2024
Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction.
Zhu C, Dreyer R, Li F, Spatz E, Caraballo C, Mahajan S, Raparelli V, Leifheit E, Lu Y, Krumholz H, Spertus J, D'Onofrio G, Pilote L, Lichtman J. Association of marital/partner status with hospital readmission among young adults with acute myocardial infarction. PLOS ONE 2024, 19: e0287949. PMID: 38277368, PMCID: PMC10817183, DOI: 10.1371/journal.pone.0287949.Peer-Reviewed Original ResearchConceptsMarital/partner statusPsychosocial factorsAcute myocardial infarctionYoung adultsHospital dischargeYear of hospital dischargeYoung acute myocardial infarctionAssociated with 1.3-foldCohort of young adultsLong-term readmissionCox proportional hazards modelsStatus interactionSimilar-aged menMyocardial infarctionProportional hazards modelUnpartnered statusPatient interviewsPhysician panelCardiovascular healthHospital readmissionSocioeconomic factorsAMI survivorsSequential adjustmentCardiac readmissionMultiple imputation
2023
Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients
Sawano M, Lu Y, Caraballo C, Mahajan S, Dreyer R, Lichtman J, D'Onofrio G, Spatz E, Khera R, Onuma O, Murugiah K, Spertus J, Krumholz H. Sex Difference in Outcomes of Acute Myocardial Infarction in Young Patients. Journal Of The American College Of Cardiology 2023, 81: 1797-1806. PMID: 37137590, DOI: 10.1016/j.jacc.2023.03.383.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionNoncardiac hospitalizationsSubdistribution HRYounger patientsMyocardial infarctionSex differencesYoung womenCause-specific hospitalizationsCause of hospitalizationWorse health statusSignificant sex disparityNoncardiovascular hospitalizationsVIRGO StudyIndex episodeAdverse outcomesIncidence rateHospitalizationHigh riskSex disparitiesHealth statusPatientsU.S. hospitalsWomenInfarctionOutcomesSex Differences in Symptom Complexity and Door-to-Balloon Time in Patients With ST-Elevation Myocardial Infarction
Brush J, Chaudhry S, Dreyer R, D'Onofrio G, Greene E, Hajduk A, Lu Y, Krumholz H. Sex Differences in Symptom Complexity and Door-to-Balloon Time in Patients With ST-Elevation Myocardial Infarction. The American Journal Of Cardiology 2023, 197: 101-107. PMID: 37062667, PMCID: PMC10198892, DOI: 10.1016/j.amjcard.2023.03.009.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionD2B timeSymptom complexityYoung womenChest painBalloon timeST-elevation myocardial infarctionSILVER-AMI StudySymptom phenotypeSex differencesPain symptomsCoronary interventionOlder patientsMyocardial infarctionOlder womenSTEMIOlder menSymptom patternsPresentation delayPatientsSymptom clustersLogistic regressionSymptomsWomenMean numberAssociation of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction
Okafor C, Zhu C, Raparelli V, Murphy T, Arakaki A, D’Onofrio G, Tsang S, Smith M, Lichtman J, Spertus J, Pilote L, Dreyer R. Association of Sociodemographic Characteristics With 1-Year Hospital Readmission Among Adults Aged 18 to 55 Years With Acute Myocardial Infarction. JAMA Network Open 2023, 6: e2255843. PMID: 36787140, PMCID: PMC9929697, DOI: 10.1001/jamanetworkopen.2022.55843.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionYoung adultsHospital readmissionBlack raceMyocardial infarctionRacial differencesCardiac factorsSociodemographic characteristicsBlack individualsOdds of readmissionObservational cohort studyMedical record abstractionRisk of readmissionWhite individualsAdults Aged 18Year of dischargePostdischarge readmissionVIRGO StudyCause readmissionCohort studyPrimary outcomeRecord abstractionMulticenter studyAged 18Male ratio
2022
Young Women With Acute Myocardial Infarction: Risk Prediction Model for 1-Year Hospital Readmission
Dreyer R, Arakaki A, Raparelli V, Murphy T, Tsang S, D’Onofrio G, Wood M, Wright C, Pilote L. Young Women With Acute Myocardial Infarction: Risk Prediction Model for 1-Year Hospital Readmission. CJC Open 2022, 5: 335-344. PMID: 37377522, PMCID: PMC10290947, DOI: 10.1016/j.cjco.2022.12.004.Peer-Reviewed Original ResearchAcute myocardial infarctionRisk prediction modelHospital readmissionYoung womenMyocardial infarctionYoung AMI Patients (VIRGO) studyObstructive coronary artery diseaseRisk of readmissionCongestive heart failureProspective observational studyCoronary artery diseaseYoung female patientHospital readmission riskHospital complicationsHospital stayYounger patientsArtery diseaseClinical factorsHeart failureFemale patientsReadmission riskObservational studyModest discriminationHigh riskDepressive symptomsSex Differences in Clopidogrel Effects Among Young Patients With Acute Coronary Syndrome: A Role for Genetics?
