2022
Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging.
Stendahl JC, Kwan JM, Pucar D, Sadeghi MM. Radiotracers to Address Unmet Clinical Needs in Cardiovascular Imaging, Part 1: Technical Considerations and Perfusion and Neuronal Imaging. Journal Of Nuclear Medicine 2022, 63: 649-658. PMID: 35487563, DOI: 10.2967/jnumed.121.263506.Peer-Reviewed Reviews, Practice Guidelines, Standards, and Consensus StatementsMeSH KeywordsAtherosclerosisHumansPerfusionPositron-Emission TomographyRadiopharmaceuticalsTomography, Emission-Computed, Single-PhotonConceptsUnmet diagnostic needsCardiovascular medicineNeuronal imagingImaging of inflammationHeart failureValvular diseaseTechnical considerationsDiagnostic needsCardiac amyloidosisUnmet ClinicalNew radiotracersCardiovascular imagingPersonalized therapyPerfusion tracerPET perfusion tracerThrombosisRadiotracer developmentRadiotracerPerfusionF-FlurpiridazImagingReviewMedicineKey technical considerationsMolecular characterization
2020
Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging
Gona K, Toczek J, Ye Y, Sanzida N, Golbazi A, Boodagh P, Salarian M, Jung JJ, Rajendran S, Kukreja G, Wu TL, Devel L, Sadeghi MM. Hydroxamate-Based Selective Macrophage Elastase (MMP-12) Inhibitors and Radiotracers for Molecular Imaging. Journal Of Medicinal Chemistry 2020, 63: 15037-15049. PMID: 33206510, PMCID: PMC8010999, DOI: 10.1021/acs.jmedchem.0c01514.Peer-Reviewed Original ResearchConceptsAbdominal aortic aneurysmMMP-12 inhibitorsSelective MMP-12 inhibitorMurine abdominal aortic aneurysmsRadiochemical stabilityFast blood clearanceMolecular imagingAortic aneurysmAAA progressionMMP-12Blood clearanceUpregulated MMPsAortic regionElastase inhibitorLead tracerNovel familyRupture riskMacrophage elastaseInhibitorsSelectivitySpecific bindingSynthesisVivo competitionImaging18F-Fluorodeoxyglucose PET imaging in aortic graft infection: many more questions than answers
Pucar D, Sadeghi MM. 18F-Fluorodeoxyglucose PET imaging in aortic graft infection: many more questions than answers. Journal Of Nuclear Cardiology 2020, 28: 1017-1020. PMID: 32607838, PMCID: PMC7772274, DOI: 10.1007/s12350-020-02248-4.Peer-Reviewed Original ResearchAccuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study
Toczek J, Wu J, Hillmer AT, Han J, Esterlis I, Cosgrove KP, Liu C, Sadeghi MM. Accuracy of arterial [18F]-Fluorodeoxyglucose uptake quantification: A kinetic modeling study. Journal Of Nuclear Cardiology 2020, 27: 1578-1581. PMID: 32043239, PMCID: PMC7415600, DOI: 10.1007/s12350-020-02055-x.Peer-Reviewed Original ResearchMeSH KeywordsAdultAortaFluorodeoxyglucose F18HumansMiddle AgedPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsConceptsMean SUVmaxMean TBRmaxFDG signalAortic wallMaximal standardized uptake valueD-glucose (FDG) PETVessel wall inflammationStandardized uptake valueActivity ex vivoPET imaging agentVascular inflammationWall inflammationRecent guidelinesBlood ratioCardiovascular diseasePrior historyPlasma activityTracer uptakeUptake valueSUVmaxTBRmaxEx vivoArterial wallVascular imagingFDG
2019
FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case–control study
