2005
Glutathione protects human airway proteins and epithelial cells from isocyanates
Wisnewski AV, Liu Q, Liu J, Redlich CA. Glutathione protects human airway proteins and epithelial cells from isocyanates. Clinical & Experimental Allergy 2005, 35: 352-357. PMID: 15784115, DOI: 10.1111/j.1365-2222.2005.02185.x.Peer-Reviewed Original ResearchConceptsDose-dependent mannerAirway fluidGSH levelsHuman airway epithelial cellsVapor exposure systemEpithelial cellsHuman airway epithelial cell lineAirway epithelial cell lineEpithelial lining fluidAirway epithelial cellsEpithelial cell exposureEpithelial cell toxicityAllergic sensitizationEpithelial cell lineHDI exposureAirway proteinsLining fluidAirway cellsIsocyanate exposureVivo exposureOccupational limitsNCI-H292Physiologic levelsEpithelial fluidToxicity studies
2003
Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanate
Wisnewski AV, Herrick CA, Liu Q, Chen L, Bottomly K, Redlich CA. Human γ/δ T-cell proliferation and IFN-γ production induced by hexamethylene diisocyanate. Journal Of Allergy And Clinical Immunology 2003, 112: 538-546. PMID: 13679813, DOI: 10.1016/s0091-6749(03)01865-7.Peer-Reviewed Original ResearchConceptsGamma/delta T cellsDelta T cellsHuman immune responseT cellsT cell receptorImmune responseAlpha/beta T cell receptorBeta T cell receptorHuman airway epithelial cellsIFN-γ productionGamma/deltaT cell proliferationAirway epithelial cellsHuman T cell lineT cell linesHuman T cellsCell typesOccupational asthmaCytokine productionPeripheral bloodIL-13IL-5Antigen-mediated selectionAntigen leadIFN-gamma
2001
Human γ / δ T-Cell Lines Derived from Airway Biopsies
Wisnewski A, Cain H, Magoski N, Wang H, Holm C, Redlich C. Human γ / δ T-Cell Lines Derived from Airway Biopsies. American Journal Of Respiratory Cell And Molecular Biology 2001, 24: 332-338. PMID: 11245633, DOI: 10.1165/ajrcmb.24.3.4325.Peer-Reviewed Original ResearchConceptsGamma/delta T cellsDelta T cellsT cell linesT cell receptorT cellsTetanus toxoidAirway biopsiesPeripheral bloodGamma/delta T cell linesGamma/delta T cell receptorBlood-derived T cellsDelta T-cell receptorDifferent T cell receptorsAirway T cellsLike cytokine profileAntigen-dependent proliferationT helper 1Human airway tissuePeripheral blood samplesHuman lung tissueHuman airway biopsiesCytokine profileAirway tissueHelper 1Lung tissue
1996
IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury.
Redlich C, Gao X, Rockwell S, Kelley M, Elias J. IL-11 enhances survival and decreases TNF production after radiation-induced thoracic injury. The Journal Of Immunology 1996, 157: 1705-10. PMID: 8759759, DOI: 10.4049/jimmunol.157.4.1705.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBronchoalveolar Lavage FluidCell LineGene Expression RegulationGene Expression Regulation, NeoplasticInjections, SubcutaneousInterleukin-11Lung NeoplasmsMacrophages, AlveolarMiceMice, Inbred BALB CNeoplasm ProteinsNeoplastic Stem CellsRadiation Injuries, ExperimentalRecombinant ProteinsRNA, MessengerRNA, NeoplasmSpecific Pathogen-Free OrganismsThoracic InjuriesTumor Necrosis Factor-alphaConceptsThoracic irradiationThoracic injuriesControl miceTNF protein productionTNF productionVehicle-treated control miceNormal thoracic structuresPulmonary metastatic tumorsEMT6 tumor cellsTNF mRNA expressionDose of radiationLung metastasesInhibits LPSMetastatic tumorsNormal lungRadioprotective effectMRNA expressionIL-11Enhances SurvivalTumor cellsObserved protectionSignificant radioprotectionTNF mRNAThoracic structuresStudy interval
1995
Retinoic acid inhibition of transforming growth factor-beta-induced collagen production by human lung fibroblasts.
Redlich C, Delisser H, Elias J. Retinoic acid inhibition of transforming growth factor-beta-induced collagen production by human lung fibroblasts. American Journal Of Respiratory Cell And Molecular Biology 1995, 12: 287-295. PMID: 7873195, DOI: 10.1165/ajrcmb.12.3.7873195.Peer-Reviewed Original ResearchConceptsHuman lung fibroblastsRetinoic acidCollagen productionChronic inflammatory lung disordersDoses of RALung fibroblastsType IInhibitory effectInflammatory lung disordersTrans retinoic acidFibroblast collagen productionM retinoic acidLung disordersPotent immunomodulatorFibrotic responseRetinoid compoundsType III collagenBasal levelsSignificant inhibitionAcid inhibitionSignificant decreaseRetinoidsUnstimulated cellsPreincubationStimulation