Ania Jastreboff, MD, PhD

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About

Honors

7 National Awards
3 Yale School of Medicine Awards
1 Yale University Award

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Activities

190 Activities
2006 - Present
18 Countries

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Service

1 Committee
12 Professional Organizations

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Titles

Associate Professor of Medicine (Endocrinology)

Director, Yale Obesity Research Center (Y-Weight)

Co-Director, Yale Center for Weight Management

Medical Director, Yale Stress Center

Education

PhD
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)

MD
University of Maryland at Baltimore (2002)

Appointments

Endocrinology

Primary

General Pediatrics

Secondary

Are You a Patient?

View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

View Doctor Profile

Board Certification

Obesity Medicine
2016

Endocrinology Diabetes & Metabolism
2012

Clinical Specialties

Obesity Medicine, Pediatric Endocrinology & Diabetes + 2 more

Patients Treated

Child, Adolescent, Adult

Honors

7 National Awards
3 Yale School of Medicine Awards
1 Yale University Award

Learn more

Activities

190 Activities
2006 - Present
18 Countries

Learn more

Service

1 Committee
12 Professional Organizations

Learn more

Titles

Associate Professor of Medicine (Endocrinology)

Director, Yale Obesity Research Center (Y-Weight)

Co-Director, Yale Center for Weight Management

Medical Director, Yale Stress Center

Education

PhD
Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)

MD
University of Maryland at Baltimore (2002)

Appointments

Endocrinology

Primary

General Pediatrics

Secondary

Are You a Patient?

View this doctor's clinical profile on the Yale Medicine website for information about the services we offer and making an appointment.

View Doctor Profile

Board Certification

Obesity Medicine
2016

Endocrinology Diabetes & Metabolism
2012

Clinical Specialties

Obesity Medicine, Pediatric Endocrinology & Diabetes + 2 more

Patients Treated

Child, Adolescent, Adult

Honors

7 National Awards
3 Yale School of Medicine Awards
1 Yale University Award

Learn more

Activities

190 Activities
2006 - Present
18 Countries

Learn more

Service

1 Committee
12 Professional Organizations

Learn more

About

Titles

Associate Professor of Medicine (Endocrinology)

Director, Yale Obesity Research Center (Y-Weight); Co-Director, Yale Center for Weight Management; Medical Director, Yale Stress Center

Biography

Ania M. Jastreboff, MD, PhD is an Associate Professor in Medicine and Pediatrics at Yale School of Medicine. She serves as the director of the Yale Obesity Research Center (Y-Weight) and the co-director of the Yale Center for Weight Management. She is trained in both adult endocrinology and pediatric endocrinology, is an obesity medicine physician-scientist, and an international leader in research and clinical application of anti-obesity pharmacotherapeutics. Her work has included working to develop Obesity Clinical Practice Guidelines (AACE/ACE 2016), serving on the Board of Directors for the American Board of Obesity Medicine, educating the next generation of Obesity Medicine physicians by teaching at national and international obesity treatment courses, and conducting cutting-edge clinical-translational obesity research. Her research includes large, multi-center clinical outcomes trials using novel anti-obesity pharmacotherapeutics and studies examining the neurobiology underlying obesity and mechanisms of anti-obesity medications (supported by the NIH/NIDDK). Recently, she has served as lead author for trials investigating potential novel nutrient-stimulated hormone-based therapies for obesity including dual hormone receptor agonist tirzepatide (NEJM) a novel GIP/GLP-1 receptor agonist (Jastreboff, et al., NEJM, 2022) and triple hormone receptor agonist retatrutide (NEJM) a novel GIP/GLP-1/Glucagon receptor agonist (Jastreboff, et al., NEJM, 2023). Dr. Jastreboff thoughtfully advocates for compassionate care for patients with obesity and was recently interviewed Oprah.

Videos of Dr. Jastreboff and colleagues from the NEJM about:

- What causes obesity: https://www.nejm.org/doi/full/...

- Supporting patients with obesity: https://www.nejm.org/doi/full/...

- Medications and surgery for obesity treatment: https://www.nejm.org/doi/full/...

Yale video with Dr. Jastreboff about anti-obesity medications and the biology of obesity.

