2006
Essential roles of CFEX-mediated Cl−–oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis
Aronson PS. Essential roles of CFEX-mediated Cl−–oxalate exchange in proximal tubule NaCl transport and prevention of urolithiasis. Kidney International 2006, 70: 1207-1213. PMID: 16883319, DOI: 10.1038/sj.ki.5001741.Commentaries, Editorials and LettersAnimalsAntiportersCalcium OxalateChloride-Bicarbonate AntiportersChloridesDisease Models, AnimalFormatesHomeostasisHumansHyperoxaluriaImmunohistochemistryIntestinal AbsorptionIon ExchangeKidney Tubules, ProximalMiceMice, KnockoutModels, BiologicalNephrolithiasisOocytesOxalatesSodium ChlorideSulfate TransportersXenopusRole of SLC26‐Mediated Cl−/Base Exchange in Proximal Tubule NaCl Transport
Aronson PS. Role of SLC26‐Mediated Cl−/Base Exchange in Proximal Tubule NaCl Transport. Novartis Foundation Symposia 2006, 273: 148-163. PMID: 17120766, DOI: 10.1002/0470029579.ch10.Commentaries, Editorials and Letters
2001
Essential role of NHE3 in facilitating formate-dependent NaCl absorption in the proximal tubule
Wang T, Yang C, Abbiati T, Shull G, Giebisch G, Aronson P. Essential role of NHE3 in facilitating formate-dependent NaCl absorption in the proximal tubule. American Journal Of Physiology. Renal Physiology 2001, 281: f288-f292. PMID: 11457720, DOI: 10.1152/ajprenal.2001.281.2.f288.Peer-Reviewed Original Research
1995
1994 Homer W. Smith Award. From flies to physiology--accidental findings along the trail of renal NaCl transport.
Aronson PS. 1994 Homer W. Smith Award. From flies to physiology--accidental findings along the trail of renal NaCl transport. Journal Of The American Society Of Nephrology 1995, 5: 2001-13. PMID: 7579047, DOI: 10.1681/asn.v5122001.Commentaries, Editorials and Letters
1991
A Ca-activated K channel from rabbit renal brush-border membrane vesicles in planar lipid bilayers
Zweifach A, Desir GV, Aronson PS, Giebisch GH. A Ca-activated K channel from rabbit renal brush-border membrane vesicles in planar lipid bilayers. American Journal Of Physiology 1991, 261: f187-f196. PMID: 1713419, DOI: 10.1152/ajprenal.1991.261.1.f187.Peer-Reviewed Original ResearchNa+-H+ Exchanger and Its Role in Essential Hypertension and Diabetes Mellitus
Huot S, Aronson P. Na+-H+ Exchanger and Its Role in Essential Hypertension and Diabetes Mellitus. Diabetes Care 1991, 14: 521-535. PMID: 1650693, DOI: 10.2337/diacare.14.6.521.Commentaries, Editorials and LettersConceptsDiabetes mellitusEssential hypertensionInsulin-dependent diabetes mellitusHigh blood pressureSubgroup of patientsBlood pressureHypertensionAnimal modelsPathophysiological statesTransepithelial absorptionAltered activityCellular mechanismsMellitusPatientsIntracellular pHPossible roleCell volume regulationVolume regulationCell growthRecent cDNA cloningNephropathyUbiquitous transport systems
1989
The Renal Proximal Tubule: A Model for Diversity of Anion Exchangers and Stilbene-sensitive Anion Transporters
Aronson PS. The Renal Proximal Tubule: A Model for Diversity of Anion Exchangers and Stilbene-sensitive Anion Transporters. Annual Review Of Physiology 1989, 51: 419-441. PMID: 2653190, DOI: 10.1146/annurev.ph.51.030189.002223.Commentaries, Editorials and Letters
1986
Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex.
Grassl SM, Aronson PS. Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Biological Chemistry 1986, 261: 8778-8783. PMID: 3013862, DOI: 10.1016/s0021-9258(19)84448-4.Peer-Reviewed Original Research
1985
Sodium and chloride transport across rabbit ileal brush border. II. Evidence for Cl-HCO3 exchange and mechanism of coupling
Knickelbein R, Aronson PS, Schron CM, Seifter J, Dobbins JW. Sodium and chloride transport across rabbit ileal brush border. II. Evidence for Cl-HCO3 exchange and mechanism of coupling. American Journal Of Physiology 1985, 249: g236-g245. PMID: 3927745, DOI: 10.1152/ajpgi.1985.249.2.g236.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAmilorideAnimalsAnionsBicarbonatesCarbonic AnhydrasesChloridesHydrogen-Ion ConcentrationHydroxidesIleumIn Vitro TechniquesIntestinal AbsorptionIntestinal MucosaMembrane PotentialsMicrovilliModels, BiologicalPotassiumRabbitsSodiumConceptsStimulation of ClBrush border membraneCl- uptakeInside-alkaline pH gradientCl transportCl-HCO3 exchangeRabbit ileumCoupling of NaX minMM ClBrush border vesiclesBrush borderN2-5Saturable functionMM KClNa uptakeLevel fourfoldAddition of HCO3K diffusion potentialsCarbonic anhydrase activityChloride transportUptakeParadoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes.
Guggino SE, Aronson PS. Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes. Journal Of Clinical Investigation 1985, 76: 543-547. PMID: 4031062, PMCID: PMC423858, DOI: 10.1172/jci112004.Peer-Reviewed Original ResearchConceptsLow dosesParadoxical effectUrate transportProximal tubular cellsUrate accumulationRenal urate excretionCanine renal cortexUrate retentionInside-alkaline pH gradientUricosuric drugsUrate reabsorptionRenal cortexUrate excretionTubular cellsHigh dosesCotransport pathwayDosesSame transport systemPyrazinoateLuminal membraneUrate uptakeAnion exchange pathwayDrugsMicrovillus membrane vesicles
1983
Mechanisms of active H+ secretion in the proximal tubule
Aronson PS. Mechanisms of active H+ secretion in the proximal tubule. American Journal Of Physiology 1983, 245: f647-f659. PMID: 6318566, DOI: 10.1152/ajprenal.1983.245.6.f647.Commentaries, Editorials and Letters