Toczek J, Hillmer AT, Han J, Liu C, Peters D, Emami H, Wu J, Esterlis I, Cosgrove KP, Sadeghi MM. FDG PET imaging of vascular inflammation in post-traumatic stress disorder: A pilot case–control study. Journal Of Nuclear Cardiology 2019, 28: 688-694. PMID: 31073848, PMCID: PMC6842076, DOI: 10.1007/s12350-019-01724-w.Peer-Reviewed Original ResearchConceptsFDG-PET imagingPost-traumatic stress disorderFDG signalSystemic inflammationVascular inflammationCardiovascular diseaseBone marrowPET imagingFDG PET/CT imagingPilot case-control studyStress disorderCardiovascular risk factorsInflammatory biomarker levelsHealthy control subjectsPET/CT imagingCase-control studyPositron emission tomography (PET) imagingEmission Tomography ImagingInflammatory biomarkersControl subjectsBlood glucoseRisk factorsBiomarker levelsHealthy controlsProspective groupPET-Based Imaging of Ischemic Heart Disease
Chen K, Miller EJ, Sadeghi MM. PET-Based Imaging of Ischemic Heart Disease. PET Clinics 2019, 14: 211-221. PMID: 30826019, PMCID: PMC6426655, DOI: 10.1016/j.cpet.2018.12.003.Peer-Reviewed Original ResearchMeSH KeywordsComputed Tomography AngiographyCoronary Artery DiseaseCoronary CirculationCost-Benefit AnalysisFractional Flow Reserve, MyocardialHumansMultimodal ImagingMyocardial IschemiaMyocardial Perfusion ImagingPositron-Emission TomographyPrognosisRadiopharmaceuticalsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsIschemic heart diseaseHeart diseaseCoronary artery diseaseCardiac nuclear imagingCoronary flow reserveAtherosclerotic plaque vulnerabilityMyocardial blood flowCT myocardial perfusionArtery diseaseIschemic cardiomyopathyMicrovascular diseaseVascular calcificationFlow reserveVascular remodelingMyocardial viabilityPlaque vulnerabilityBlood flowMyocardial perfusionMolecular imaging toolDiseaseNuclear imagingImaging toolPETImagingPrognosis
2018
Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation
Ye Y, Toczek J, Gona K, Kim HY, Han J, Razavian M, Golestani R, Zhang J, Wu TL, Ghosh M, Jung JJ, Sadeghi MM. Novel Arginine-containing Macrocyclic MMP Inhibitors: Synthesis, 99mTc-labeling, and Evaluation. Scientific Reports 2018, 8: 11647. PMID: 30076321, PMCID: PMC6076275, DOI: 10.1038/s41598-018-29941-2.Peer-Reviewed Original ResearchConceptsMatrix metalloproteinasesMMP inhibitorsLung tissueTransgenic miceMMP activityHigh radiochemical purityHydroxamate MMP inhibitorsNumber of diseasesTissue remodelingSimilar inhibition potencyPotent inhibitionTherapySpecific bindingInhibitorsMolecular imagingImagingNovel arginineRadiochemical purityTissueHigh radiochemical yieldNew arginine
2016
Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation.
Tavakoli S, Short JD, Downs K, Nguyen HN, Lai Y, Zhang W, Jerabek P, Goins B, Sadeghi MM, Asmis R. Differential Regulation of Macrophage Glucose Metabolism by Macrophage Colony-stimulating Factor and Granulocyte-Macrophage Colony-stimulating Factor: Implications for 18F FDG PET Imaging of Vessel Wall Inflammation. Radiology 2016, 283: 87-97. PMID: 27849433, PMCID: PMC5375627, DOI: 10.1148/radiol.2016160839.Peer-Reviewed Original ResearchConceptsM-CSFMurine atherosclerotic aortasStable isotope tracingActivation stateExtracellular acidification rateGM-CSFMitochondrial biogenesisMacrophage colony-stimulating factorGlycolytic enzymesGlucose fluxMurine peritoneal macrophagesDistinct activation statesGlycolytic pathwayGlucose transporterCritical glycolytic enzymeGlycolytic metabolismAcidification rateIsotope tracingIntermediary metabolitesGlucose uptakeImmunometabolic phenotypeMurine atherosclerotic plaquesCell culturesSimilar levelsOxidative metabolism
2015
Molecular cardiovascular imaging is ready for prime time: almost there
Sadeghi MM. Molecular cardiovascular imaging is ready for prime time: almost there. Journal Of Nuclear Cardiology 2015, 23: 67-70. PMID: 26542993, DOI: 10.1007/s12350-015-0237-x.Peer-Reviewed Original Research18F-FDG PET and vascular inflammation: Time to refine the paradigm?
