2024
Cytomegalovirus IgG is Associated With Physical Function But Not Muscle Density in People With HIV
Abidi M, Umbleja T, Overton E, Burdo T, Flynn J, Lu M, Taron J, Schnittman S, Fitch K, Zanni M, Fichtenbaum C, Malvestutto C, Aberg J, Fulda E, Eckard A, Manne-Goehler J, Tuan J, Ribaudo H, Douglas P, Grinspoon S, Brown T, Erlandson K. Cytomegalovirus IgG is Associated With Physical Function But Not Muscle Density in People With HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2024, 95: 470-478. PMID: 38180893, PMCID: PMC10947880, DOI: 10.1097/qai.0000000000003377.Peer-Reviewed Original ResearchHigh-sensitivity C-reactive proteinShort Physical Performance BatteryCMV IgG titersPhysical functionMuscle densityIgG titersPhysical function impairmentAtherosclerotic cardiovascular diseasePhysical Performance BatteryPoor physical functionC-reactive proteinPhysical function measuresLog-binomial regressionPhysical function dataQuantitative enzyme immunoassayPartial Spearman correlationsNadir CD4CMV IgGCytomegalovirus seropositivityFurther mechanistic studiesSPPB scoreFunction impairmentPoor outcomePrimary preventionBiomarker testingCOVID-19 Vaccine Efficacy in Participants With Weakened Immune Systems From 4 Randomized Controlled Trials
Sherman A, Tuan J, Cantos V, Adeyiga O, Mahoney S, Ortega-Villa A, Tillman A, Whitaker J, Davis A, Leav B, Hirsch I, Sadoff J, Dunkle L, Gilbert P, Janes H, Kublin J, Goepfert P, Kotloff K, Rouphael N, Falsey A, Sahly H, Sobieszczyk M, Huang Y, Neuzil K, Corey L, Grinsztejn B, Gray G, Nason M, Baden L, Gay C. COVID-19 Vaccine Efficacy in Participants With Weakened Immune Systems From 4 Randomized Controlled Trials. Clinical Infectious Diseases 2024, 79: 364-374. PMID: 38598658, PMCID: PMC11327800, DOI: 10.1093/cid/ciae192.Peer-Reviewed Original ResearchSevere COVID-19Vaccine efficacyImmune systemBlinded phaseWell-controlled HIVPhase 3 trialSARS-CoV-2 vaccinesSevere COVID-19 casesWeakened immune systemRandomized-controlled trialsCOVID-19 vaccine efficacyRandomized controlled trialsPlacebo-controlledCross-protocol analysisImmunocompromised conditionsRandomized controlled efficacy trialPrimary seriesMedical historySymptomatic endpointsSevere diseaseConsensus panelEfficacy trialsSARS-CoV-2Nutritional disordersGeneral population
2023
Pitavastatin to Prevent Cardiovascular Disease in HIV Infection.
Grinspoon SK, Fitch KV, Zanni MV, Fichtenbaum CJ, Umbleja T, Aberg JA, Overton ET, Malvestutto CD, Bloomfield GS, Currier JS, Martinez E, Roa JC, Diggs MR, Fulda ES, Paradis K, Wiviott SD, Foldyna B, Looby SE, Desvigne-Nickens P, Alston-Smith B, Leon-Cruz J, McCallum S, Hoffmann U, Lu MT, Ribaudo HJ, Douglas PS, REPRIEVE Investigators. Pitavastatin to Prevent Cardiovascular Disease in HIV Infection. N Engl J Med 2023, 389: 687-699. PMID: 37486775, DOI: 10.1056/NEJMoa2304146.Peer-Reviewed Original ResearchLenacapavir: a twice-yearly treatment for adults with multidrug-resistant HIV infection and limited treatment options
Tuan J, Ogbuagu O. Lenacapavir: a twice-yearly treatment for adults with multidrug-resistant HIV infection and limited treatment options. Expert Review Of Anti-infective Therapy 2023, 21: 565-570. PMID: 37067160, DOI: 10.1080/14787210.2023.2203913.Peer-Reviewed Original ResearchConceptsTreatment optionsMultidrug-resistant HIV infectionMultidrug-resistant HIVTreatment-emergent resistanceLimited treatment optionsClinical trial dataDrug-drug interactionsBreakthrough therapy designationHIV-1 capsid inhibitorsMechanism of actionAdherence supportCompanion drugsAntiretroviral agentsHIV infectionHIV treatmentClinical trialsLenacapavirPharmacodynamic propertiesDrug AdministrationExpert opinion sectionCapsid inhibitorsTrial dataU.S. FoodClinical usesYearly treatmentHIV risk profile and prevention needs of individuals seeking monkeypox (mpox) vaccination in an urban clinic in the U.S.: a brief report
Ogbuagu O, Sharma M, Igiraneza G, Andrews L, Tuan J, Barakat L. HIV risk profile and prevention needs of individuals seeking monkeypox (mpox) vaccination in an urban clinic in the U.S.: a brief report. BMC Infectious Diseases 2023, 23: 146. PMID: 36890468, PMCID: PMC9993362, DOI: 10.1186/s12879-023-08075-5.Peer-Reviewed Original ResearchConceptsHIV risk profilesSTI riskPre-exposure prophylaxis useRisk profileMedian age 28 yearsHIV-negative respondentsHIV-negative participantsHIV-negative individualsReceptive anal intercourseModerate alcohol useAge 28 yearsCross-sectional surveySexual partner numberProphylaxis useResultsEighty-onePrEP knowledgeHIV positivityPrevention gapUrban clinicCenter clinicPrevention needsSTI historyInclusion criteriaAnal intercourseIllicit substancesOutcomes of pregnant women exposed to Sotrovimab for the treatment of COVID-19 in the BA.1 Omicron predominant era (PRESTO)