Podcast (Yale Talk) with the president of Yale University, Dr. Peter Salovey, speaking with Dr. Jastreboff.

Clinically, Dr. Jastreboff specializes in sophisticated use of anti-obesity medication combinations to help patients reach their weight and health goals.

Appointments

Endocrinology
Associate Professor on Term
Primary
Endocrinology
General Pediatrics
Associate Professor on Term
Secondary
General Pediatrics

Center for Weight Management
Diabetes Center
Diabetes Program
Diabetes Research Center
Endocrinology
General Pediatrics
Internal Medicine
Obesity Research Working Group
Pediatric Weight Solutions Program
Status of Women in Medicine Committee (SWIM)
Yale Medicine
Yale Obesity Research Center (Y-Weight)
Yale Stress Center

Education & Training

Student - Yale Advanced Emerging Leaders: Yale University (2023)

Yale Public Voices Fellowship: Yale University (2022)

Clinical Scholar: Yale University School of Medicine (2013)

YCCI Clinical Research Scholar: Yale School of Medicine (2013)

PhD: Yale University Graduate School of Arts and Sciences, Investigative medicine (2012)

Neuromanaging in Psychiatry: Yale School of Medicine (2011)

Postdoctoral Fellowship: Yale School of Medicine (2011)

Postdoctoral Fellowship: Yale School of Medicine (2011)

Food Policy and Science: Yale University (2010)

Learning to Mentor the next generation of scientists: Yale School of Medicine (2009)

Nutrition and Chronic Disease: Yale University (2009)

Chief Resident: University of Maryland (2006)

Residency: University of Maryland School of Medicine (2006)

Intern: University of Maryland (2003)

MD: University of Maryland at Baltimore (2002)

BA: Bucknell University, Art History/Major, Music/Minor. Magna cum laude (1998)

Research

Overview

obesity and cancer; anti-obesity pharmacotherapy; cancer prevention and risk reduction

Medical Subject Headings (MeSH)

Obesity; Weight Loss

ORCID
0000-0003-1446-0991
Y-Weight: Yale Obesity Research Center
Investigating novel pharmacological therapeutics for obesity treatment and probing the mechanisms of obesity in translational physiology studies
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Research at a Glance

Yale Co-Authors

Frequent collaborators of Ania Jastreboff's published research.

Rajita Sinha, PhD
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View 5 Common Publications
Wendy Silverman, PhD, ABPP
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View 4 Common Publications
Michelle Van Name, MD
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View 3 Common Publications
Carlos Grilo, PhD
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View 2 Common Publications
Christopher Maulion, MD
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View 2 Common Publications
Clancy Mullan, MD
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View 2 Common Publications