Kaur A, Dreyer R, Marsh T, Thanassoulis G, Raparelli V, D’Onofrio G, Engert J, Pilote L. Sex Differences in Clopidogrel Effects Among Young Patients With Acute Coronary Syndrome: A Role for Genetics? CJC Open 2022, 4: 970-978. PMID: 36444366, PMCID: PMC9700217, DOI: 10.1016/j.cjco.2022.07.013.Peer-Reviewed Original ResearchAcute coronary syndromeUsers of clopidogrelCoronary syndromeClinical outcomesMultivariable logistic regression modelSex differencesAdverse clinical outcomesWorse clinical outcomesTime of presentationGenetic risk scoreLogistic regression modelsSex-specific impactClopidogrel usersAtherothrombotic eventsCardiac eventsYounger patientsClopidogrel effectAntiplatelet agentsClopidogrelHigh riskRisk scoreIndependent factorsRole of sexHealth outcomesReadmission
2021
Development and Validation of a Risk Prediction Model for 1‐Year Readmission Among Young Adults Hospitalized for Acute Myocardial Infarction
Dreyer RP, Raparelli V, Tsang SW, D’Onofrio G, Lorenze N, Xie CF, Geda M, Pilote L, Murphy TE. Development and Validation of a Risk Prediction Model for 1‐Year Readmission Among Young Adults Hospitalized for Acute Myocardial Infarction. Journal Of The American Heart Association 2021, 10: e021047. PMID: 34514837, PMCID: PMC8649501, DOI: 10.1161/jaha.121.021047.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrior acute myocardial infarctionRisk prediction modelMyocardial infarctionYoung adultsDepressive symptomsLonger inpatient lengthPredictors of readmissionFinal risk modelYear of dischargeBetter physical healthAMI severityBackground ReadmissionHospital complicationsVIRGO StudyCause readmissionHospital lengthHospital dischargeYounger patientsDevelopment of interventionsDiabetes mellitusHeart failurePrimary outcomeConclusions WomenMean ageImpact of Race on the In‐Hospital Quality of Care Among Young Adults With Acute Myocardial Infarction
Raparelli V, Benea D, Smith M, Behlouli H, Murphy TE, D’Onofrio G, Pilote L, Dreyer RP. Impact of Race on the In‐Hospital Quality of Care Among Young Adults With Acute Myocardial Infarction. Journal Of The American Heart Association 2021, 10: e021408. PMID: 34431311, PMCID: PMC8649291, DOI: 10.1161/jaha.121.021408.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionCardiac readmissionMyocardial infarctionHospital qualitySocial determinantsYoung adultsWhite individualsBlack individualsSegment elevation myocardial infarctionCardiac risk factorsMultivariable logistic regressionHigh rateWhite US adultsVIRGO StudyBlack raceAMI careRisk factorsCare scoresHigh prevalenceUS adultsReadmissionLogistic regressionInfarctionImpact of raceRacial disparitiesROLE OF GENETICS IN SEX-SPECIFIC EFFECTS OF CLOPIDOGREL ON ATHEROTHROMBOTIC EVENTS
Kaur A, Dreyer R, Marsh T, Thanassoulis G, Raparelli V, D'Onofrio G, Engert J, Pilote L. ROLE OF GENETICS IN SEX-SPECIFIC EFFECTS OF CLOPIDOGREL ON ATHEROTHROMBOTIC EVENTS. Journal Of The American College Of Cardiology 2021, 77: 181. DOI: 10.1016/s0735-1097(21)01540-0.Peer-Reviewed Original Research
2020
The impact of sex, gender and healthcare system on quality of care among young adults with acute myocardial infarction
