2022
Soluble CD14-associated DNA methylation sites predict mortality among men with HIV infection
Titanji BK, Wang Z, Chen J, Hui Q, So-Armah K, Freiberg M, Justice AC, Ke X, Marconi VC, Sun YV. Soluble CD14-associated DNA methylation sites predict mortality among men with HIV infection. AIDS 2022, 36: 1563-1571. PMID: 35979830, PMCID: PMC9394925, DOI: 10.1097/qad.0000000000003279.Peer-Reviewed Original ResearchMeSH KeywordsCohort StudiesDNA MethylationEpigenesis, GeneticGenome-Wide Association StudyHIV InfectionsHumansInflammationLipopolysaccharide ReceptorsMaleConceptsVeterans Aging Cohort StudyAging Cohort StudyElevated plasma levelsCox regression modelUnderstanding of prognosisPeripheral blood samplesPotential therapeutic targetEpigenome-wide association studiesMultiple testingCause mortalitySCD14 levelsCohort studyHIV infectionPlasma levelsSoluble CD14Disease progressionImmune functionSurvival timeBlood samplesSCD14Therapeutic targetPWHAntiviral responseSignificant associationDNAm sites
2017
HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer
Taylor BS, So-Armah K, Tate JP, Marconi VC, Koethe JR, Bedimo RJ, Butt AA, Gibert CL, Goetz MB, Rodriguez-Barradas MC, Womack JA, Gerschenson M, Lo Re V, Rimland D, Yin MT, Leaf D, Tracy RP, Justice AC, Freiberg MS. HIV and Obesity Comorbidity Increase Interleukin 6 but Not Soluble CD14 or D-Dimer. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2017, 75: 500-508. PMID: 28696344, PMCID: PMC5513170, DOI: 10.1097/qai.0000000000001444.Peer-Reviewed Original ResearchConceptsIL-6Nonobese/Obese/D-dimerMedian IL-6 levelHIV status groupsElevated IL-6D-dimer levelsIL-6 levelsBody mass indexLogistic regression modelsElevated sCD14Uninfected participantsSCD14 levelsHIV infectionProinflammatory stateHIV statusInflammation increasesMass indexObesity/Soluble CD14Interleukin-6Obesity prevalenceOdds ratioInclusion criteria
2016
Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People?
So-Armah KA, Tate JP, Chang CH, Butt AA, Gerschenson M, Gibert CL, Leaf D, Rimland D, Rodriguez-Barradas MC, Budoff MJ, Samet JH, Kuller LH, Deeks SG, Crothers K, Tracy RP, Crane HM, Sajadi MM, Tindle HA, Justice AC, Freiberg MS. Do Biomarkers of Inflammation, Monocyte Activation, and Altered Coagulation Explain Excess Mortality Between HIV Infected and Uninfected People? JAIDS Journal Of Acquired Immune Deficiency Syndromes 2016, 72: 206-213. PMID: 27824677, PMCID: PMC4867134, DOI: 10.1097/qai.0000000000000954.Peer-Reviewed Original ResearchConceptsBiomarkers of inflammationD-dimerIL-6Uninfected peopleMortality riskHIV infectionMonocyte activationVeterans Aging Cohort Study Biomarker CohortCox proportional hazards regressionElevated IL-6Excess mortality riskProportional hazards regressionUnsuppressed viremiaComorbid diseasesBiomarker cohortHighest quartileHIV statusHazards regressionExcess riskBlood drawExcess mortalityImmunologic processesSCD14Mortality rateLogistic regression
2014
Increased Risk of Radiographic Emphysema in HIV Is Associated With Elevated Soluble CD14 and Nadir CD4