Publications

2024

GLP-1 programs the neurovascular landscape
Chen B, Yu X, Horvath-Diano C, Ortuño M, Tschöp M, Jastreboff A, Schneeberger M. GLP-1 programs the neurovascular landscape. Cell Metabolism 2024, 36: 2173-2189. PMID: 39357509, DOI: 10.1016/j.cmet.2024.09.003.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Considerations for the design and conduct of pediatric obesity pharmacotherapy clinical trials: Proceedings of expert roundtable meetings
Kelly A, Bahlke M, Baker J, de Beaufort C, Belin R, Fonseca H, Hale P, Holm J, Hsia D, Jastreboff A, Juliusson P, Murphy M, Pak J, Paul E, Rudolph B, Srivastava G, Tornøe C, Weghuber D, Fox C. Considerations for the design and conduct of pediatric obesity pharmacotherapy clinical trials: Proceedings of expert roundtable meetings. Pediatric Obesity 2024, 19: e13161. PMID: 39289849, DOI: 10.1111/ijpo.13161.
Peer-Reviewed Original Research
Concepts
Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial
Deanfield J, Verma S, Scirica B, Kahn S, Emerson S, Ryan D, Lingvay I, Colhoun H, Plutzky J, Kosiborod M, Hovingh G, Hardt-Lindberg S, Frenkel O, Weeke P, Rasmussen S, Goudev A, Lang C, Urina-Triana M, Pietilä M, Lincoff A, Investigators S, Abe M, Abhaichand R, Abhayaratna W, Abhyankar A, Abidin I, Assi H, Mendoza J, Adas M, Agaiby J, Agarwal D, Agha M, Ahmed A, Ahtiainen P, Aigner E, Ajay N, Ali N, Al-Karadsheh A, Allison R, Allison D, Alpenidze D, Altuntas Y, Al-Zoebi A, Ambuj R, Amerena J, Anderson R, Ando T, Andrews R, Antonova E, Appel K, Arantes F, Araz M, Arbel Y, León J, Argyrakopoulou G, Ariani M, Mendoza M, Arif A, Arneja J, Aroda V, Aronne L, Arstall M, Asamoah N, Asanin M, Audish H, Avram R, Badat A, Badiu C, Bakdash W, Bakiner O, Bandezi V, Bang L, Bansal S, Baranyai M, Barbarash O, Barber M, Barnum O, Rochette G, Bashkin A, Baum S, Bays H, Ruiz A, Beckowski M, Beerachee Y, Bellary S, Belousova L, Berk M, Bernstein M, Berra C, Beshay I, Bhagwat A, Bhan A, Biggs W, Billings L, Bitar F, Block B, Bo S, Bogdanski P, Bolshakova O, Boshchenko A, Bosworth H, Lopez R, Bôttcher M, Bourgeois R, Brautigam D, Breton C, Broadley A, Brockmyre A, Brodie S, Bucci M, Budincevic H, Budoff M, Buffman B, Buljubasic N, Buranapin S, Burgess L, Burguera B, Buriakovska O, Buscemi S, Busch R, Buse J, Buynak R, Byrne M, Caceaune E, Bonfanti A, Calinescu C, Call R, Varzic S, Cannon K, Capehorn M, Cariou B, Carr J, Carrillo-Jimenez R, Casas M, Castro A, Celik A, Cercato C, Cermak O, Y J, Chacon C, Chaicha-Brom T, Chandra S, Chettibi M, Chevts J, Christopher J, Chrustowski W, Cif A, Clark R, Clark W, Clifford P, Coetzee K, Cogni G, Colao A, Colquhoun D, Concha M, Condit J, Constance C, Constantin C, Constantinescu S, Corbett C, Cornett G, Correia M, Cortinovis F, Cosma D, Creely S, Cross D, Curtis B, Czochra W, Daboul N, Dagdelen S, D'agostino R, Dang C, Datta S, Davuluri A, Dawood S, De Jong D, De La Cuesta C, De Los Rios Ibarra M, De Pablo C, De Pauw M, Dela Llana A, Delibasic M, Delic-Brkljacic D, Demicheli T, Denger R, Desai D, Desai P, Desouza C, Dicker D, Djenic N, Dobson S, Doi M, Doran J, Dorman R, Dotta F, Dukes C, Duronto E, Durst R, Dvoryashina I, Ebrahim I, Eggebrecht H, Egstrup K, Ekinci E, Eliasson B, Eliasson K, Enache G, Enculescu D, English P, Ermakova P, Ershova O, Ezaki H, Ezhov M, Farias E, Farias J, Farsky P, Ferreira D, Filteau P, Finneran M, Folkens