2023
Computational phenotypes for patients with opioid-related disorders presenting to the emergency department
Taylor R, Gilson A, Schulz W, Lopez K, Young P, Pandya S, Coppi A, Chartash D, Fiellin D, D’Onofrio G. Computational phenotypes for patients with opioid-related disorders presenting to the emergency department. PLOS ONE 2023, 18: e0291572. PMID: 37713393, PMCID: PMC10503758, DOI: 10.1371/journal.pone.0291572.Peer-Reviewed Original ResearchConceptsSubstance use disordersUse disordersED visitsPatient presentationCarlson comorbidity indexOpioid-related diagnosesOpioid-related disordersOne-year survivalRate of medicationOpioid use disorderElectronic health record dataPatient-oriented outcomesYears of ageHealth record dataChronic substance use disordersED returnComorbidity indexAcute overdoseMedical managementClinical entityRetrospective studyEmergency departmentChronic conditionsInclusion criteriaUnique cohort
2022
Emergency department utilization for substance use disorders and mental health conditions during COVID-19
Venkatesh AK, Janke AT, Kinsman J, Rothenberg C, Goyal P, Malicki C, D’Onofrio G, Taylor A, Hawk K. Emergency department utilization for substance use disorders and mental health conditions during COVID-19. PLOS ONE 2022, 17: e0262136. PMID: 35025921, PMCID: PMC8757912, DOI: 10.1371/journal.pone.0262136.Peer-Reviewed Original ResearchConceptsOpioid use disorderOverall ED visitsED visitsEmergency departmentMental health conditionsAlcohol use disorderED visitationUse disordersED utilizationHospital-based emergency departmentsHealth conditionsEmergency department utilizationPublic health surveillance toolSite of careClinical quality registryEarly pandemic periodVisit countsSubstance use disordersCOVID-19COVID-19 pandemicED visit countsDiagnosis codesOutpatient treatmentMedicines RegistryQuality registry
2021
Implementation facilitation to introduce and support emergency department-initiated buprenorphine for opioid use disorder in high need, low resource settings: protocol for multi-site implementation-feasibility study
McCormack RP, Rotrosen J, Gauthier P, D’Onofrio G, Fiellin DA, Marsch LA, Novo P, Liu D, Edelman EJ, Farkas S, Matthews AG, Mulatya C, Salazar D, Wolff J, Knight R, Goodman W, Hawk K. Implementation facilitation to introduce and support emergency department-initiated buprenorphine for opioid use disorder in high need, low resource settings: protocol for multi-site implementation-feasibility study. Addiction Science & Clinical Practice 2021, 16: 16. PMID: 33750454, PMCID: PMC7941881, DOI: 10.1186/s13722-021-00224-y.Peer-Reviewed Original ResearchConceptsEmergency departmentLow-resource settingsImplementation facilitationUse disordersEmergency department-initiated buprenorphineResource settingsImplementation-effectiveness studyTreatment of OUDOpioid use disorderNon-emergent conditionsSubstance use disordersImplementation feasibility studyOUD interventionsED settingMedical recordsBuprenorphineClinical protocolsHigh needReferral programDisorder screeningDiscussionThis studyImplementation studyAdministrative dataReferralTreatmentFatal self-injury in the United States, 1999–2018: Unmasking a national mental health crisis
Rockett IRH, Caine ED, Banerjee A, Ali B, Miller T, Connery HS, Lulla VO, Nolte KB, Larkin GL, Stack S, Hendricks B, McHugh RK, White FMM, Greenfield SF, Bohnert ASB, Cossman JS, D'Onofrio G, Nelson LS, Nestadt PS, Berry JH, Jia H. Fatal self-injury in the United States, 1999–2018: Unmasking a national mental health crisis. EClinicalMedicine 2021, 32: 100741. PMID: 33681743, PMCID: PMC7910714, DOI: 10.1016/j.eclinm.2021.100741.Peer-Reviewed Original ResearchMental health crisisMental disordersSelf-injury mortalityDistrict of ColumbiaAnnual average percentage changeStandardised mortality ratiosSubstance use disordersDrug overdose deathsPublic health practiceHealth crisisRank-order correlation coefficientSuicide ratesAverage percentage changeUS National InstitutesMortality ratioInjury surveillanceUS CentersInjury preventionJoinpoint regressionOverdose deathsUse disordersDrug fatalitiesDeath dataDisease controlDrug availability
2019
Correction to: Emergency department screening and interventions for substance use disorders
Hawk K, D’Onofrio G. Correction to: Emergency department screening and interventions for substance use disorders. Addiction Science & Clinical Practice 2019, 14: 26. PMID: 31311584, PMCID: PMC6636051, DOI: 10.1186/s13722-019-0155-3.Peer-Reviewed Original Research
2018
Emergency department screening and interventions for substance use disorders
Hawk K, D’Onofrio G. Emergency department screening and interventions for substance use disorders. Addiction Science & Clinical Practice 2018, 13: 18. PMID: 30078375, PMCID: PMC6077851, DOI: 10.1186/s13722-018-0117-1.Peer-Reviewed Original Research
2017
Screening, treatment initiation, and referral for substance use disorders
Bernstein SL, D’Onofrio G. Screening, treatment initiation, and referral for substance use disorders. Addiction Science & Clinical Practice 2017, 12: 18. PMID: 28780906, PMCID: PMC5545867, DOI: 10.1186/s13722-017-0083-z.Peer-Reviewed Original ResearchConceptsUnhealthy alcohol useTreatment initiationSubstance useAlcohol useEfficacy of SBIRTSelf-reported abstinenceInitiation of buprenorphineOpioid-dependent individualsEmergency department settingClinical care settingsSubstance use disordersIndex visitAcute careOutpatient settingPrimary careMedication managementDepartment settingLeading causeAdult smokersPreventable deathsUnhealthy drinkersCare settingsNegative studiesMost trialsUse disorders