Raparelli V, Pilote L, Behlouli H, Dziura J, Bueno H, D'Onofrio G, Krumholz H, Dreyer R. The impact of sex, gender and healthcare system on quality of care among young adults with acute myocardial infarction. European Heart Journal 2020, 41: ehaa946.3175. DOI: 10.1093/ehjci/ehaa946.3175.Peer-Reviewed Original ResearchAcute myocardial infarctionQuality of careYoung adultsMyocardial infarctionHealthcare systemHigher risk factor burdenRisk factor burdenPost-discharge carePhases of careMultipayer systemImpact of sexSystem-level factorsHospital phaseAMI careCare scoresSingle-payer systemCareWomenCanadian InstituteSexAdultsMenInfarctionHospitalLinear regression models
2018
Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study
Safdar B, Spatz ES, Dreyer RP, Beltrame JF, Lichtman JH, Spertus JA, Reynolds HR, Geda M, Bueno H, Dziura JD, Krumholz HM, D'Onofrio G. Presentation, Clinical Profile, and Prognosis of Young Patients With Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): Results From the VIRGO Study. Journal Of The American Heart Association 2018, 7: e009174. PMID: 29954744, PMCID: PMC6064896, DOI: 10.1161/jaha.118.009174.Peer-Reviewed Original ResearchConceptsMI-CAD patientsNonobstructive coronary arteriesMI-CADYounger patientsClinical profileCoronary arteryMyocardial infarctionTraditional cardiac risk factorsAcute myocardial infarction patientsCardiac risk factorsGestational diabetes mellitusMyocardial infarction patientsTimes higher oddsMINOCA patientsSAQ qualityVIRGO StudyClinical characteristicsHypercoaguable stateDiabetes mellitusObstructive diseaseClinical outcomesInfarction patientsRisk factorsMINOCAPsychosocial status
2017
MECHANISMS OF ACUTE MYOCARDIAL INFARCTION IN YOUNG WOMEN AND DISCHARGE MEDICATION PATTERNS
Sciria C, Dreyer R, Safdar B, D'Onofrio G, Krumholz H, Spatz E. MECHANISMS OF ACUTE MYOCARDIAL INFARCTION IN YOUNG WOMEN AND DISCHARGE MEDICATION PATTERNS. Journal Of The American College Of Cardiology 2017, 69: 195. DOI: 10.1016/s0735-1097(17)33584-2.Peer-Reviewed Original ResearchPerceived Stress After Acute Myocardial Infarction
Xu X, Bao H, Strait KM, Edmondson DE, Davidson KW, Beltrame JF, Bueno H, Lin H, Dreyer RP, Brush JE, Spertus JA, Lichtman JH, D'Onofrio G, Krumholz HM. Perceived Stress After Acute Myocardial Infarction. Psychosomatic Medicine 2017, 79: 50-58. PMID: 27984507, PMCID: PMC5459399, DOI: 10.1097/psy.0000000000000429.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPSS-14 scoreMiddle-aged patientsPatient characteristicsMyocardial infarctionSex differencesMonths of recoveryAMI anginaInitial hospitalizationPerceived Stress ScalePatientsAnginaLess improvementLinear mixed-effects modelsFirst monthPsychological stressMixed-effects modelsWomenMonthsHigh levelsMenInfarctionStress ScalePerceived stress
2016
Editor’s Choice-Sex differences in young patients with acute myocardial infarction: A VIRGO study analysis
