2020
Frequency and Duration of Incarceration and Mortality Among US Veterans With and Without HIV.
Hawks LC, McGinnis KA, Howell BA, Khan MR, Edelman EJ, Justice AC, Wang EA. Frequency and Duration of Incarceration and Mortality Among US Veterans With and Without HIV. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2020, 84: 220-227. PMID: 32049771, PMCID: PMC7228828, DOI: 10.1097/qai.0000000000002325.Peer-Reviewed Original ResearchConceptsRisk of mortalityAdjusted hazard ratioCohort studyHIV statusVeterans Aging Cohort StudyCox proportional hazards modelTransitional health careProspective cohort studyAging Cohort StudyConfidence intervalsProportional hazards modelDose-response fashionFrequency of incarcerationDuration of incarcerationIncarceration exposureHIV careHazard ratioPrimary exposureUS veteransLeading causeHigh riskIncrease riskHazards modelCumulative durationPWH
2018
Duration of opioid prescriptions predicts incident nonmedical use of prescription opioids among U.S. veterans receiving medical care
Barry DT, Marshall BDL, Becker WC, Gordon AJ, Crystal S, Kerns RD, Gaither JR, Gordon KS, Justice AC, Fiellin DA, Edelman EJ. Duration of opioid prescriptions predicts incident nonmedical use of prescription opioids among U.S. veterans receiving medical care. Drug And Alcohol Dependence 2018, 191: 348-354. PMID: 30176548, PMCID: PMC6596307, DOI: 10.1016/j.drugalcdep.2018.07.008.Peer-Reviewed Original ResearchConceptsPrescription opioid receiptPrescription opioidsMedical careOpioid receiptVeterans Health Administration primary careNonmedical useMultivariable Cox modelInfectious disease clinicProspective cohort studyProportional hazards regressionPrescription opioid medicationsPublic health problemSubstance use disordersMedication-related characteristicsOpioid therapyOpioid medicationsOpioid prescriptionsCohort studyDisease clinicMedian ageHazards regressionEligible participantsPrimary careRisk factorsIncidence rateAssociation of Viral Suppression With Lower AIDS-Defining and Non-AIDS-Defining Cancer Incidence in HIV-Infected Veterans: A Prospective Cohort Study.
Park LS, Tate JP, Sigel K, Brown ST, Crothers K, Gibert C, Goetz MB, Rimland D, Rodriguez-Barradas MC, Bedimo RJ, Justice AC, Dubrow R. Association of Viral Suppression With Lower AIDS-Defining and Non-AIDS-Defining Cancer Incidence in HIV-Infected Veterans: A Prospective Cohort Study. Annals Of Internal Medicine 2018, 169: 87-96. PMID: 29893768, PMCID: PMC6825799, DOI: 10.7326/m16-2094.Peer-Reviewed Original ResearchConceptsLong-term viral suppressionViral suppressionLong-term suppressionCancer incidenceCancer riskHIV treatment successLow viral suppressionViral suppression statusProspective cohort studyT-cell countsEffect of CD4HIV-positive veteransCancer incidence ratesNational InstituteNational Cancer InstituteAIDS definingNon-AIDSUninfected veteransAntiretroviral therapyExcess cancer riskProspective cohortCohort studyUninfected personsIncidence rateTreatment successBilirubin Is Inversely Associated With Cardiovascular Disease Among HIV‐Positive and HIV‐Negative Individuals in VACS (Veterans Aging Cohort Study)
Marconi VC, Duncan MS, So‐Armah K, Re VL, Lim JK, Butt AA, Goetz MB, Rodriguez‐Barradas M, Alcorn CW, Lennox J, Beckman JA, Justice A, Freiberg M. Bilirubin Is Inversely Associated With Cardiovascular Disease Among HIV‐Positive and HIV‐Negative Individuals in VACS (Veterans Aging Cohort Study). Journal Of The American Heart Association 2018, 7: e007792. PMID: 29720501, PMCID: PMC6015337, DOI: 10.1161/jaha.117.007792.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionTotal cardiovascular diseaseIschemic stroke eventsCardiovascular diseaseCVD eventsHeart failureMyocardial infarctionTotal bilirubinElevated bilirubinStroke eventsRisk factorsIncident total CVDBaseline total bilirubinBaseline cardiovascular diseaseIncident CVD eventsHIV-negative individualsProspective cohort studyElevated bilirubin levelsMultiple risk factorsCohort studyCVD riskHazard ratioIschemic strokeHIV-positiveBilirubin levelsCommonly Prescribed Antiretroviral Therapy Regimens and Incidence of AIDS-Defining Neurological Conditions
