2018
Endothelins in inflammatory neurological diseases
D'Orléans-Juste P, Akide Ndunge O, Desbiens L, Tanowitz HB, Desruisseaux MS. Endothelins in inflammatory neurological diseases. Pharmacology & Therapeutics 2018, 194: 145-160. PMID: 30291906, PMCID: PMC6348026, DOI: 10.1016/j.pharmthera.2018.10.001.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsCentral nervous systemNeuroinflammatory processesCentral nervous system vasculitisNon-infectious inflammatory processesBlood-brain barrier levelEndothelin-1 antagonistsSynthesis of endothelinInflammatory neurological diseasesMediator/modulatorProgression of neurodegenerationPotent vasoactive compoundsNeuroinflammatory diseasesEndothelin pathwayEndothelin-1Inflammatory processClinical trialsVasoactive compoundsCardiovascular propertiesNervous systemAmino acid peptideNeurological diseasesEndothelial integrityEndothelinAlzheimer's diseaseNeurodegenerative disorders
2016
Endothelin-1 Treatment Induces an Experimental Cerebral Malaria–Like Syndrome in C57BL/6 Mice Infected with Plasmodium berghei NK65
Martins YC, Freeman BD, Ndunge O, Weiss LM, Tanowitz HB, Desruisseaux MS. Endothelin-1 Treatment Induces an Experimental Cerebral Malaria–Like Syndrome in C57BL/6 Mice Infected with Plasmodium berghei NK65. American Journal Of Pathology 2016, 186: 2957-2969. PMID: 27640146, PMCID: PMC5222963, DOI: 10.1016/j.ajpath.2016.07.020.Peer-Reviewed Original ResearchConceptsExperimental cerebral malariaEndothelin-1ET-1 treatmentC57BL/6 miceBerghei NK65Pathogenesis of ECMBlood-brain barrier leakagePlasmodium berghei ANKA infectionBlood-brain barrier permeabilitySevere malarial diseasePlasmodium berghei ANKABerghei ANKA infectionP. berghei NK65Plasmodium berghei NK65Functional capillary densityEndothelin-1 treatmentCerebral malariaMicrovascular alterationsANKA infectionBerghei ANKARed blood cellsVascular dysfunctionCerebral microvasculatureNeurological signsBarrier leakageEndothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria
Freeman BD, Martins YC, Akide-Ndunge OB, Bruno FP, Wang H, Tanowitz HB, Spray DC, Desruisseaux MS. Endothelin-1 Mediates Brain Microvascular Dysfunction Leading to Long-Term Cognitive Impairment in a Model of Experimental Cerebral Malaria. PLOS Pathogens 2016, 12: e1005477. PMID: 27031954, PMCID: PMC4816336, DOI: 10.1371/journal.ppat.1005477.Peer-Reviewed Original ResearchConceptsExperimental cerebral malariaCerebral malariaEndothelin-1Cognitive impairmentExperimental cerebral malaria modelBlood-brain barrier disruptionLong-term cognitive impairmentCerebral malaria modelEndothelin-1 administrationLife-threatening encephalopathyBerghei ANKA infectionPlasmodium falciparum infectionCerebral malaria pathogenesisBrain microvascular dysfunctionMicrovascular congestionCerebral vasoconstrictionAdjunctive therapyANKA infectionBerghei ANKAMicrovascular dysfunctionFalciparum infectionImproved survivalEndothelial activationBarrier disruptionReceptor antagonistChapter 14 Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System
Tanowitz H, Wen J, Machado F, Desruisseaux M, Robello C, Garg N. Chapter 14 Trypanosoma cruzi and Chagas Disease: Innate Immunity, ROS, and Cardiovascular System. 2016, 183-193. DOI: 10.1016/b978-0-12-801078-5.00014-5.ChaptersChagas diseaseThromboxane A2Innate immunityAnti-inflammatory factorsContribution of cytokinesTrypanosoma cruziSignificant morbidityVasoconstrictive actionEndothelin-1Nonendemic areasEndemic areasEicosanoid pathwayCardiovascular systemDiseaseNatural transmissionImmunityOxygen speciesCruziMorbidityChemokinesA2CytokinesPathogenesisLipoxinsMortality
2014
Endothelin-1 and its role in the pathogenesis of infectious diseases
Freeman BD, Machado FS, Tanowitz HB, Desruisseaux MS. Endothelin-1 and its role in the pathogenesis of infectious diseases. Life Sciences 2014, 118: 110-119. PMID: 24780317, PMCID: PMC4538933, DOI: 10.1016/j.lfs.2014.04.021.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsConceptsEndothelin-1Isoforms of endothelinRole of endothelinRickettsia conorii infectionPathogenesis of sepsisPro-inflammatory cytokinesVascular smooth muscle cellsLeukocyte adhesion moleculesSmooth muscle cellsSevere malariaVascular dysfunctionBacterial pneumoniaInflammatory mediatorsVascular tonePotent vasoconstrictorImmunomodulatory propertiesInfectious processAlveolar macrophagesPlatelet aggregationInfectious diseasesMuscle cellsEndothelinAdhesion moleculesPathogenesisChagas disease
This site is protected by hCaptcha and its Privacy Policy and Terms of Service apply