2022
Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies
Farokhnia M, Rentsch CT, Chuong V, McGinn MA, Elvig SK, Douglass EA, Gonzalez LA, Sanfilippo JE, Marchette RCN, Tunstall BJ, Fiellin DA, Koob GF, Justice AC, Leggio L, Vendruscolo LF. Spironolactone as a potential new pharmacotherapy for alcohol use disorder: convergent evidence from rodent and human studies. Molecular Psychiatry 2022, 27: 4642-4652. PMID: 36123420, PMCID: PMC10231646, DOI: 10.1038/s41380-022-01736-y.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAlcohol Use Disorders Identification Test-ConsumptionEffect of spironolactoneAlcohol consumptionSpironolactone doseNovel pharmacotherapiesUse disordersHuman studiesLarge integrated healthcare systemHeavy episodic alcohol consumptionAlcohol-induced ataxiaMineralocorticoid receptor antagonistsSelf-reported alcohol consumptionBlood alcohol levelsEpisodic alcohol consumptionIntegrated healthcare systemPharmacoepidemiologic cohort studyPotential new pharmacotherapiesCohort studyAlcohol drinkingReceptor antagonistFemale miceFemale ratsNew pharmacotherapiesRat model
2020
Association of Alcohol Screening Scores With Adverse Mental Health Conditions and Substance Use Among US Adults
Khan MR, Young KE, Caniglia EC, Fiellin DA, Maisto SA, Marshall BDL, Edelman EJ, Gaither JR, Chichetto NE, Tate J, Bryant KJ, Severe M, Stevens ER, Justice A, Braithwaite SR. Association of Alcohol Screening Scores With Adverse Mental Health Conditions and Substance Use Among US Adults. JAMA Network Open 2020, 3: e200895. PMID: 32163167, PMCID: PMC7068229, DOI: 10.1001/jamanetworkopen.2020.0895.Peer-Reviewed Original ResearchConceptsAlcohol Use Disorders Identification TestAlcohol Use Disorders Identification Test-ConsumptionAUDIT-C scoresUse of tobaccoAlcohol screeningCohort studyInjection drugsCocaine useVeterans Aging Cohort StudyVeterans Health Administration facilitiesStimulant useAlcohol useAUDIT scoresAging Cohort StudyLongitudinal cohort studyVeterans Health AdministrationAdverse mental health conditionsSite of careFull Alcohol Use Disorders Identification TestMental health conditionsAlcohol Screening ScoresSelf-reported symptomsSymptoms of depressionDisorders Identification TestUse screening tools
2019
Longitudinal Drinking Patterns and Their Clinical Correlates in Million Veteran Program Participants
Smith R, Kranzler HR, Justice AC, Tate JP, Program T. Longitudinal Drinking Patterns and Their Clinical Correlates in Million Veteran Program Participants. Alcohol Clinical And Experimental Research 2019, 43: 465-472. PMID: 30592535, PMCID: PMC6691890, DOI: 10.1111/acer.13951.Peer-Reviewed Original ResearchConceptsMean AUDIT-C scoreAUDIT-C scoresAlcohol Use Disorders Identification Test-ConsumptionTrajectory groupsU.S. Preventive Services Task ForceDrinking trajectoriesAge-adjusted mean scoresVeterans Affairs Health SystemPrimary care patientsLarger patient populationMillion Veteran Program cohortAlcohol use disorder diagnosisHigh trajectory groupPosttraumatic stress disorderElectronic health recordsHepatitis CCare patientsLiver cirrhosisClinical correlatesPatient populationLongitudinal drinking patternsHigher oddsClinical relevanceHarmful drinkingAnnual administration