Caniglia EC, Phillips A, Porter K, Sabin CA, Winston A, Logan R, Gill J, Vandenhende MA, Barger D, Lodi S, Moreno S, Arribas JR, Pacheco A, Cardoso SW, Chrysos G, Gogos C, Abgrall S, Costagliola D, Meyer L, Seng R, van Sighem A, Reiss P, Muga R, Hoyos SP, Braun D, Hauser C, Barrufet P, Leyes M, Tate J, Justice A, Hernán MA. Commonly Prescribed Antiretroviral Therapy Regimens and Incidence of AIDS-Defining Neurological Conditions. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2018, 77: 102-109. PMID: 28991888, PMCID: PMC5720915, DOI: 10.1097/qai.0000000000001562.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAIDS Dementia ComplexAIDS-Related Opportunistic InfectionsAlkynesAmericasAtazanavir SulfateBenzoxazinesCohort StudiesCyclopropanesDarunavirEuropeFemaleHIV Protease InhibitorsHumansLeukoencephalopathy, Progressive MultifocalLopinavirMaleMeningitis, CryptococcalMiddle AgedProspective StudiesReverse Transcriptase InhibitorsToxoplasmosisConceptsNucleoside reverse transcriptase inhibitor (NRTI) backboneReverse transcriptase inhibitor backboneHazard ratioNeurological conditionsInhibitor backbonePooled logistic modelCombined end pointRespective hazard ratiosProgressive multifocal leukoencephalopathyProspective cohort studyAntiretroviral therapy regimensHIV-positive individualsHIV-CAUSAL CollaborationIncidence of AIDSCART initiationHIV dementiaAntiretroviral therapyCART regimenCryptococcal meningitisMultifocal leukoencephalopathyClinical characteristicsCohort studyTherapy regimensAtazanavirLopinavir
2016
Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era
Park LS, Tate JP, Sigel K, Rimland D, Crothers K, Gibert C, Rodriguez-Barradas MC, Goetz MB, Bedimo RJ, Brown ST, Justice AC, Dubrow R. Time trends in cancer incidence in persons living with HIV/AIDS in the antiretroviral therapy era. AIDS 2016, 30: 1795-1806. PMID: 27064994, PMCID: PMC4925286, DOI: 10.1097/qad.0000000000001112.Peer-Reviewed Original ResearchConceptsAntiretroviral therapy eraIncidence rateUninfected personsTherapy eraCohort studyCancer incidenceVeterans Aging Cohort StudyImproved immune functionLarge HIV cohortProspective cohort studyCrude incidence rateIncident cancer diagnosisRisk factor prevalenceAging Cohort StudyEvidence-based screeningIncidence rate ratiosIncidence time trendsFuture cancer incidenceTime trendsHIV/AIDSTrend P valueCancer groupingsSpecific cancer typesART regimensHIV care
2010
Virologic and immunologic response to HAART, by age and regimen class
Althoff KN, Justice AC, Gange SJ, Deeks SG, Saag MS, Silverberg MJ, Gill MJ, Lau B, Napravnik S, Tedaldi E, Klein MB, Gebo KA. Virologic and immunologic response to HAART, by age and regimen class. AIDS 2010, 24: 2469-2479. PMID: 20829678, PMCID: PMC3136814, DOI: 10.1097/qad.0b013e32833e6d14.Peer-Reviewed Original ResearchConceptsCD4 cell countImmunologic responseNorth American AIDS Cohort CollaborationCell countMean CD4 cell countProtease inhibitor-based regimenNonnucleoside reverse transcriptase inhibitorAntiretroviral-naive adultsInhibitor-based regimenInitial antiretroviral regimenProspective cohort studyConfidence intervalsReverse transcriptase inhibitorImpact of ageInverse probability weightsCohort CollaborationInitial regimenAntiretroviral regimenVirologic responseCohort studyViral loadEligible participantsOdds ratioTranscriptase inhibitorRegimen
2009
Mortality of HIV-infected patients starting potent antiretroviral therapy: comparison with the general population in nine industrialized countries
