2002
Renal expression of novel Na+/H+exchanger isoform NHE8
Goyal S, Heuvel G, Aronson PS. Renal expression of novel Na+/H+exchanger isoform NHE8. American Journal Of Physiology. Renal Physiology 2002, 284: f467-f473. PMID: 12409279, DOI: 10.1152/ajprenal.00352.2002.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acid SequenceAnimalsAntibody SpecificityCation Transport ProteinsCOS CellsDrosophila ProteinsHumansImmunoblottingIn Situ HybridizationKidneyMembrane ProteinsMiceMicrovilliMolecular Sequence DataOrgan SpecificityProtein IsoformsRatsRNA, MessengerSequence AlignmentSequence Analysis, DNASequence Homology, Amino AcidSodium-Hydrogen Exchanger 1Sodium-Hydrogen ExchangersTransfectionConceptsProximal tubulesComplete open reading frameProximal tubule localizationRat renal cortexAmino acid identityOpen reading frameRenal expressionCortical tubulesRenal cortexOuter stripeOuter medullaNull miceMammalian orthologsWestern blotDrosophila melanogasterMouse kidneyMedullaMembrane ion transportProtein expressionAcid identityNHE8CortexMammalian isoformsReading frameNHE isoforms
1995
Ontogeny of rabbit renal cortical NHE3 and NHE1: effect of glucocorticoids
Baum M, Biemesderfer D, Gentry D, Aronson PS. Ontogeny of rabbit renal cortical NHE3 and NHE1: effect of glucocorticoids. American Journal Of Physiology 1995, 268: f815-f820. PMID: 7771509, DOI: 10.1152/ajprenal.1995.268.5.f815.Peer-Reviewed Original ResearchConceptsProximal tubulesNHE1 mRNABicarbonate absorptionNHE3 mRNA abundanceDaily subcutaneous administrationAdult animalsAdministration of glucocorticoidsEffects of glucocorticoidsNHE3 protein abundanceNeonatal proximal tubuleDays of ageRenal maturationSubcutaneous administrationRenal cortexNeonatal rabbitsCortical developmentProtein abundanceRate of maturationGlucocorticoidsNHE3 mRNAAntiporter activityApical membraneNHE3Lower ratesTubules
1992
Immunocytochemical characterization of Na(+)-H+ exchanger isoform NHE-1 in rabbit kidney
Biemesderfer D, Reilly RF, Exner M, Igarashi P, Aronson PS. Immunocytochemical characterization of Na(+)-H+ exchanger isoform NHE-1 in rabbit kidney. American Journal Of Physiology 1992, 263: f833-f840. PMID: 1279986, DOI: 10.1152/ajprenal.1992.263.5.f833.Peer-Reviewed Original ResearchConceptsNHE-1 proteinNHE-1Rabbit kidneyDistal convoluted tubuleMultiple nephron segmentsThick ascending limbWestern blot analysisRenal cortexRabbit renal cortexConvoluted tubulesProximal tubulesAscending limbRabbit nephronTubule cellsGuinea pigsLLC-PK1 cellsNephron segmentsIndirect immunofluorescenceKidneyImmunocytochemical characterizationPrincipal cellsExchanger isoformsBlot analysisFusion proteinAntibodies
1989
Effects of acetazolamide on Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex.
Soleimani M, Aronson PS. Effects of acetazolamide on Na+-HCO-3 cotransport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Clinical Investigation 1989, 83: 945-951. PMID: 2921327, PMCID: PMC303770, DOI: 10.1172/jci113980.Peer-Reviewed Original ResearchMeSH Keywords4,4'-Diisothiocyanostilbene-2,2'-Disulfonic Acid4-Acetamido-4'-isothiocyanatostilbene-2,2'-disulfonic AcidAcetatesAcetazolamideAmmoniaAnimalsBicarbonatesBiological TransportCarrier ProteinsCell MembraneHydrogen-Ion ConcentrationKidney CortexMaleRabbitsSodiumSodium-Bicarbonate Symporters
1986
Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex.
Grassl SM, Aronson PS. Na+/HCO3-co-transport in basolateral membrane vesicles isolated from rabbit renal cortex. Journal Of Biological Chemistry 1986, 261: 8778-8783. PMID: 3013862, DOI: 10.1016/s0021-9258(19)84448-4.Peer-Reviewed Original ResearchChapter 4 Molecular Properties and Physiological Roles of the Renal Na+-H+ Exchanger
Aronson P, Igarashi P. Chapter 4 Molecular Properties and Physiological Roles of the Renal Na+-H+ Exchanger. Current Topics In Membranes 1986, 26: 57-75. DOI: 10.1016/s0070-2161(08)60726-1.Chapters
1985
Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes.