Attia EF, Akgün KM, Wongtrakool C, Goetz MB, Rodriguez-Barradas MC, Rimland D, Brown ST, Hoo G, Kim J, Lee PJ, Schnapp LM, Sharafkhaneh A, Justice AC, Crothers K. Increased Risk of Radiographic Emphysema in HIV Is Associated With Elevated Soluble CD14 and Nadir CD4. CHEST Journal 2014, 146: 1543-1553. PMID: 25080158, PMCID: PMC4251616, DOI: 10.1378/chest.14-0543.Peer-Reviewed Original ResearchMeSH KeywordsAdultAge FactorsBiomarkersCD4 AntigensComorbidityConfidence IntervalsCross-Sectional StudiesFemaleHIV InfectionsHumansLipopolysaccharide ReceptorsLogistic ModelsMaleMiddle AgedMultivariate AnalysisOdds RatioPrognosisPulmonary EmphysemaRadiographyReference ValuesRisk AssessmentSensitivity and SpecificitySeverity of Illness IndexSex FactorsStatistics, NonparametricConceptsIndependent risk factorSoluble CD14 levelsHIV infectionRadiographic emphysemaEmphysema severityCD14 levelsRisk factorsHIV-Associated Lung Emphysema (EXHALE) studyHigher soluble CD14 levelsNadir CD4 cell countMultivariable logistic regression modelElevated soluble CD14CD4 cell countCells/μLLower lung zonesRisk of HIVCross-sectional analysisLogistic regression modelsNadir CD4HIV RNALung involvementHIV severityD-dimerDiffuse involvementMultivariable analysis
2012
HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation
Armah KA, McGinnis K, Baker J, Gibert C, Butt AA, Bryant KJ, Goetz M, Tracy R, Oursler KK, Rimland D, Crothers K, Rodriguez-Barradas M, Crystal S, Gordon A, Kraemer K, Brown S, Gerschenson M, Leaf DA, Deeks SG, Rinaldo C, Kuller LH, Justice A, Freiberg M. HIV Status, Burden of Comorbid Disease, and Biomarkers of Inflammation, Altered Coagulation, and Monocyte Activation. Clinical Infectious Diseases 2012, 55: 126-136. PMID: 22534147, PMCID: PMC3493182, DOI: 10.1093/cid/cis406.Peer-Reviewed Original ResearchConceptsBiomarkers of inflammationVeterans Aging Cohort StudyAltered coagulationMonocyte activationUninfected veteransCardiovascular diseaseElevated biomarkersComorbid conditionsHigh prevalenceCD4 cell countElevated IL-6Aging Cohort StudyOngoing HIV replicationPrevalent cardiovascular diseaseHIV-1 RNAHuman immunodeficiency virusCopies/mLElevated sCD14More dyslipidemiaCD4 countHepatitis CCohort studyComorbid diseasesCurrent smokingHIV infectionDoes an Index Composed of Clinical Data Reflect Effects of Inflammation, Coagulation, and Monocyte Activation on Mortality Among Those Aging With HIV?
Justice AC, Freiberg MS, Tracy R, Kuller L, Tate JP, Goetz MB, Fiellin DA, Vanasse GJ, Butt AA, Rodriguez-Barradas MC, Gibert C, Oursler KA, Deeks SG, Bryant K, Team T. Does an Index Composed of Clinical Data Reflect Effects of Inflammation, Coagulation, and Monocyte Activation on Mortality Among Those Aging With HIV? Clinical Infectious Diseases 2012, 54: 984-994. PMID: 22337823, PMCID: PMC3297653, DOI: 10.1093/cid/cir989.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAgingBiomarkersFemaleFibrin Fibrinogen Degradation ProductsHIV InfectionsHIV-1HumansInterleukin-6Lipopolysaccharide ReceptorsMaleMiddle AgedPrognosisSurvival AnalysisConceptsHIV-1 RNANet reclassification improvementHepatitis C virusD-dimerIL-6VACS IndexMonocyte activationVeterans Aging Cohort Study (VACS) IndexHuman immunodeficiency virus type 1 (HIV-1) RNAFIB-4 indexGlomerular filtration rateMarkers of liverRoutine clinical variablesCopies/mLPrediction of mortalityEffects of inflammationHCV statusAntiretroviral therapyCD4 countRenal injuryReclassification improvementClinical variablesC-statisticC virusFiltration rate