Zwahlen M, Harris R, May M, Hogg R, Costagliola D, de Wolf F, Gill J, Fätkenheuer G, Lewden C, Saag M, Staszewski S, d'Arminio Monforte A, Casabona J, Lampe F, Justice A, von Wyl V, Egger M. Mortality of HIV-infected patients starting potent antiretroviral therapy: comparison with the general population in nine industrialized countries. International Journal Of Epidemiology 2009, 38: 1624-1633. PMID: 19820106, PMCID: PMC3119390, DOI: 10.1093/ije/dyp306.Peer-Reviewed Original ResearchMeSH KeywordsAcquired Immunodeficiency SyndromeAdultAnti-Retroviral AgentsAntiretroviral Therapy, Highly ActiveCause of DeathCD4 Lymphocyte CountCohort StudiesFemaleHIVHIV InfectionsHomosexuality, MaleHumansMaleMortalityPrevalenceProspective StudiesRisk FactorsSubstance Abuse, IntravenousViral LoadVirus ReplicationConceptsCD4 cell countAntiretroviral therapyCells/microLGeneral populationCell countEligible patientsExcess mortalityCopies/Start of ARTViral replicationART Cohort CollaborationCorresponding general populationMortality of HIVPotent antiretroviral therapyCombination antiretroviral therapyPercentage of patientsProspective cohort studyInjection drug useViral load measurementsNumber of deathsCohort CollaborationCohort studyMedian ageViral loadClinical stageTiming of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies
Sterne J, May M, Costagliola D, de Wolf F, Phillips A, Harris R, Funk M, Geskus R, Gill J, Dabis F, Miró J, Justice A, Ledergerber B, Fätkenheuer G, Hogg R, Monforte A, Saag M, Smith C, Staszewski S, Egger M, Cole S. Timing of initiation of antiretroviral therapy in AIDS-free HIV-1-infected patients: a collaborative analysis of 18 HIV cohort studies. The Lancet 2009, 373: 1352-1363. PMID: 19361855, PMCID: PMC2670965, DOI: 10.1016/s0140-6736(09)60612-7.Peer-Reviewed Original ResearchMeSH KeywordsAdultAntiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCohort StudiesDisease ProgressionDrug Administration ScheduleEuropeFemaleHIV InfectionsHIV-1HumansKaplan-Meier EstimateMaleMiddle AgedNorth AmericaPatient SelectionPractice Guidelines as TopicProportional Hazards ModelsSensitivity and SpecificityTime FactorsTreatment OutcomeConceptsHIV-1-infected patientsCombination antiretroviral therapyCD4 cell countAntiretroviral therapyCombination therapyCohort studyCell countCD4 cell count rangeCD4 cell count thresholdAntiretroviral-naive patientsProspective cohort studyHIV Cohort StudyRates of AIDSStart of treatmentHigh mortality rateAbsence of treatmentTiming of initiationDeath eventsCell count thresholdTherapy groupImmediate initiationPatientsMortality rateTherapyAIDS
2008
Prognostic Importance of Anaemia in HIV Type-1-Infected Patients Starting Antiretroviral Therapy: Collaborative Analysis of Prospective Cohort Studies
Harris RJ, Sterne J, Abgrall S, Dabis F, Reiss P, Saag M, Phillips AN, Chêne G, Gill JM, Justice AC, Rockstroh J, Sabin CA, Mocroft A, Bucher HC, Hogg RS, Monforte AD, May M, Egger M. Prognostic Importance of Anaemia in HIV Type-1-Infected Patients Starting Antiretroviral Therapy: Collaborative Analysis of Prospective Cohort Studies. Antiviral Therapy 2008, 13: 959-967. PMID: 19195321, PMCID: PMC4507810, DOI: 10.1177/135965350801300802.Peer-Reviewed Original ResearchConceptsHIV type-1-infected patientsMild anemiaAntiretroviral therapyHemoglobin levelsAdjusted hazard ratioMonths of HAARTStart of HAARTActive antiretroviral therapyT-cell countsPrevalence of anemiaProspective cohort studyLong-term prognosisBaseline anemiaAIDS eventsHazard ratioCohort studyPrognostic importancePrognostic valueProspective studyUntreated individualsPatientsAnemiaHigh mortalityHAARTNormal hemoglobin
2003
How Harmful Is Hazardous Alcohol Use and Abuse in HIV Infection: Do Health Care Providers Know Who Is at Risk?
