Jessica Tuan, MD, MS, AAHIVS
Assistant Professor of Medicine (Infectious Diseases)Cards
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Associate Director, Yale Antivirals & Vaccines Research Program, Infectious Diseases
Contact Info
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Associate Director, Yale Antivirals & Vaccines Research Program, Infectious Diseases
Contact Info
Appointments
Additional Titles
Affiliated Faculty, Yale Institute for Global Health
Associate Director, Yale Antivirals & Vaccines Research Program, Infectious Diseases
Contact Info
About
Titles
Assistant Professor of Medicine (Infectious Diseases)
Affiliated Faculty, Yale Institute for Global Health; Associate Director, Yale Antivirals & Vaccines Research Program, Infectious Diseases
Biography
Dr. Tuan's underlying interests focus on global health through the lens of healthcare infrastructure and social justice; the intersection of how life is impacted by infectious diseases, geography, and society; and the syndromes seen in tropical medicine.
She completed her Bachelor of Science and Master of Science degrees in Biomedical Engineering at Johns Hopkins University and Yale University, respectively. She graduated from Chicago Medical School. She completed Internal Medicine Residency at University of Connecticut School of Medicine and Infectious Diseases Fellowship at Yale School of Medicine.
She is the Associate Director of the Yale Antivirals & Vaccines Research Program. She is an Assistant Professor of Medicine in Infectious Diseases at Yale School of Medicine. She is a Core Faculty member of the Donaldson Firm, providing care for patients with HIV, infectious diseases, and other medical conditions, at Yale-New Haven Hospital.
She is a Principal Investigator for the following Yale School of Medicine research studies: 1) Evaluating Pitavastatin to Reduce Risk of Cardiovascular Disease in HIV-Infected Adults (REPRIEVE) (NIH/ACTG-funded clinical trial), 2) Pfizer mRNA Influenza vaccine clinical trial, 3) AIDS Clinical Trial Group (ACTG) STOMP Study: Trial of the Safety & Efficacy of Tecovirimat for Treatment of Human Monkeypox Virus Disease (Co-PI): 4) Qualitative Assessment of SARS-CoV-2 Immunogenicity (QUASI) after COVID-19 vaccination in People Living with HIV, 5) Outcomes of Pregnant Women Exposed to Sotrovimab for Treatment of COVID-19 in the Omicron Predominant Era (PRESTO).
She is a Sub-Investigator for the Yale Pfizer/BioNTech (adult, pediatric, booster) & Sanofi COVID-19 vaccine clinical trials. She is a Sub-Investigator for Yale School of Medicine HIV clinical trials: 1) Study to Assess the Effectiveness & Safety of Lenacapavir for HIV Pre-Exposure Prophylaxis (PURPOSE 2); 2) Evaluating the Safety & Efficacy of Bictegravir/Lenacapavir vs. Stable Baseline Regimen in Virologically Suppressed People With HIV-1 on Stable Complex Treatment Regimens, 3) Study of Broadly Neutralizing Antibodies GS-5423 & GS-2872 in Combination With Lenacapavir in Virologically Suppressed Adults With HIV-1. Her other research focus is as a Sub-Investigator for the NIH/NIMH R21 grant "HIV PrEP Perspectives of Liberian Adolescent Girls & Young Women and their Providers (PRECIOUS)," in collaboration with physicians at the John F. Kennedy Medical Center Hospital in Monrovia, Liberia.
She was awarded the Yale Institute for Global Health Leadership in Global Health Fellowship as a World Bank COVID-19 Vaccine & Primary Health Care Fellow. She was a Yale Johnson & Johnson Global Health Scholar in KwaZulu-Natal, South Africa (2022), Kigali, Rwanda (2019) and Butare, Rwanda (2017). She is a violinist in the Yale Medical Symphony Orchestra and pianist. She is a Fellow writing in The OpEd Project of the Yale Public Voices Fellowship (2023-2024).
Her medical literature has been published in Clinical Infectious Diseases, HIV Medicine, Emerging Infectious Diseases, American Journal of Tropical Medicine & Hygiene, PLOS One, BioMed Central Infectious Diseases, Rwanda Medical Journal, and British Medical Journal Case Reports.