Tuan, J.J., Sharma M, Kayani J, Davis M, McManus D, Topal J, Ogbuagu O. Outcomes of pregnant women exposed to Sotrovimab for the treatment of COVID-19 in the BA.1 Omicron predominant era (PRESTO). BMC Infect Dis 23, 258 (April 2023). https://doi.org/10.1186/s12879-023-08198-9Peer-Reviewed Original ResearchAcute cytomegalovirus proctitis and epididymitis acquired via sexual transmission in an immunocompetent patient: a case report
Oyeyemi, D.M., Chan, E., Montano, M., Belzer, A., Ogbuagu, O., Zapata, H., Tuan J. Acute cytomegalovirus proctitis and epididymitis acquired via sexual transmission in an immunocompetent patient: a case report. J Med Case Reports 17, 489 (2023). https://doi.org/10.1186/s13256-023-04216-1Peer-Reviewed Case Reports and Technical Notes
2022
Acute kidney injury due to myoglobin cast nephropathy in the setting of coronavirus disease 2019-mediated rhabdomyolysis: a case report
Tuan J, Ogbuagu O, Kumar D, Altice F, Fikrig M. Acute kidney injury due to myoglobin cast nephropathy in the setting of coronavirus disease 2019-mediated rhabdomyolysis: a case report. Journal Of Medical Case Reports 2022, 16: 491. PMID: 36578087, PMCID: PMC9795945, DOI: 10.1186/s13256-022-03721-z.Peer-Reviewed Case Reports and Technical NotesConceptsAcute kidney injuryCoronavirus disease 2019Kidney injuryDisease 2019Cast nephropathyEnd-organ damageRenal biopsy findingsSpectrum of diseaseBaseline 6Gastrointestinal symptomsHospital courseBiopsy findingsCase presentationAPoor appetiteRenal failureRenal functionOral intakeUrine outputInitial diagnosisCaucasian manCase reportRhabdomyolysisNephropathyAbnormal tasteOrgan systemsClinical Outcomes following Dalbavancin Administration in Patients with Barriers to Outpatient Parenteral Antimicrobial Therapy
Tuan, J., Kayani, J., Fisher, A., Kotansky, B., Dembry, L., & Datta, R. (2022). Clinical outcomes following dalbavancin administration in patients with barriers to outpatient parenteral antimicrobial therapy. Antimicrobial Stewardship & Healthcare Epidemiology, 2(1), E83. doi:10.1017/ash.2022.229Peer-Reviewed Original ResearchImportant Zoonotic Pandemics and Epidemics of the 21st Century: A Review.
Tuan, J. Important Zoonotic Pandemics and Epidemics of the 21st Century: A Review. Advances in Health and Disease, Volume 56, July 2022.BooksLong-term Quantitative Assessment of Anti-SARS-CoV-2 Spike Protein Immunogenicity (QUASI) after COVID-19 vaccination in Older People Living with HIV
Tuan J, Zapata H, Barakat L, Andrews L, Behnegar A, Kim YW, Kayani J, Mutic S, Ryall L, Turcotte B, Critch-Gilfillan T, Zhao, M, Salahuddin S, Gupta S, Sutton R, Friedland, G, Emu, B, Ogbuagu O. Long-term Quantitative Assessment of Anti-SARS-CoV-2 Spike Protein Immunogenicity (QUASI) after COVID-19 vaccination in Older People Living with HIV. BMC Infectious Diseases Journal, 22, 744 (21 September 2022).Peer-Reviewed Original Research
2021
Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDC
Brown SC, Cormier J, Tuan J, Lier AJ, McGuone D, Armstrong PM, Kaddouh F, Parikh S, Landry ML, Gobeske KT. Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019 - Volume 27, Number 8—August 2021 - Emerging Infectious Diseases journal - CDC. Emerging Infectious Diseases 2021, 27: 2042-2051. PMID: 34289334, PMCID: PMC8314835, DOI: 10.3201/eid2708.203730.Peer-Reviewed Original ResearchRace and ethnicity do not impact eligibility for remdesivir: A single-center experience
Pischel L, Walelo M, Benson J, Osborn R, Schrier R, Tuan J, Barakat L, Ogbuagu O. Race and ethnicity do not impact eligibility for remdesivir: A single-center experience. PLOS ONE 2021, 16: e0250735. PMID: 33956849, PMCID: PMC8101938, DOI: 10.1371/journal.pone.0250735.Peer-Reviewed Original ResearchConceptsClinical trialsExclusion criteriaSingle health care systemObservational cohort studySingle-center experienceClinical trial criteriaTime of presentationMedical record chartsNon-Hispanic whitesEthnic minority enrollmentSimilar ratesHealth care systemCohort studyTrial criteriaMultiple therapiesInclusion criteriaRecord chartsEthnic groupsRemdesivirCare systemTrialsSelf-identified WhiteEligibilityWhite participantsMultiple potential barriersIncreasing face-mask compliance among healthcare personnel during the coronavirus disease 2019 (COVID-19) pandemic
Datta R, Glenn K, Pellegrino A, Tuan J, Linde B, Kayani J, Patel K, Calo L, Dembry LM, Fisher A. Increasing face-mask compliance among healthcare personnel during the coronavirus disease 2019 (COVID-19) pandemic. Infection Control And Hospital Epidemiology 2021, 43: 616-622. PMID: 33938417, PMCID: PMC8144836, DOI: 10.1017/ice.2021.205.Peer-Reviewed Original ResearchA new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding?
