2019
Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial
Krishnan-Sarin S, O’Malley S, Franco N, Cavallo DA, Tetrault JM, Shi J, Gueorguieva R, Pittman B, Krystal JH. Influence of combined treatment with naltrexone and memantine on alcohol drinking behaviors: a phase II randomized crossover trial. Neuropsychopharmacology 2019, 45: 319-326. PMID: 31590179, PMCID: PMC6901445, DOI: 10.1038/s41386-019-0536-z.Peer-Reviewed Original ResearchConceptsAlcohol drinking behaviorFirst treatment periodTreatment periodNumber of drinksCrossover trialDrinking behaviorEfficacy of naltrexoneOpioid antagonist naltrexoneNMDA antagonist memantinePositive family historyDay treatment periodSelf-administration periodAlcohol-induced stimulationAd lib accessMemantine treatmentAntagonist naltrexoneOpioid systemFamily historyNTXPriming drinkMemantineNaltrexoneAlcohol cravingHeavy drinkersAlcohol dependence
2018
PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age
Vijay A, Cavallo D, Goldberg A, de Laat B, Nabulsi N, Huang Y, Krishnan-Sarin S, Morris ED. PET imaging reveals lower kappa opioid receptor availability in alcoholics but no effect of age. Neuropsychopharmacology 2018, 43: 2539-2547. PMID: 30188515, PMCID: PMC6224533, DOI: 10.1038/s41386-018-0199-1.Peer-Reviewed Original ResearchConceptsHealthy control cohortVolume of distributionOpioid receptor systemKappa-opioid receptorsOpioid receptorsDelta opioid receptor systemReceptor systemMu-opioid receptor systemOpioid receptor availabilityPotential pharmacological targetEffect of ageAge-related declineControl cohortPET scansAntagonist tracersReceptor availabilityMultivariate analysisPharmacological targetsPET imagingReceptorsAgePartial volume correctionCohortVT valuesPresent studyAddressing discordant quantitative urine buprenorphine and norbuprenorphine levels: Case examples in opioid use disorder
Holt SR, Donroe JH, Cavallo DA, Tetrault JM. Addressing discordant quantitative urine buprenorphine and norbuprenorphine levels: Case examples in opioid use disorder. Drug And Alcohol Dependence 2018, 186: 171-174. PMID: 29579725, DOI: 10.1016/j.drugalcdep.2017.12.040.Peer-Reviewed Original ResearchConceptsOngoing illicit drug usePatient-provider relationshipOpioid use disorderIllicit drug useUse disordersUrine adulterationTreatment planDrug useQuantitative urine testingMethadone treatment programsSubstance use disordersNorbuprenorphine levelsUrine buprenorphineUrine testingPatientsTreatment programNonjudgmental approachUrine samplesTherapeutic allianceDiscordant levelsBuprenorphineDisordersUrineNorbuprenorphineLevelsPreferring more e-cigarette flavors is associated with e-cigarette use frequency among adolescents but not adults
Morean ME, Butler ER, Bold KW, Kong G, Camenga DR, Cavallo DA, Simon P, O’Malley S, Krishnan-Sarin S. Preferring more e-cigarette flavors is associated with e-cigarette use frequency among adolescents but not adults. PLOS ONE 2018, 13: e0189015. PMID: 29300749, PMCID: PMC5754053, DOI: 10.1371/journal.pone.0189015.Peer-Reviewed Original ResearchConceptsE-cigarette useE-cigarette usersPast-month e-cigarette usersE-cigarette use frequencyE-cigarette flavorsE-liquidsMore daysFrequent e-cigarette useSchool-based surveyTotal numberFlavor preferencesAdult e-cigarette usersAdolescent e-cigarette useE-cigarettesUse frequencyAnalytic sampleAdultsSample of adolescentsAdolescentsGreater total numberLiquid flavorsConnecticut high schoolsAdult samplesLarge proportionDays
2017
The Addiction Recovery Clinic
Holt SR, Segar N, Cavallo DA, Tetrault JM. The Addiction Recovery Clinic. Academic Medicine 2017, 92: 680-683. PMID: 28441678, DOI: 10.1097/acm.0000000000001480.Peer-Reviewed Original ResearchConceptsPatient satisfaction surveyInternal medicine residentsRecovery clinicSubstance useMedicine residentsUse disordersAddiction medicine specialistsOpioid use disorderOutpatient clinical servicesPrimary care practicesUnhealthy substance useSubstance use disordersAddiction treatment facilitiesSatisfaction surveyDirect referralNew patientsMedicine specialistsPatientsCare practicesPatient encountersConsecutive weeksBehavioral treatmentAddiction medicineClinical servicesVisit number
2016
Current and Former Smokers’ Use of Electronic Cigarettes for Quitting Smoking: An Exploratory Study of Adolescents and Young Adults