She has been featured in The Washington Post, Newsweek, National Geographic, London Broadcasting Company News, Contagion, WTNH News 'Health Headlines,' NBC Connecticut News, News 12 Connecticut, and Hartford Courant.
Appointments
Infectious Diseases
Assistant ProfessorPrimary
Other Departments & Organizations
Education & Training
- Fellowship
- Yale University School of Medicine, Infectious Diseases (2021)
- Residency
- University of Connecticut School of Medicine, Primary Care Internal Medicine (2019)
- MD
- Chicago Medical School, Doctor of Medicine (2016)
- MS
- Yale University, Graduate School of Arts and Sciences, Biomedical Engineering (2012)
- BS
- Johns Hopkins University, Whiting School of Engineering, Biomedical Engineering (2010)
Research
Overview
Medical Subject Headings (MeSH)
- View Lab Website
Yale Antivirals & Vaccine Research Program
Research at a Glance
Yale Co-Authors
Publications Timeline
Research Interests
Onyema Ogbuagu, MBBCh, FACP, FIDSA
Anne Spichler Moffarah, MD, PhD
Lydia Aoun-Barakat, MD
Frederick Lewis Altice, MD, MA
Kavin Patel
Lauren Pischel, MD, MSc
Publications
2024
Cytomegalovirus IgG is Associated With Physical Function But Not Muscle Density in People With HIV
Abidi M, Umbleja T, Overton E, Burdo T, Flynn J, Lu M, Taron J, Schnittman S, Fitch K, Zanni M, Fichtenbaum C, Malvestutto C, Aberg J, Fulda E, Eckard A, Manne-Goehler J, Tuan J, Ribaudo H, Douglas P, Grinspoon S, Brown T, Erlandson K. Cytomegalovirus IgG is Associated With Physical Function But Not Muscle Density in People With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 95: 470-478. PMID: 38180893, PMCID: PMC10947880, DOI: 10.1097/qai.0000000000003377.Peer-Reviewed Original ResearchAltmetricConceptsHigh-sensitivity C-reactive proteinShort Physical Performance BatteryCMV IgG titersPhysical functionMuscle densityIgG titersPhysical function impairmentAtherosclerotic cardiovascular diseasePhysical Performance BatteryPoor physical functionC-reactive proteinPhysical function measuresLog-binomial regressionPhysical function dataQuantitative enzyme immunoassayPartial Spearman correlationsNadir CD4CMV IgGCytomegalovirus seropositivityFurther mechanistic studiesSPPB scoreFunction impairmentPoor outcomePrimary preventionBiomarker testingCOVID-19 Vaccine Efficacy in Participants With Weakened Immune Systems From 4 Randomized Controlled Trials
Sherman A, Tuan J, Cantos V, Adeyiga O, Mahoney S, Ortega-Villa A, Tillman A, Whitaker J, Davis A, Leav B, Hirsch I, Sadoff J, Dunkle L, Gilbert P, Janes H, Kublin J, Goepfert P, Kotloff K, Rouphael N, Falsey A, Sahly H, Sobieszczyk M, Huang Y, Neuzil K, Corey L, Grinsztejn B, Gray G, Nason M, Baden L, Gay C. COVID-19 Vaccine Efficacy in Participants With Weakened Immune Systems From 4 Randomized Controlled Trials. Clinical Infectious Diseases 2024, 79: 364-374. PMID: 38598658, PMCID: PMC11327800, DOI: 10.1093/cid/ciae192.Peer-Reviewed Original ResearchAltmetricConceptsSevere COVID-19Vaccine efficacyImmune systemBlinded phaseWell-controlled HIVPhase 3 trialSARS-CoV-2 vaccinesSevere COVID-19 casesWeakened immune systemRandomized-controlled trialsCOVID-19 vaccine efficacyRandomized controlled trialsPlacebo-controlledCross-protocol analysisImmunocompromised conditionsRandomized controlled efficacy trialPrimary seriesMedical historySymptomatic endpointsSevere diseaseConsensus panelEfficacy trialsSARS-CoV-2Nutritional disordersGeneral population
2023
Pitavastatin to Prevent Cardiovascular Disease in HIV Infection.