Conigliaro J, Gordon AJ, McGinnis KA, Rabeneck L, Justice AC. How Harmful Is Hazardous Alcohol Use and Abuse in HIV Infection: Do Health Care Providers Know Who Is at Risk? JAIDS Journal Of Acquired Immune Deficiency Syndromes 2003, 33: 521-525. PMID: 12869842, DOI: 10.1097/00126334-200308010-00014.Peer-Reviewed Original ResearchConceptsHealth care providersHIV disease progressionCare providersAlcohol diagnosisDisease progressionTransaminase levelsHIV infectionViral loadAlcohol useBinge drinkersHazardous drinkingHealth care providers' awarenessElevated mean corpuscular volumeSevere HIV infectionCD4 cell countPercent of patientsUndetectable viral loadAspartate transaminase levelsDetectable viral loadProspective cohort studyAlcohol Use Disorders Identification TestCare providers' awarenessHIV-positive veteransAlcohol problemsExcessive alcohol use
1999
The Relationship Between Clinical Assessments of Nutritional Status and Adverse Outcomes in Older Hospitalized Medical Patients
Covinsky K, Martin G, Beyth R, Justice A, Sehgal A, Landefeld C. The Relationship Between Clinical Assessments of Nutritional Status and Adverse Outcomes in Older Hospitalized Medical Patients. Journal Of The American Geriatrics Society 1999, 47: 532-538. PMID: 10323645, DOI: 10.1111/j.1532-5415.1999.tb02566.x.Peer-Reviewed Original ResearchConceptsNursing home useAcute illness severityAdverse outcomesIllness severityNutritional statusClinical assessmentMalnourished patientsHospital admissionSubjective Global AssessmentProspective cohort studyTertiary care hospitalHome useIndex of comorbidityGeneral medical servicesPhysical exam findingsHospitalized older peopleYear of dischargeLogistic regression modelsNourished patientsSurrogate interviewsHospital outcomesChart reviewCohort studyCare hospitalHospitalized patients
1998
The Relation Between Health Status Changes and Patient Satisfaction in Older Hospitalized Medical Patients
Covinsky K, Rosenthal G, Chren M, Justice A, Fortinsky R, Palmer R, Landefeld C. The Relation Between Health Status Changes and Patient Satisfaction in Older Hospitalized Medical Patients. Journal Of General Internal Medicine 1998, 13: 223-229. PMID: 9565384, PMCID: PMC1496938, DOI: 10.1046/j.1525-1497.1998.00071.x.Peer-Reviewed Original ResearchConceptsPatient satisfactionMean satisfaction scoreHealth statusMedical patientsHospital careSatisfaction scoresProspective cohort studyOlder medical patientsPatient satisfaction questionnairePatient outcome measuresTendency of patientsGlobal healthHealth status changesHospital outcomesCohort studyGreater satisfactionStable healthHealthy patientsTeaching hospitalOutcome measuresDaily livingPatientsAdmissionMultivariate analysisSimilar satisfaction