E, Fonseca A, Fonseca L, Fordan S, Fourie N, França S, Franco D, Franek E, Friedman K, Frittitta L, Froer M, Fuckar K, Fujii K, Fujita R, Fukushima Y, Fulat M, Fulwani M, Gajos G, Galyavich A, Gambill M, Gandotra D, Winston G, Hernandez P, Reza R, Garg N, Garg S, Garvey W, Garza J, Gatta-Cherifi B, Gelev V, Geller S, Geohas J, Georgiev B, Ghazi A, Gilbert M, Gilinskaya O, Gislason G, Yavuz D, Albarrán O, Gordeev I, Gorton S, Goudev A, Valderhaug T, Groenemeijer B, Gul I, Gullestad L, Gurieva I, Guseva G, Hagenow A, Haluzik M, Halvorsen S, Hammoudi N, Hanaoka K, Hancu N, Hanusch U, Harris K, Harris B, Hartleib M, Hartman A, Hata Y, Heimer B, Herman L, Herzog W, Hewitt E, Heymer P, Hiremath S, Hjelmesaeth J, Høgalmen R, Høivik H, Holmer H, Horoshko O, Houser P, Hove J, Hsieh I, Hulot J, Hussein Z, Ilashchuk T, Ilveskoski E, Ipatko I, Iranmanesh A, Isawa T, Issa M, Iteld B, Iwasawa T, Jabbar D, Jackson R, Jackson-Voyzey E, Jacob S, Jaffrani N, Jardula M, Jastreboff A, Jensen S, Jerkins T, Jimenez-Ramos S, Singh S, Johnson W, Joyce J, Jozefowska M, Jugnundan P, Jungmair W, Jurowiecki J, Kadokami T, Kahali D, Kahrmann G, Kaiser S, Kalmucki P, Kanadasi M, Kandath D, Kania G, Kannan J, Kapp C, Karczmarczyk A, Kartalis A, Kaser S, Kasim S, Kastelic R, Kato T, Katova T, Kaul U, Kautzky-Willer A, Kawanishi M, Kayikcioglu M, Kazakova E, Keeling P, Kempe H, Kereiakes D, Kerneis M, Keski-Opas T, Khadra S, Khaisheva L, Kharakhulakh M, Khlevchuk T, Khoo J, Kiatchoosakun S, Kinoshita N, Kinoshita M, Kitamura R, Kiyosue A, Klavina I, Klein E, Klimsa Z, Klonoff D, Klug E, Kobalava Z, Kodera S, Koga T, Kokkinos A, Koleckar P, Könyves L, Koren M, Kormann A, Kostner K, Kreutzmann K, Krishinan S, Krishnasamy S, Krivosheeva I, Kruljac I, Kubicki T, Kuchar L, Kujawiak M, Kunishige H, Kurtinecz M, Lisboa H, Kushnir M, Kyyak Y, Lace A, Lakka T, Lalic N, Lalic K, Lambadiari V, Lanaras L, Lang C, Langlois M, Lash J, Latkovskis G, Lau D, Soto J, Le Roux C, Ledesma G, Lee L, Lee T, Lee K, Lehrke M, Leite S, Leksycka A, Lenzmeier T, Leonetti F, Leonidova V, Lepor N, Leung M, Levchenko O, Levins P, Levy L, Lewis M, Liberopoulos E, Liberty I, Lindholm C, Lingvay I, Linhart A, Liu M, Liu J, Lofton H, Logemann T, Lombaard J, Lombard L, Lorraine R, Lovell C, Ludvik B, Lukaszewicz M, Lupkovics G, Lupovitch S, Lupu S, Lynch M, Lysak Z, Lysenko T, Maeda H, Maeda I, Mæng M, Mahajan A, Maher V, Maia L, Makotoko E, Malavazos A, Malecha J, Malicherova E, Manita M, Mannucci E, Mareev V, Marin L, Markova T, Marso S, Martens F, Martinez C, Cano C, Martins C, Comas L, Matsumoto T, Mcdonald K, Mcgowan B, Mcgrew F, Mclean B, Mcpherson D, Torres J, Meyers P, Meyhöfer S, Raya P, Milanova M, Milicic D, Miller G, Mills R, Mîndrescu N, Mingrone G, Minkova D, Mirani M, Miras A, Mistodie C, Mitomo S, Mittal S, Miyake T, Miyamoto N, Molony D, Monteiro P, Mooe T, Moosa N, Portillo C, Villegas E, Morawski E, Morbey C, Morin R, Morisaki K, Morosanu M, Mosenzon O, Mostovoy Y, Munir I, Muratori F, Murray R, Murthy A, Myint M, Myshanych G, Nafornita V, Nagano T, Nair S, Nakhle S, Natsuaki M, Nayak B, Nibouche D, Nicholls S, Nicolau J, Nicolescu G, Nierop P, Niskanen L, Ntaios G, Nygård O, Oaks J, Obrezan A, O'donnell P, Oguri M, Oguzhan A, Oh F, Ohsugi M, Okada Y, Okayama H, Onaca A, Onaka H, Oneil P, Ong T, Ong S, Ono Y, Opsahl P, Ostrowska L, Oviedo A, Ozdogan