2015
Emergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial
D’Onofrio G, O’Connor P, Pantalon MV, Chawarski MC, Busch SH, Owens PH, Bernstein SL, Fiellin DA. Emergency Department–Initiated Buprenorphine/Naloxone Treatment for Opioid Dependence: A Randomized Clinical Trial. JAMA 2015, 313: 1636-1644. PMID: 25919527, PMCID: PMC4527523, DOI: 10.1001/jama.2015.3474.Peer-Reviewed Original ResearchConceptsBrief intervention groupOpioid-dependent patientsIllicit opioid useAddiction treatment servicesPercent of patientsBuprenorphine groupEmergency departmentIntervention groupReferral groupOpioid useTreatment servicesBrief interventionOpioid dependenceClinical trialsHIV riskUrban teaching hospital emergency departmentBuprenorphine/naloxone treatmentHuman immunodeficiency virus (HIV) riskTeaching hospital emergency departmentAddiction treatmentBuprenorphine treatment groupUrine samplesBuprenorphine/naloxoneRandomized clinical trialsCommunity-based treatment services
1999
Lorazepam for the Prevention of Recurrent Seizures Related to Alcohol
D'Onofrio G, Rathlev N, Ulrich A, Fish S, Freedland E. Lorazepam for the Prevention of Recurrent Seizures Related to Alcohol. New England Journal Of Medicine 1999, 340: 915-919. PMID: 10094637, DOI: 10.1056/nejm199903253401203.Peer-Reviewed Original ResearchConceptsPlacebo groupRecurrent seizuresSecond seizureLorazepam groupEmergency departmentNormal salineAlcohol abusePrimary end pointDouble-blind studyChronic alcohol abuseYears of ageIntravenous lorazepamHospital dischargeConsecutive patientsGeneralized seizuresEntry criteriaCommon causePatientsSeizuresEnd pointLorazepamObservation periodSignificant reductionHospitalSaline
1994
The lack of efficacy of phenytoin in the prevention of recurrent alcohol-related seizures
Rathlev N, D'Onofrio G, Fish S, Harrison P, Bernstein E, Hossack R, Pickens L. The lack of efficacy of phenytoin in the prevention of recurrent alcohol-related seizures. Annals Of Emergency Medicine 1994, 23: 513-518. PMID: 8135426, DOI: 10.1016/s0196-0644(94)70070-2.Peer-Reviewed Original ResearchConceptsAlcohol-related seizuresSix-hour observation periodNormal saline placeboDouble-blind trialObservation periodConfidence intervalsLack of efficacyChronic alcohol abuseYears of ageChi 2 analysisPlacebo groupConsecutive adultsEligible subjectsPhenytoin groupSaline placeboGeneralized seizuresPhenytoin administrationSecond seizureEmergency departmentNormal salineRelative riskTeaching hospitalAlcohol abuseDrug AdministrationSeizures