Anti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions
Tinetti ME, Han L, McAvay GJ, Lee DS, Peduzzi P, Dodson JA, Gross CP, Zhou B, Lin H. Anti-Hypertensive Medications and Cardiovascular Events in Older Adults with Multiple Chronic Conditions. PLOS ONE 2014, 9: e90733. PMID: 24614535, PMCID: PMC3948696, DOI: 10.1371/journal.pone.0090733.Peer-Reviewed Original ResearchConceptsMultiple chronic conditionsAnti-hypertensive treatmentCardiovascular eventsAnti-hypertensive medicationsHigh-intensity groupChronic conditionsOlder adultsHazard ratioPropensity scoreIntensity groupStandardized daily doseCommunity-living participantsPropensity score adjustmentCV eventsMedication intensityLess comorbidityDaily doseRandomized trialsMAIN OUTCOMERepresentative cohortScore adjustmentSurvey cohortRCT resultsCohortMortalityContribution of Multiple Chronic Conditions to Universal Health Outcomes
Tinetti ME, McAvay GJ, Chang SS, Newman AB, Fitzpatrick AL, Fried TR, Peduzzi PN. Contribution of Multiple Chronic Conditions to Universal Health Outcomes. Journal Of The American Geriatrics Society 2011, 59: 1686-1691. PMID: 21883118, PMCID: PMC3622699, DOI: 10.1111/j.1532-5415.2011.03573.x.Peer-Reviewed Original ResearchConceptsChronic obstructive pulmonary diseaseUniversal health outcomesHeart failureSelf-rated healthCognitive impairmentHealth outcomesChronic conditionsObstructive pulmonary diseaseCardiovascular Health StudyCommunity-living participantsMultiple chronic conditionsPulmonary diseaseBurden ScaleInstrumental activitiesDaily livingCox modelHealth StudyCare prioritiesMore symptomsIADLsDepressionImpairmentOutcomesOsteoarthritisADLs