O, Ozpelit E, Pagkalos E, Pagotto U, Páll D, Pandey A, Parkhomenko O, Parvathareddy K, Patel M, Patsilinakos S, Paul N, Pedersen S, Pereira I, Pereira E, Terns P, Perez-Vargas E, Pergaeva Y, Perkelvald A, Peskov A, Peter J, Peters K, Petit C, Petrov I, Philis-Tsimikas A, Pietilä M, Pinto F, Piros A, Piyayotai D, Platonov D, Poirier P, Pop L, Popa B, Pop-Busui R, Poremba J, Porto A, Postadzhiyan A, Pothineni R, Potu R, Powell T, Prafulla K, Prager R, Prakova-Teneva Z, Pratley R, Price H, Pulka G, Pullman J, Punt Z, Purighalla R, Purnell P, Qureshi M, Rabasa-Lhoret R, Raikhel M, Rancane G, Randeva H, Rasouli N, Pintilei D, Reyes C, Rezgale I, Rice E, Riley T, Risser J, Ristic A, Fernández M, Robbins D, Robitaille Y, Rodbard H, Plazas J, Römer T, Rosen G, Rosman A, Rossi P, Rudenko L, Ruffin O, Ruhani A, Runev N, Ruyatkin D, Ruzic A, Ryabov V, Rydén L, Saggar S, Sakamoto T, Salter T, Samal A, Samoilova Y, Sanabria H, Sancak S, Sangrigoli R, Sansanayudh N, Santini F, Saraiva J, Sardinov R, Sargeant W, Sari R, Sathananthan A, Sathyapalan T, Sato A, Sauter J, Sbraccia P, Schaap J, Schaum T, Schiele F, Scott J, Lieberman G, Segner A, Senior R, Sergeeva-Kondrachenko M, Serota H, Serusclat P, Sethi R, Shah M, Shah N, Shalaev S, Sharma R, Sharma S, Shaydyuk O, Shea H, Shechter M, Shehadeh N, Shirazi M, Shlesinger Y, Shneker A, Shutemova E, Siasos G, Siddiqui I, Sidey J, Sigal F, Sime I, Singh N, Siraj E, Sivalingam K, Skoczylas G, Smith S, Smolenskaya O, Snyder B, Sofer Y, Sofley C, Solano R, Sonmez Y, Sorokin M, González A, Sotolongo C, Soufer J, Selcukbiricik O, Spaic T, Spriggs D, Sreenan S, Stahl H, Stamatelopoulos K, Stanislavchuk M, Stankovic G, Stasek J, Steg G, Steindorf J, Stephan D, Stewart J, Still C, St-Maurice F, Stogowska-Nikiciuk B, Stoker J, Stokic E, Strzelecka A, Sturm K, Sueyoshi A, Sugiura T, Sultan S, Suplotova L, Suwanagool A, Suwanwalaikorn S, Sveklina T, Swanson N, Swart H, Swenson B, Szyprowska E, Tait G, Takács R, Takeuchi Y, Tamirisa A, Tanaka H, Tatovic D, Tellier G, Teragawa H, Teterovska D, Thomas N, Thuan J, Tinahones F, Tisheva-Gospodinova S, Toarba C, Todoriuk L, Tokmakova M, Tonstad S, Toplak H, Tran H, Tripathy D, Trusau A, Tsabedze N, Tsougos E, Tsoukas G, Tuccinardi D, Tuna M, Turatti L, Tziomalos K, Udommongkol C, Ueda O, Ukkola O, Unubol M, Urbach D, Triana M, Usdan L, Vaidya B, Vale N, Vallieres G, Van Beek A, Van De Borne P, Van Der Walt E, Van Der Zwaan C, Van Nieuwenhuizen E, Van Zyl L, Vanduynhoven P, Varghese K, Vasileva S, Vassilev D, Vathesatogkit, Velychko V, Vercammen C, Verges B, Verma S, Verwerft J, Vesela A, Veselovskaya N, Vettor R, Veze I, Vijan V, Vijayaraghavan R, Villarino A, Vincent R, Vinogradova O, Vishlitzky V, Vlad A, Vladu I, Vo A, Von Engelhardt C, Von Münchhausen C, Vorobyeva O, Vossenberg T, Vrolix M, Vukicevic M, Vyshnyvetskyy I, Wadvalla S, Wagner J, Wakeling J, Wallace J, Mohamed W, Wander G, Ward K, Warren M, Watanabe A, Weber B, Weintraub H, Weisnagel J, Welker J, Wendisch U, Wenocur H, Wierum C, Wilding J, William M, Wilson P, Wilson J, Wong Y, Wongcharoen W, Wozniak I, Wu C, Wyatt N, Wynne A, Yamaguchi H, Yamasaki M, Yazici D, Yeh H, Yotov Y, Yuan Q, Zacher J, Zagrebelnaya O, Zaidman C, Zalevskaya A, Zarich S, Zatelli M, Zeller H, Zhdanova E, Zornitzki T, Zrazhevskiy K, Zykov M, Lincoff A, Ryan D, Colhoun H, Deanfield J, Emerson S, Kahn S, Kushner R, Plutzky J, Brown-Frandsen K, Hovingh G, Hardt-Lindberg S, Tornøe C. Semaglutide and cardiovascular outcomes in patients with obesity and prevalent heart failure: a prespecified analysis of the SELECT trial. The Lancet 2024, 404: 773-786. PMID: 39181597, DOI: 10.1016/s0140-6736(24)01498-3.