Bucholz EM, Strait KM, Dreyer RP, Lindau ST, D’Onofrio G, Geda M, Spatz ES, Beltrame JF, Lichtman JH, Lorenze NP, Bueno H, Krumholz HM. Editor’s Choice-Sex differences in young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2016, 6: 610-622. PMID: 27485141, PMCID: PMC5459677, DOI: 10.1177/2048872616661847.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionYoung womenTime of AMIST-segment elevation myocardial infarctionHigh clinical risk scoreSegment elevation myocardial infarctionChronic obstructive pulmonary diseaseYoung AMI patientsCardiovascular risk factorsClinical risk scorePre-hospital delayProspective cohort studyCongestive heart failureElevation myocardial infarctionObstructive pulmonary diseaseHigh-risk populationYoung menMental health statusElectrocardiogram findingsMorbid obesityCardiovascular riskCohort studyRenal failureYounger patients
2015
Sex Differences in Reperfusion in Young Patients With ST-Segment–Elevation Myocardial Infarction
D'Onofrio G, Safdar B, Lichtman JH, Strait KM, Dreyer RP, Geda M, Spertus JA, Krumholz HM. Sex Differences in Reperfusion in Young Patients With ST-Segment–Elevation Myocardial Infarction. Circulation 2015, 131: 1324-1332. PMID: 25792558, PMCID: PMC4652789, DOI: 10.1161/circulationaha.114.012293.Peer-Reviewed Original ResearchConceptsST-segment elevation myocardial infarctionMyocardial infarctionReperfusion therapyAcute ST-segment elevation myocardial infarctionProspective observational cohort studyYoung AMI Patients (VIRGO) studyTime guidelinesYoung womenObservational cohort studyProportion of patientsElevation myocardial infarctionPercutaneous coronary interventionYears of ageSex differencesPatients 18Reperfusion strategyCohort studyCoronary interventionFibrinolytic therapyNeedle timeYounger patientsReperfusion delayRatio of womenReperfusion guidelinesSex disparitiesSEX DIFFERENCES IN 12-MONTH HEALTH STATUS IN YOUNG PATIENTS FOLLOWING ACUTE MYOCARDIAL INFARCTION: RESULTS FROM THE VIRGO STUDY (VARIATION IN RECOVERY: ROLE OF GENDER ON OUTCOMES OF YOUNG ACUTE MYOCARDIAL INFARCTION PATIENTS)
Dreyer R, Wang Y, Strait K, Lorenze N, D’Onofrio G, Bueno H, Lichtman J, Spertus J, Krumholz H. SEX DIFFERENCES IN 12-MONTH HEALTH STATUS IN YOUNG PATIENTS FOLLOWING ACUTE MYOCARDIAL INFARCTION: RESULTS FROM THE VIRGO STUDY (VARIATION IN RECOVERY: ROLE OF GENDER ON OUTCOMES OF YOUNG ACUTE MYOCARDIAL INFARCTION PATIENTS). Journal Of The American College Of Cardiology 2015, 65: a6. DOI: 10.1016/s0735-1097(15)60006-7.Peer-Reviewed Original ResearchGender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis
Dreyer RP, Smolderen KG, Strait KM, Beltrame JF, Lichtman JH, Lorenze NP, D’Onofrio G, Bueno H, Krumholz HM, Spertus JA. Gender differences in pre-event health status of young patients with acute myocardial infarction: A VIRGO study analysis. European Heart Journal Acute Cardiovascular Care 2015, 5: 43-54. PMID: 25681487, PMCID: PMC4658311, DOI: 10.1177/2048872615568967.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionPrior coronary artery diseaseCoronary artery diseaseHealth statusMyocardial infarctionYounger patientsArtery diseaseCoronary artery disease historyDisease-specific health statusAcute myocardial infarction patientsAggressive symptom controlCornerstone of careWorse physical functionBaseline health statusMedical record abstractionVisual analog scaleHealth status outcomesMyocardial infarction patientsDisease-specific measuresMean health scoresLogistic regression analysisQuality of lifeHealth status informationGender differencesSymptom control