Guggino SE, Aronson PS. Paradoxical effects of pyrazinoate and nicotinate on urate transport in dog renal microvillus membranes. Journal Of Clinical Investigation 1985, 76: 543-547. PMID: 4031062, PMCID: PMC423858, DOI: 10.1172/jci112004.Peer-Reviewed Original ResearchConceptsLow dosesParadoxical effectUrate transportProximal tubular cellsUrate accumulationRenal urate excretionCanine renal cortexUrate retentionInside-alkaline pH gradientUricosuric drugsUrate reabsorptionRenal cortexUrate excretionTubular cellsHigh dosesCotransport pathwayDosesSame transport systemPyrazinoateLuminal membraneUrate uptakeAnion exchange pathwayDrugsMicrovillus membrane vesicles
1984
Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesicles
Seifter JL, Knickelbein R, Aronson PS. Absence of Cl-OH exchange and NaCl cotransport in rabbit renal microvillus membrane vesicles. American Journal Of Physiology 1984, 247: f753-f759. PMID: 6093589, DOI: 10.1152/ajprenal.1984.247.5.f753.Peer-Reviewed Original Research
1983
Urate transport via anion exchange in dog renal microvillus membrane vesicles
Kahn AM, Aronson PS. Urate transport via anion exchange in dog renal microvillus membrane vesicles. American Journal Of Physiology 1983, 244: f56-f63. PMID: 6849384, DOI: 10.1152/ajprenal.1983.244.1.f56.Peer-Reviewed Original ResearchConceptsDose-response curveP-aminohippurateUrate transportRenal microvillus membrane vesiclesUptake of PAHDog renal cortexMicrovillus membrane vesiclesAnion reabsorptionRenal cortexProximal tubulesTransport of urateUrateBrush border membrane vesiclesMembrane vesiclesUrate uptakePAH uptakeExternal ClPresent studyBorder membrane vesicles
1982
Glucose and alanine inhibition of phosphate transport in renal microvillus membrane vesicles
Barrett PQ, Aronson PS. Glucose and alanine inhibition of phosphate transport in renal microvillus membrane vesicles. American Journal Of Physiology 1982, 242: f126-f131. PMID: 7065130, DOI: 10.1152/ajprenal.1982.242.2.f126.Peer-Reviewed Original Research
1980
pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles.
Blomstedt J, Aronson P. pH gradient-stimulated transport of urate and p-aminohippurate in dog renal microvillus membrane vesicles. Journal Of Clinical Investigation 1980, 65: 931-934. PMID: 7358852, PMCID: PMC434483, DOI: 10.1172/jci109748.Peer-Reviewed Original ResearchConceptsMembrane vesiclesP-aminohippurateMicrovillus membrane vesiclesTransport of urateRenal microvillus membrane vesiclesSecondary active solute transportPH gradient-stimulated uptakeTransmembrane pH gradientTransient accumulationValinomycin-induced K+ diffusion potentialPH gradientProximal tubulesVesiclesRenal cortexUrate reabsorptionElectrochemical gradientCarrier-mediated processEpithelial membranesK+ diffusion potentialLevel of uptakeUrateHarmaline inhibition of Na-dependent transport in renal microvillus membrane vesicles
Aronson P, Bounds S. Harmaline inhibition of Na-dependent transport in renal microvillus membrane vesicles. American Journal Of Physiology 1980, 238: f210-f217. PMID: 7369363, DOI: 10.1152/ajprenal.1980.238.3.f210.Peer-Reviewed Original ResearchConceptsAbsence of Na+Microvillus membrane vesiclesNa+ transport sitesNa+-H+ exchangeProximal tubular cellsNa-dependent transportRabbit renal cortexMembrane vesiclesNa+-coupled transportHigher drug concentrationsGlucose transportNa+-dependent glucose transportRate of Na+ uptakePhlorizin bindingRenal microvillus membrane vesiclesNa+ activityRenal cortexLuminal membraneNa+ transportTubular cellsDrug concentrationsAlanine transportAmino acid fluxAbsence of NaClHarmaline
1979
Dissociation of proximal tubular glucose and Na+ reabsorption by amphotericin B
Aronson PS, Hayslett JP, Kashgarian M. Dissociation of proximal tubular glucose and Na+ reabsorption by amphotericin B. American Journal Of Physiology 1979, 236: f392-f397. PMID: 434214, DOI: 10.1152/ajprenal.1979.236.4.f392.Peer-Reviewed Original ResearchConceptsAmphotericin BGlucose reabsorptionProximal tubulesNecturus proximal tubuleGlucose uptakeTubular glucose reabsorptionStopped-flow microperfusionRenal cortexRabbit renal cortexTubular lumenReabsorptionLuminal membraneGlucoseMicrovillus membrane vesiclesTubulesUptakeAmphotericinMembrane vesicle preparationsMicroperfusion
1975
The Na+ gradient-dependent transport of D-glucose in renal brush border membranes.
Aronson P, Sacktor B. The Na+ gradient-dependent transport of D-glucose in renal brush border membranes. Journal Of Biological Chemistry 1975, 250: 6032-6039. PMID: 1150669, DOI: 10.1016/s0021-9258(19)41154-x.Peer-Reviewed Original ResearchConceptsRenal brush border membraneBrush border membraneD-glucose transportNa+ gradientUptake of D-glucoseD-glucose uptakeBorder membraneTransport of D-glucoseNa+-dependent transportRabbit renal cortexD-glucoseLuminal membraneRenal cortexNa+-dependent transport systemIntact preparationsNa+-independent systemCis-stimulationPhysiological concentrations of D-glucoseD-glucose transport systemStimulatory effectConcentrations of sugarsBrush border membrane vesiclesNa+ effectMembranes in vitro
1974
Transport of d-glucose by brush border membranes isolated from the renal cortex
Aronson P, Sacktor B. Transport of d-glucose by brush border membranes isolated from the renal cortex. Biochimica Et Biophysica Acta 1974, 356: 231-243. PMID: 4855244, DOI: 10.1016/0005-2736(74)90286-7.Peer-Reviewed Original ResearchConceptsRate of D-glucose uptakeD-glucose uptakeUptake of D-glucoseEfflux of D-glucoseD-glucoseBrush border membraneRenal cortexD-glucose transportBorder membraneNa+-free mediumEffective model systemNa+ gradient hypothesisTransport of D-glucoseGradient hypothesisRabbit renal cortexConcentrations of D-glucoseAbsence of Na+Renal brush border membraneIsolated renal brush border membranesMembrane vesiclesRenal brush borderNa+-freeD-galactoseIntact preparationsBrush border membrane vesicles
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