Peer-Reviewed Original Research
MeSH Keywords and Concepts
Ending Weight Stigma to Advance Health Equity
Pearl R, Donze L, Rosas L, Agurs-Collins T, Baskin M, Breland J, Byker Shanks C, Cooksey Stowers K, Johnson S, Lee B, Martin M, Mujuru P, Odoms-Young A, Panza E, Pronk N, Calicutt K, Nadglowski J, Nece P, Tedder M, Chow L, Krishnamurti H, Jay M, Xi D, Jastreboff A, Stanford F. Ending Weight Stigma to Advance Health Equity. American Journal Of Preventive Medicine 2024, 67: 785-791. PMID: 38945180, DOI: 10.1016/j.amepre.2024.06.021.
Peer-Reviewed Original Research
Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial
Kahn S, Deanfield J, Jeppesen O, Emerson S, Boesgaard T, Colhoun H, Kushner R, Lingvay I, Burguera B, Gajos G, Horn D, Hramiak I, Jastreboff A, Kokkinos A, Maeng M, Matos A, Tinahones F, Lincoff A, Ryan D, Investigators S. Effect of Semaglutide on Regression and Progression of Glycemia in People With Overweight or Obesity but Without Diabetes in the SELECT Trial. Diabetes Care 2024, 47: 1350-1359. PMID: 38907683, PMCID: PMC11282386, DOI: 10.2337/dc24-0491.
Peer-Reviewed Original Research
Concepts
DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases
Handelsman Y, Anderson J, Bakris G, Ballantyne C, Bhatt D, Bloomgarden Z, Bozkurt B, Budoff M, Butler J, Cherney D, DeFronzo R, Del Prato S, Eckel R, Filippatos G, Fonarow G, Fonseca V, Garvey W, Giorgino F, Grant P, Green J, Greene S, Groop P, Grunberger G, Jastreboff A, Jellinger P, Khunti K, Klein S, Kosiborod M, Kushner P, Leiter L, Lepor N, Mantzoros C, Mathieu C, Mende C, Michos E, Morales J, Plutzky J, Pratley R, Ray K, Rossing P, Sattar N, Schwarz P, Standl E, Steg P, Tokgözoğlu L, Tuomilehto J, Umpierrez G, Valensi P, Weir M, Wilding J, Wright E. DCRM 2.0: Multispecialty practice recommendations for the management of diabetes, cardiorenal, and metabolic diseases. Metabolism 2024, 159: 155931. PMID: 38852020, DOI: 10.1016/j.metabol.2024.155931.
Peer-Reviewed Original Research
Concepts
Once-weekly Triple Receptor (GIP/GLP-1/Glucagon) Agonist Retatrutide (LY3437943): Efficacy and Safety in a 48-week Obesity Phase 2 Trial
Jastreboff A, Kaplan L, Frias J, Wu Q, Du Y, Gurbuz S, Coskun T, Haupt A, Milicevic Z, Hartman M, Blüher M. Once-weekly Triple Receptor (GIP/GLP-1/Glucagon) Agonist Retatrutide (LY3437943): Efficacy and Safety in a 48-week Obesity Phase 2 Trial. Diabetologie Und Stoffwechsel 2024, 19: s77-s78. DOI: 10.1055/s-0044-1785389.
Peer-Reviewed Original Research
Concepts
Retatrutide, a triple GIP/GLP-1/glucagon receptor agonist, provides robust HbA1c and body weight reductions to people with type 2 diabetes: a 36--week, phase 2 study
Coskun T, Rosenstock J, Frias J, Jastreboff A, Du Y, Lou J, Gurbuz S, Hartman M, Haupt A, Milicevic Z, Seufert J. Retatrutide, a triple GIP/GLP-1/glucagon receptor agonist, provides robust HbA1c and body weight reductions to people with type 2 diabetes: a 36--week, phase 2 study. Diabetologie Und Stoffwechsel 2024, 19: s72-s73. DOI: 10.1055/s-0044-1785379.
Peer-Reviewed Original Research
Concepts