Camenga DR, Kong G, Cavallo DA, Krishnan-Sarin S. Current and Former Smokers’ Use of Electronic Cigarettes for Quitting Smoking: An Exploratory Study of Adolescents and Young Adults. Nicotine & Tobacco Research 2016, 19: 1531-1535. PMID: 27663781, PMCID: PMC5896554, DOI: 10.1093/ntr/ntw248.Peer-Reviewed Original ResearchConceptsE-cigarette useFrequent e-cigarette useE-cigarettesSmokers' useSmoking cessationYoung adultsMore frequent e-cigarette useElectronic cigarettesSmoking cessation medicationsCigarette smoking statusE-cigarette use patternsSmoking medicationsCessation medicationsFormer smokersCurrent smokersSmoking statusComparative safetyQuitting smokingTobacco abstinenceWhite raceAdjusted modelPerceptions of harmfulnessE-cigarette flavorsSmokersSmoking
2015
N‐Methyl‐d‐Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers
Krishnan‐Sarin S, O'Malley SS, Franco N, Cavallo DA, Morean M, Shi J, Pittman B, Krystal JH. N‐Methyl‐d‐Aspartate Receptor Antagonism has Differential Effects on Alcohol Craving and Drinking in Heavy Drinkers. Alcohol Clinical And Experimental Research 2015, 39: 300-307. PMID: 25664775, PMCID: PMC4331214, DOI: 10.1111/acer.12619.Peer-Reviewed Original ResearchConceptsAlcohol drinkingFamily historyHeavy drinkersAlcohol cravingN-methyl-D-aspartate receptor antagonistN-methyl-D-aspartate receptor antagonismAlcohol cue-induced cravingEffects of FHHigher baseline levelsPresence of impulsivityAlcohol use disorderCue-induced cravingAlcohol-induced stimulationReceptor antagonismReceptor antagonistPriming doseNMDA receptorsUse disordersMemantineBaseline levelsModulatory influencePotential efficacyAlcohol accessDrinkersEighth day
2014
Reasons for Electronic Cigarette Experimentation and Discontinuation Among Adolescents and Young Adults
Kong G, Morean ME, Cavallo DA, Camenga DR, Krishnan-Sarin S. Reasons for Electronic Cigarette Experimentation and Discontinuation Among Adolescents and Young Adults. Nicotine & Tobacco Research 2014, 17: 847-854. PMID: 25481917, PMCID: PMC4674436, DOI: 10.1093/ntr/ntu257.Peer-Reviewed Original ResearchConceptsE-cigarette experimentationE-cigarettesCigarette smoking statusElectronic cigarette useTop reasonsSmoking statusCigarette smokersE-cigarette flavorsFocus groupsDiscontinuationCigarette useCigarette experimentationHealth concernPrevention effortsYoung adultsHealth risksSmokersSmokingGroupCigarettesYoung people
2013
Pubertal Status, Sensation-Seeking, Impulsivity, and Substance Use in High School–Aged Boys and Girls
Kong G, Smith AE, McMahon TJ, Cavallo DA, Schepis TS, Desai RA, Potenza MN, Krishnan-Sarin S. Pubertal Status, Sensation-Seeking, Impulsivity, and Substance Use in High School–Aged Boys and Girls. Journal Of Addiction Medicine 2013, 7: 116-121. PMID: 23370933, PMCID: PMC3618523, DOI: 10.1097/adm.0b013e31828230ca.Peer-Reviewed Original Research
2008
Contingency management for smoking cessation: enhancing feasibility through use of immunoassay test strips measuring cotinine.
Schepis TS, Duhig AM, Liss T, McFetridge A, Wu R, Cavallo DA, Dahl T, Jatlow P, Krishnan-Sarin S. Contingency management for smoking cessation: enhancing feasibility through use of immunoassay test strips measuring cotinine. Nicotine & Tobacco Research 2008, 10: 1495-501. PMID: 19023841, PMCID: PMC3679884, DOI: 10.1080/14622200802323209.Peer-Reviewed Original ResearchConceptsContingency managementAdolescent smokersTreatment-seeking adultsQuit attemptsSmoking cessationUse of cotinineUrinary cotinineBehavioral interventionsIntervention programsImmunoassay test stripUrinary cotinine levelsAbstinenceMultiple daily measurementsObjective indicatorsDaily appointmentsCotinine levelsCotinineImmunoassay testingGood markerAdultsBreath COVariety of substancesInterventionCessationSmokers
2007
Enhancing brief cognitive-behavioral therapy with motivational enhancement techniques in cocaine users
McKee SA, Carroll KM, Sinha R, Robinson JE, Nich C, Cavallo D, O’Malley S. Enhancing brief cognitive-behavioral therapy with motivational enhancement techniques in cocaine users. Drug And Alcohol Dependence 2007, 91: 97-101. PMID: 17573205, PMCID: PMC2386854, DOI: 10.1016/j.drugalcdep.2007.05.006.Peer-Reviewed Original ResearchConceptsCognitive behavioral therapyMotivational enhancement therapyBrief cognitive behavioral therapyMotivational enhancement techniquesSpecific treatment componentsCocaine usersExpectations of successMotivational interviewing techniquesCBT conditionCocaine useEnhancement therapyTreatment componentsIntervention paradigmInterviewing techniquesTherapy processMixed supportCocaine abuseInitial sessionTreatment retentionThree-sessionGreater desireGreat difficultyTreatment conditionsTreatment sessionsProcess measures