2022
Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice
Spronck B, Ramachandra AB, Moriyama L, Toczek J, Han J, Sadeghi MM, Humphrey JD. Deletion of matrix metalloproteinase-12 compromises mechanical homeostasis and leads to an aged aortic phenotype in young mice. Journal Of Biomechanics 2022, 141: 111179. PMID: 35759974, PMCID: PMC9585962, DOI: 10.1016/j.jbiomech.2022.111179.Peer-Reviewed Original ResearchConceptsPulse wave velocityAortic phenotypeYoung miceAortic agingMMP-12Matrix metalloproteinasesMMP-12-deficient miceOld adult miceMatrix metalloproteinase-12Biomechanical propertiesAbdominal aortaArterial agingDeficient miceEnd organsBlood flowAdult miceCentral arteriesPercent changeMetalloproteinase-12MiceArterial wallAortaYoung adultsMatrix turnoverStrong proteolytic activity
2014
Imaging Vessel Wall Biology to Predict Outcome in Abdominal Aortic Aneurysm
Golestani R, Razavian M, Nie L, Zhang J, Jung JJ, Ye Y, de Roo M, Hilgerink K, Liu C, Robinson SP, Sadeghi MM. Imaging Vessel Wall Biology to Predict Outcome in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2014, 8: &na;. PMID: 25550400, PMCID: PMC4284949, DOI: 10.1161/circimaging.114.002471.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticAorta, AbdominalAortic Aneurysm, AbdominalAortic RuptureAortographyBiomarkersDisease Models, AnimalDisease ProgressionEnzyme ActivationFeasibility StudiesMaleMatrix MetalloproteinasesMice, Inbred C57BLMice, TransgenicMolecular ImagingMultimodal ImagingPredictive Value of TestsRadiopharmaceuticalsRisk AssessmentRisk FactorsTime FactorsTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMicro-single photon emissionAngiotensin IIMatrix metalloproteinasesAortic diameterSuprarenal aortaCD68 expressionMMP activityPotential of MMPSaline-infused miceVessel wall inflammationAbdominal aortic aneurysmPrediction of outcomePhoton emissionRupture riskMurine AAAsAortic expansionRisk stratificationWall inflammationAortic aneurysmSpontaneous ruptureSmall aneurysmsMouse modelControl animalsTracer uptakeAbdominal aortic aneurysm (AAA) rupture risk