Grinspoon SK, Fitch KV, Zanni MV, Fichtenbaum CJ, Umbleja T, Aberg JA, Overton ET, Malvestutto CD, Bloomfield GS, Currier JS, Martinez E, Roa JC, Diggs MR, Fulda ES, Paradis K, Wiviott SD, Foldyna B, Looby SE, Desvigne-Nickens P, Alston-Smith B, Leon-Cruz J, McCallum S, Hoffmann U, Lu MT, Ribaudo HJ, Douglas PS, REPRIEVE Investigators. Pitavastatin to Prevent Cardiovascular Disease in HIV Infection. N Engl J Med 2023, 389: 687-699. PMID: 37486775, DOI: 10.1056/NEJMoa2304146.Peer-Reviewed Original ResearchLenacapavir: a twice-yearly treatment for adults with multidrug-resistant HIV infection and limited treatment options
Tuan J, Ogbuagu O. Lenacapavir: a twice-yearly treatment for adults with multidrug-resistant HIV infection and limited treatment options. Expert Review Of Anti-infective Therapy 2023, 21: 565-570. PMID: 37067160, DOI: 10.1080/14787210.2023.2203913.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsTreatment optionsMultidrug-resistant HIV infectionMultidrug-resistant HIVTreatment-emergent resistanceLimited treatment optionsClinical trial dataDrug-drug interactionsBreakthrough therapy designationHIV-1 capsid inhibitorsMechanism of actionAdherence supportCompanion drugsAntiretroviral agentsHIV infectionHIV treatmentClinical trialsLenacapavirPharmacodynamic propertiesDrug AdministrationExpert opinion sectionCapsid inhibitorsTrial dataU.S. FoodClinical usesYearly treatmentHIV risk profile and prevention needs of individuals seeking monkeypox (mpox) vaccination in an urban clinic in the U.S.: a brief report
Ogbuagu O, Sharma M, Igiraneza G, Andrews L, Tuan J, Barakat L. HIV risk profile and prevention needs of individuals seeking monkeypox (mpox) vaccination in an urban clinic in the U.S.: a brief report. BMC Infectious Diseases 2023, 23: 146. PMID: 36890468, PMCID: PMC9993362, DOI: 10.1186/s12879-023-08075-5.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsHIV risk profilesSTI riskPre-exposure prophylaxis useRisk profileMedian age 28 yearsHIV-negative respondentsHIV-negative participantsHIV-negative individualsReceptive anal intercourseModerate alcohol useAge 28 yearsCross-sectional surveySexual partner numberProphylaxis useResultsEighty-onePrEP knowledgeHIV positivityPrevention gapUrban clinicCenter clinicPrevention needsSTI historyInclusion criteriaAnal intercourseIllicit substancesOutcomes of pregnant women exposed to Sotrovimab for the treatment of COVID-19 in the BA.1 Omicron predominant era (PRESTO)
Tuan, J.J., Sharma M, Kayani J, Davis M, McManus D, Topal J, Ogbuagu O. Outcomes of pregnant women exposed to Sotrovimab for the treatment of COVID-19 in the BA.1 Omicron predominant era (PRESTO). BMC Infect Dis 23, 258 (April 2023). https://doi.org/10.1186/s12879-023-08198-9Peer-Reviewed Original ResearchAcute cytomegalovirus proctitis and epididymitis acquired via sexual transmission in an immunocompetent patient: a case report
Oyeyemi, D.M., Chan, E., Montano, M., Belzer, A., Ogbuagu, O., Zapata, H., Tuan J. Acute cytomegalovirus proctitis and epididymitis acquired via sexual transmission in an immunocompetent patient: a case report. J Med Case Reports 17, 489 (2023). https://doi.org/10.1186/s13256-023-04216-1Peer-Reviewed Case Reports and Technical Notes
2022
Acute kidney injury due to myoglobin cast nephropathy in the setting of coronavirus disease 2019-mediated rhabdomyolysis: a case report
Tuan J, Ogbuagu O, Kumar D, Altice F, Fikrig M. Acute kidney injury due to myoglobin cast nephropathy in the setting of coronavirus disease 2019-mediated rhabdomyolysis: a case report. Journal Of Medical Case Reports 2022, 16: 491. PMID: 36578087, PMCID: PMC9795945, DOI: 10.1186/s13256-022-03721-z.Peer-Reviewed Case Reports and Technical NotesCitationsAltmetricMeSH Keywords and ConceptsConceptsAcute kidney injuryCoronavirus disease 2019Kidney injuryDisease 2019Cast nephropathyEnd-organ damageRenal biopsy findingsSpectrum of diseaseBaseline 6Gastrointestinal symptomsHospital courseBiopsy findingsCase presentationAPoor appetiteRenal failureRenal functionOral intakeUrine outputInitial diagnosisCaucasian manCase reportRhabdomyolysisNephropathyAbnormal tasteOrgan systemsClinical Outcomes following Dalbavancin Administration in Patients with Barriers to Outpatient Parenteral Antimicrobial Therapy
Tuan, J., Kayani, J., Fisher, A., Kotansky, B., Dembry, L., & Datta, R. (2022). Clinical outcomes following dalbavancin administration in patients with barriers to outpatient parenteral antimicrobial therapy. Antimicrobial Stewardship & Healthcare Epidemiology, 2(1), E83. doi:10.1017/ash.2022.229Peer-Reviewed Original ResearchImportant Zoonotic Pandemics and Epidemics of the 21st Century: A Review.