2023

Reflecting on a Year at the Helm of Diabetes Care.
Kahn S, Anderson C, Buse J, Selvin E, Angell S, Aroda V, Cheng A, Danne T, Echouffo-Tcheugui J, Fitzpatrick S, Gadgil M, Gastaldelli A, Gloyn A, Green J, Jastreboff A, Kanaya A, Kandula N, Kovesdy C, Laiteerapong N, Nadeau K, Pettus J, Pop-Busui R, Posey J, Powe C, Rebholz C, Rickels M, Sattar N, Shaw J, Sims E, Utzschneider K, Vella A, Zhang C. Reflecting on a Year at the Helm of Diabetes Care. Diabetes Care 2023, 47: 4-6. PMID: 38117988, DOI: 10.2337/dci23-0089.
Peer-Reviewed Original Research
Eligibility for Cardiovascular Risk Reduction Therapy in the United States Based on SELECT Trial Criteria: Insights From the National Health and Nutrition Examination Survey
Lu Y, Liu Y, Jastreboff A, Khera R, Ndumele C, Rodriguez F, Watson K, Krumholz H. Eligibility for Cardiovascular Risk Reduction Therapy in the United States Based on SELECT Trial Criteria: Insights From the National Health and Nutrition Examination Survey. Circulation Cardiovascular Quality And Outcomes 2023, 17: e010640. PMID: 37950677, PMCID: PMC10782930, DOI: 10.1161/circoutcomes.123.010640.
Peer-Reviewed Original Research
Concepts

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Clinical Trials

Current Trials

EMANATE: A Study of Setmelanotide in Patients With Specific Gene Variants in the MC4R Pathway
HIC ID2000032942RolePrincipal InvestigatorPrimary Completion Date09/30/2024
Recruiting ParticipantsGenderBothAge6 years - 65 years
GeneticsMental Health & Behavioral Research
Treatments to Treat Loss-of-Control Eating and Improve Weight Outcomes after Bariatric Surgery
HIC ID2000029057RoleSub InvestigatorPrimary Completion Date11/30/2027
Recruiting Participants
Obesity & Weight ManagementDigestive System
GLP-1 analogue effects on food cues, stress, motivation for highly palatable foods, and weight
HIC ID2000027868RolePrincipal InvestigatorPrimary Completion Date06/30/2025
Recruiting ParticipantsGenderBothAge18 years - 55 years
Mental Health & Behavioral ResearchObesity & Weight Management
Impact of Hypoglycemia on Brain Ketone and Neurotransmitter Metabolism in Type 1 DM
HIC ID1208010648RoleSub InvestigatorPrimary Completion Date09/29/2022
Recruiting ParticipantsGenderBothAge18+ years
DiabetesEndocrine SystemBrain, Spinal Cord & Nervous System
Prevalence of Carbohydrate Intolerance in Lean and Obese Children
HIC ID9909011190RoleSub InvestigatorPrimary Completion Date09/30/2025
Recruiting ParticipantsGenderBothAge8 years - 18 years
Children's HealthDiabetesHeart/CardiovascularEndocrine SystemGeneticsObesity & Weight Management