Tuan J, Spichler-Moffarah A, Ogbuagu O. A new positive SARS-CoV-2 test months after severe COVID-19 illness: reinfection or intermittent viral shedding? BMJ Case Reports 2021, 14: e240531. PMID: 33542020, PMCID: PMC8098910, DOI: 10.1136/bcr-2020-240531.Peer-Reviewed Case Reports and Technical NotesConceptsSARS-CoV-2 RNA testSevere acute respiratory syndrome coronavirus 2Acute respiratory syndrome coronavirus 2SARS-CoV-2 reinfectionSevere COVID-19 illnessRespiratory syndrome coronavirus 2COVID-19 reinfectionLong asymptomatic periodCOVID-19 illnessSyndrome coronavirus 2Intermittent viral sheddingAsymptomatic periodViral sheddingRNA testCoronavirus 2Clinical managementPersistent infectionDisease 4Molecular testingReinfectionRNA PCRCurrent presentationPotential casesMonthsPatientsFour Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019
Brown SC, Cormier J, Tuan J, et al. Four Human Cases of Eastern Equine Encephalitis in Connecticut, USA, during a Larger Regional Outbreak, 2019. Emerging Infectious Diseases. 2021;27(8):2042-2051. doi:10.3201/eid2708.203730Peer-Reviewed Original ResearchQualitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID- 19 vaccination in older people living with HIV
Tuan JJ, Zapata H, Critch-Gilfillan, T, Ryall L, Turcotte B, Mutic S, Andrews L, Roh M, Friedland G, Barakat L, Ogbuagu O. Qualitative assessment of anti-SARS-CoV-2 spike protein immunogenicity (QUASI) after COVID-19 vaccination in older people living with HIV. HIV Medicine. 2021; 00: 1– 8. doi:10.1111/hiv.13188Peer-Reviewed Original ResearchInfectious Diseases as Mimickers of Stroke
Tuan J, Verma G, Ogbuagu O. "Infectious Diseases as Mimickers of Stroke," Storm Brain. Cardiovascular Research Trust/Hippocrates Initiative. London, UK. November 24, 2021.Books
2020
Mycobacterium marinum: nodular hand lesions after a fishing expedition
Tuan J, Spichler-Moffarah A, Ogbuagu O. Mycobacterium marinum: nodular hand lesions after a fishing expedition. BMJ Case Reports 2020, 13: e238835. PMID: 33318281, PMCID: PMC7737068, DOI: 10.1136/bcr-2020-238835.Peer-Reviewed Case Reports and Technical NotesConceptsSoft tissue infectionsDeep space infectionsTissue infectionsSpace infectionAcid-fast bacilliTreatment of skinNon-tuberculous mycobacteriaTerms of treatmentDisseminated diseaseOptimal regimenHand lesionsMedical managementExtremity lesionsCombination therapyInfectionLesionsAddition of rifampicinFurther dataSkinTreatmentMycobacteriaOsteomyelitisRegimenPatientsSurgeryCase Report: Disseminated Strongyloidiasis in a Patient with COVID-19
Lier AJ, Tuan JJ, Davis MW, Paulson N, McManus D, Campbell S, Peaper DR, Topal JE. Case Report: Disseminated Strongyloidiasis in a Patient with COVID-19. American Journal Of Tropical Medicine And Hygiene 2020, 103: 1590-1592. PMID: 32830642, PMCID: PMC7543803, DOI: 10.4269/ajtmh.20-0699.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAdrenal Cortex HormonesAgedAnimalsAnthelminticsAntibodies, Monoclonal, HumanizedBetacoronavirusCoinfectionConnecticutCoronavirus InfectionsCOVID-19Diabetes MellitusEcuadorHumansHypertensionImmunologic FactorsMalePandemicsPeripheral Nervous System DiseasesPneumonia, ViralSARS-CoV-2Strongyloides stercoralisStrongyloidiasis