2021
The design and conduct of a randomized clinical trial comparing emergency department initiation of sublingual versus a 7-day extended-release injection formulation of buprenorphine for opioid use disorder: Project ED Innovation
D'Onofrio G, Hawk KF, Herring AA, Perrone J, Cowan E, McCormack RP, Dziura J, Taylor RA, Coupet E, Edelman EJ, Pantalon MV, Owens PH, Martel SH, O'Connor PG, Van Veldhuisen P, DeVogel N, Huntley K, Murphy SM, Lofwall MR, Walsh SL, Fiellin DA. The design and conduct of a randomized clinical trial comparing emergency department initiation of sublingual versus a 7-day extended-release injection formulation of buprenorphine for opioid use disorder: Project ED Innovation. Contemporary Clinical Trials 2021, 104: 106359. PMID: 33737199, PMCID: PMC9153252, DOI: 10.1016/j.cct.2021.106359.Peer-Reviewed Original ResearchMeSH KeywordsBuprenorphineDelayed-Action PreparationsEmergency Service, HospitalHumansNarcotic AntagonistsOpioid-Related DisordersConceptsOpioid use disorderRandomized clinical trialsPrimary outcomeFormal addiction treatmentOpioid withdrawalClinical trialsAncillary studiesUse disordersSelf-reported opioid useAddiction treatmentEmergency department initiationIncremental cost-effectiveness ratioReceipt of medicationEmergency department studyHealth service utilizationCost-effectiveness ratioOpioid useSecondary outcomesService utilizationTreatment accessEligibility criteriaImplementation facilitationBuprenorphineOverdose eventsDepartment study
1997
Sustained-release methylphenidate for cognitive impairment in HIV-1- infected drug abusers: a pilot study
van Dyck CH, McMahon TJ, Rosen MI, O'Malley SS, O'Connor PG, Lin CH, Pearsall HR, Woods SW, Kosten TR. Sustained-release methylphenidate for cognitive impairment in HIV-1- infected drug abusers: a pilot study. Journal Of Neuropsychiatry 1997, 9: 29-36. PMID: 9017526, DOI: 10.1176/jnp.9.1.29.Peer-Reviewed Original ResearchMeSH KeywordsAdultAttentionCentral Nervous System StimulantsCognition DisordersDelayed-Action PreparationsDouble-Blind MethodFemaleHIV InfectionsHIV-1HumansLearningMaleMemoryMethylphenidateMiddle AgedNeuropsychological TestsOpioid-Related DisordersPilot ProjectsPsychomotor PerformanceSubstance-Related DisordersConceptsSustained-release methylphenidateCognitive impairmentDouble-blind placebo-controlled crossover trialPlacebo-controlled crossover trialComposite neuropsychological measuresImpaired neuropsychological test performanceClinical improvementPlacebo treatmentCrossover trialMethadone patientsNeuropsychological test performancePlacebo performancePsychostimulant drugsDrug abusersPatientsStudy designPilot studySubstance abusersImpairmentNeuropsychological measuresMethylphenidateMore improvementAbusersTreatmentTest performance