Sadeghi MM. 18F-FDG PET and vascular inflammation: Time to refine the paradigm? Journal Of Nuclear Cardiology 2015, 22: 319-324. PMID: 24925623, PMCID: PMC4265310, DOI: 10.1007/s12350-014-9917-1.Peer-Reviewed Original Research
2014
Imaging Vessel Wall Biology to Predict Outcome in Abdominal Aortic Aneurysm
Golestani R, Razavian M, Nie L, Zhang J, Jung JJ, Ye Y, de Roo M, Hilgerink K, Liu C, Robinson SP, Sadeghi MM. Imaging Vessel Wall Biology to Predict Outcome in Abdominal Aortic Aneurysm. Circulation Cardiovascular Imaging 2014, 8: &na;. PMID: 25550400, PMCID: PMC4284949, DOI: 10.1161/circimaging.114.002471.Peer-Reviewed Original ResearchMeSH KeywordsAngiotensin IIAnimalsAntigens, CDAntigens, Differentiation, MyelomonocyticAorta, AbdominalAortic Aneurysm, AbdominalAortic RuptureAortographyBiomarkersDisease Models, AnimalDisease ProgressionEnzyme ActivationFeasibility StudiesMaleMatrix MetalloproteinasesMice, Inbred C57BLMice, TransgenicMolecular ImagingMultimodal ImagingPredictive Value of TestsRadiopharmaceuticalsRisk AssessmentRisk FactorsTime FactorsTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsMicro-single photon emissionAngiotensin IIMatrix metalloproteinasesAortic diameterSuprarenal aortaCD68 expressionMMP activityPotential of MMPSaline-infused miceVessel wall inflammationAbdominal aortic aneurysmPrediction of outcomePhoton emissionRupture riskMurine AAAsAortic expansionRisk stratificationWall inflammationAortic aneurysmSpontaneous ruptureSmall aneurysmsMouse modelControl animalsTracer uptakeAbdominal aortic aneurysm (AAA) rupture riskMolecular imaging of plaque vulnerability
Tavakoli S, Vashist A, Sadeghi MM. Molecular imaging of plaque vulnerability. Journal Of Nuclear Cardiology 2014, 21: 1112-1128. PMID: 25124827, PMCID: PMC4229449, DOI: 10.1007/s12350-014-9959-4.Peer-Reviewed Original Research
2010
Molecular Imaging of Matrix Metalloproteinase Activation to Predict Murine Aneurysm Expansion In Vivo
Razavian M, Zhang J, Nie L, Tavakoli S, Razavian N, Dobrucki LW, Sinusas AJ, Edwards DS, Azure M, Sadeghi MM. Molecular Imaging of Matrix Metalloproteinase Activation to Predict Murine Aneurysm Expansion In Vivo. Journal Of Nuclear Medicine 2010, 51: 1107-1115. PMID: 20554725, PMCID: PMC2908304, DOI: 10.2967/jnumed.110.075259.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsApolipoproteins EArteriovenous FistulaAutoradiographyCarotid ArteriesCatalysisDisease ProgressionEnzyme ActivationImmunohistochemistryIndicators and ReagentsMatrix MetalloproteinasesMiceMice, KnockoutRadiopharmaceuticalsReverse Transcriptase Polymerase Chain ReactionSubstrate SpecificityTomography, Emission-ComputedTomography, Emission-Computed, Single-PhotonConceptsMatrix metalloproteinase activationMMP activationAneurysm inductionMetalloproteinase activationSPECT/CTCurrent imaging modalitiesPathogenesis of aneurysmsSpecific MMP inhibitorsGroups of animalsMMP tracerMolecular imagingArterial aneurysmsAneurysm expansionFocal uptakeDeficient miceCarotid aneurysmsCarotid arteryApolipoprotein ETracer uptakeAneurysmsMajor causeMMP inhibitorsVessel areaImaging modalitiesWk
2009
Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury.