Academic Achievements & Community Involvement

activity
The Obesity Society
Peer Review Groups and Grant Study SectionsReviewer
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activity
The Endocrine Society
Professional OrganizationsCommittee Member
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activity
ADA (American Diabetes Association)
Meeting Planning and ParticipationMember
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Obesity - National Childhood Obesity Awareness Month Special Issue
Journal ServiceAssociate Editor
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Diabetes Care
Journal ServiceAssociate Editor
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Clinical Care

Overview

Ania M. Jastreboff, MD, PhD, is an adult and pediatric endocrinologist with expertise in obesity medicine and weight management. She cares for patients who have prediabetes, insulin resistance, metabolic syndrome, and type 1 and type 2 diabetes.

Dr. Jastrebroff, who is director of the Yale Obesity Research Center (Y-Weight), says she empathizes with patients who struggle to lose weight or maintain weight loss. “Carrying excess weight and having obesity is not a lifestyle choice. Obesity is a chronic disease and should be treated with the same vigor and integrity as other chronic diseases,” she says. “We are in the infancy of our understanding of the mechanisms that underlie obesity. Many novel treatments are under development, including new anti-obesity medications, endoscopic procedures, and the refining of behavioral and surgical interventions.”

An assistant professor of medicine (endocrinology) and of pediatrics (endocrinology) at Yale School of Medicine, Dr. Jastrebroff says one of her goals is to conduct clinic research that will lead to better treatments for obesity and also have a clear public health impact in mitigating the obesity “pandemic.”

Obesity Medicine; Pediatric Endocrinology & Diabetes; Diabetes Medicine & Management; Endocrinology

Fact Sheets

Diabetes: Symptoms, Causes, and Treatments
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Type 2 Diabetes: Symptoms and Treatments
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Gastric Balloon (Intragastric Balloon)
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Vitamin D Deficiency
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Board Certifications

Obesity Medicine
Certification Organization
AB of Obesity Medicine
Original Certification Date
2016
Endocrinology Diabetes & Metabolism
Certification Organization
AB of Internal Medicine
Original Certification Date
2012

Yale Medicine News

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Contacts

Appointment Number

877.925.3637

Administrative Support

Alexandra Tavakoli
Associate Director 2

Locations

Patient Care Locations
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About

Titles

Education

Appointments

Titles

Biography

Appointments

Endocrinology

General Pediatrics

Other Departments & Organizations

Education & Training

Overview

Medical Subject Headings (MeSH)

ORCID

Y-Weight: Yale Obesity Research Center

Research at a Glance

Yale Co-Authors

Rajita Sinha, PhD

Wendy Silverman, PhD, ABPP

Michelle Van Name, MD

Carlos Grilo, PhD

Christopher Maulion, MD

Clancy Mullan, MD

Publications

2024

2023

Clinical Trials

Current Trials

The Obesity Society

The Endocrine Society

ADA (American Diabetes Association)

Obesity - National Childhood Obesity Awareness Month Special Issue

Diabetes Care

Overview

Clinical Specialties

Fact Sheets

Diabetes: Symptoms, Causes, and Treatments

Type 2 Diabetes: Symptoms and Treatments

Gastric Balloon (Intragastric Balloon)

Vitamin D Deficiency

Board Certifications

Obesity Medicine

Endocrinology Diabetes & Metabolism

Yale Medicine News

Prediabetes Is on the Rise—But It Can Be Reversed

The Biology of Obesity: Why Keeping Weight Off Is So Hard

Are You a Patient?

News

Yale Researchers at American Heart Association Scientific Session 2024

Ania Jastreboff: The Transformative Obesity Drugs

The Race for the Next Ozempic

6 types of foods and drinks to avoid when taking Ozempic or Wegovy for weight loss