Tuan, J. Important Zoonotic Pandemics and Epidemics of the 21st Century: A Review. Advances in Health and Disease, Volume 56, July 2022.Books
Clinical Trials
Current Trials
Randomized, Double-blind, Placebo-controlled, Multicenter Phase 3 Study to Assess the Efficacy, Safety And Immunogenicity of Vaccination With ExPEC9V in the Prevention ofInv asive Extraintestinal Pathogenic Escherichia coli Disease in Adults Aged 60 Years And Older with a History of Urinary Tract Infection in the Past 2 Years VAC52416BAC3001
HIC ID2000033595RoleSub InvestigatorPrimary Completion Date05/19/2025Recruiting ParticipantsGenderBothAge60+ years
Academic Achievements and Community Involvement
activity Journal of Medical Virology
Journal ServiceReviewerDetails12/17/2021 - Presentactivity Journal of Infection
Journal ServiceReviewerDetails11/15/2021 - Presentactivity British Medical Journal Case Reports
Journal ServiceReviewerDetails09/01/2020 - Presentactivity Journal of Clinical Medicine
Journal ServiceReviewerDetails11/04/2021 - Presentactivity American Journal of Tropical Medicine and Hygiene
Journal ServiceReviewerDetails06/01/2021 - Present
Clinical Care
Overview
Clinical Specialties
Board Certifications
Clinical Tropical Medicine Travelers' Health
- Certification Organization
- American Society of Tropical Medicine & Hygiene
- Original Certification Date
- 2023
Are You a Patient?
View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.
View Doctor ProfileLinks & Media
News
- June 27, 2024Source: Healthline
Dengue Fever Cases Increasing in US as CDC Issues Warning
- December 12, 2023Source: National Geographic
Don't Risk Your Holiday Plans: The Basics Still Matter for COVID and Flu
- November 07, 2023Source: Newsweek
Is There a Price and Time Limit on Human Justice, Freedom, and Dignity?
- August 25, 2023
Meet Yale Internal Medicine: Jessica Tuan, MD, MS, AAHIVS, Assistant Professor of Medicine (Infectious Diseases)
Related Links
- Fighting Words in a COVID-19 Pandemic—Combating an Era of Denialism
- Is There a Price and Time Limit on Human Justice, Freedom, and Dignity?
- Meet Yale Internal Medicine: Jessica Tuan, MD, MS, AAHIVS
- Yale Antivirals & Vaccines Research Program
- Yale OpEd Project/Public Voices Fellowship
- Ending the HIV Epidemic: What Is Past Is Not Prologue
- 6 tips to avoid getting your family sick during holiday travel
- Optimizing Treatment with Multidrug-resistant HIV Infection: a Role for Lenacapavir?
- Don't risk your holiday plans: The basics still matter for COVID and flu
- Treating Expecting Mothers With Sotrovimab for COVID-19
- Photo Exhibit Highlights YSM’s Response to COVID-19
- World Bank COVID-19 Vaccine & Primary Health Care Fellow
- Yale Global Health Scholars Program
- Yale Medical Symphony Orchestra