2023
The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events
Menez S, Wen Y, Xu L, Moledina D, Thiessen-Philbrook H, Hu D, Obeid W, Bhatraju P, Ikizler T, Siew E, Chinchilli V, Garg A, Go A, Liu K, Kaufman J, Kimmel P, Himmelfarb J, Coca S, Cantley L, Parikh C. The ASSESS-AKI Study found urinary epidermal growth factor is associated with reduced risk of major adverse kidney events. Kidney International 2023, 104: 1194-1205. PMID: 37652206, PMCID: PMC10840723, DOI: 10.1016/j.kint.2023.08.007.Peer-Reviewed Original ResearchConceptsMajor adverse kidney eventsUEGF/CrUrinary epidermal growth factorAdverse kidney eventsChronic kidney diseaseEpidermal growth factorKidney eventsKidney failureEGF expressionUrinary EGF/CrAcute Kidney Injury studyGrowth factorIschemia-reperfusion injuryProportional hazards regressionTubular healthKidney atrophyObservational cohortHospitalized participantsTubular functionClinical findingsHazards regressionKidney diseaseClinical variablesProgressive atrophyUrinary EGF
2021
Urinary EGF and MCP-1 and risk of CKD after cardiac surgery
Menez S, Ju W, Menon R, Moledina DG, Thiessen Philbrook H, McArthur E, Jia Y, Obeid W, Mansour SG, Koyner JL, Shlipak MG, Coca SG, Garg AX, Bomback AS, Kellum JA, Kretzler M, Parikh CR, . Urinary EGF and MCP-1 and risk of CKD after cardiac surgery. JCI Insight 2021, 6: e147464. PMID: 33974569, PMCID: PMC8262289, DOI: 10.1172/jci.insight.147464.Peer-Reviewed Original ResearchMeSH KeywordsAcute Kidney InjuryAgedAged, 80 and overCardiac Surgical ProceduresChemokine CCL2Disease ProgressionEpidermal Growth FactorFemaleGene Expression ProfilingHumansIncidenceMalePostoperative ComplicationsProportional Hazards ModelsRenal Insufficiency, ChronicRNA, MessengerRNA-SeqSingle-Cell AnalysisConceptsAcute kidney injuryCardiac surgeryMCP-1CKD outcomesUrinary EGFLong-term kidney outcomesChronic kidney disease riskTRIBE-AKI (Translational Research Investigating Biomarker Endpoints for Acute Kidney Injury) ConsortiumKidney disease riskMCP-1 levelsRisk of CKDAmerican Heart AssociationPostoperative urine samplesHealth Research InstituteLong-term careCKD incidenceKidney outcomesKidney injuryKidney Precision Medicine ProjectComposite outcomeTubular damageHeart AssociationCCL2 expressionGlomerular functionKidney Center