Effect of Baseline CD4 Cell Counts on the Clinical Significance of Short-Term Immunologic Response to Antiretroviral Therapy in Individuals With Virologic Suppression
Moore DM, Harris R, Lima V, Hogg B, May M, Yip B, Justice A, Mocroft A, Reiss P, Lampe F, Chêne G, Costagliola D, Elzi L, Mugavero MJ, Monforte AD, Sabin C, Podzamczer D, Fätkenheuer G, Staszewski S, Gill J, Sterne JA. Effect of Baseline CD4 Cell Counts on the Clinical Significance of Short-Term Immunologic Response to Antiretroviral Therapy in Individuals With Virologic Suppression. JAIDS Journal Of Acquired Immune Deficiency Syndromes 2009, 52: 357-363. PMID: 19668084, PMCID: PMC3032437, DOI: 10.1097/qai.0b013e3181b62933.Peer-Reviewed Original ResearchConceptsCombination antiretroviral therapyCD4 cell countBaseline CD4 cell countBaseline CD4 countCD4 countImmunologic responseVirologic suppressionCell countAntiretroviral therapyAbsolute CD4Absolute CD4 cell countCD4 cell count strataAdequate immunologic responseART Cohort CollaborationClear therapeutic goalsTreatment-naive individualsCell count strataCART initiationCohort CollaborationCD4 changeHazard ratioViral loadEligible participantsSubsequent prognosisClinical significance