Efficacy and safety of lenacapavir, teropavimab, and zinlirvimab: week-26 primary outcome results from a multicentre, open-label, randomised, active-controlled, phase 2 study
Ogbuagu O, Gaur A, McMahon J, Gorgos L, Morales-Ramirez J, Workowski K, Brunetta J, Mponponsuo K, Collins S, VanderVeen L, Zhang N, Huang H, Baeten J, Eron J. Efficacy and safety of lenacapavir, teropavimab, and zinlirvimab: week-26 primary outcome results from a multicentre, open-label, randomised, active-controlled, phase 2 study. The Lancet Microbe 2026, 7: 101283. PMID: 41720146, DOI: 10.1016/j.lanmic.2025.101283.Peer-Reviewed Original Research
ConceptsPhase 2 studyHIV-1 RNA concentrationsOral antiretroviral therapyAntiretroviral therapyAdverse eventsHIV-1Week-26Open-labelDrug-related grade 3Treatment-emergent adverse eventsMaintained virologic suppressionPhase 1b studyCD4 cell countHIV-1 RNAHIV-1 treatmentSerious adverse eventsInjection site reactionsTwice-yearlyVirologic suppressionBaseline regimenActive-controlledPrimary endpointSecondary endpointsLenacapavirVirological data