Dobrucki LW, Meoli DF, Hu J, Sadeghi MM, Sinusas AJ. Regional hypoxia correlates with the uptake of a radiolabeled targeted marker of angiogenesis in rat model of myocardial hypertrophy and ischemic injury. Journal Of Physiology And Pharmacology 2009, 60 Suppl 4: 117-23. PMID: 20083860.Peer-Reviewed Original ResearchConceptsMyocardial hypertrophyHypoxic myocardiumMyocardial infarctionRat modelPressure overload-induced myocardial hypertrophyNon-invasive imaging strategyDeficient blood flowDegree of hypoperfusionAbdominal aortic bandingAnterior lateral wallLeft ventricular remodelingIschemic rat modelMarkers of angiogenesisHypoxia-induced angiogenesisPotential clinical useIschemic injuryAortic bandingVentricular remodelingAlphavbeta3 integrin receptorMyocardial hypoxiaImmunohistochemical stainingMyocardial uptakeRodent modelsBlood flowMyocardial segments
2008
Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction
Kalinowski L, Dobrucki LW, Meoli DF, Dione DP, Sadeghi MM, Madri JA, Sinusas AJ. Targeted imaging of hypoxia-induced integrin activation in myocardium early after infarction. Journal Of Applied Physiology 2008, 104: 1504-1512. PMID: 18356482, DOI: 10.1152/japplphysiol.00861.2007.Peer-Reviewed Original ResearchMeSH KeywordsActinsAnimalsBiomarkersBiotransformationDogsHeterocyclic Compounds, 1-RingHypoxiaImidazolesImmunohistochemistryIntegrin alphaVbeta3IntegrinsMaleMyocardial InfarctionMyocardial IschemiaMyocardiumNeovascularization, PhysiologicOrganometallic CompoundsOrganotechnetium CompoundsRadiopharmaceuticalsRatsRats, Sprague-DawleyTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonConceptsMyocardial infarctionInfarct regionCanine studyIschemic heart diseaseCoronary artery occlusionAcute myocardial infarctionMarkers of angiogenesisEx vivo analysisExpression/activationPotential novel targetHypoxia-induced angiogenesisVivo SPECT imagingAlphavbeta3 integrinBRU59-21Artery occlusionNovel noninvasive approachHeart diseaseHistological evidenceMyocardial hypoxiaMyocardial uptakeRP748Rodent studiesAngiogenic therapyInfarctionMyocardial angiogenesis
2005
Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models
Piao D, Sadeghi MM, Zhang J, Chen Y, Sinusas AJ, Zhu Q. Hybrid positron detection and optical coherence tomography system: design, calibration, and experimental validation with rabbit atherosclerotic models. Journal Of Biomedical Optics 2005, 10: 044010-044010-10. PMID: 16178644, DOI: 10.1117/1.1954773.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisCalibrationCatheters, IndwellingDisease Models, AnimalEquipment DesignEquipment Failure AnalysisFluorodeoxyglucose F18Image EnhancementPositron-Emission TomographyRabbitsRadionuclide ImagingRadiopharmaceuticalsSubtraction TechniqueSystems IntegrationTomography, Optical CoherenceTransducers
2004
Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction
Meoli DF, Sadeghi MM, Krassilnikova S, Bourke BN, Giordano FJ, Dione DP, Su H, Edwards DS, Liu S, Harris TD, Madri JA, Zaret BL, Sinusas AJ. Noninvasive imaging of myocardial angiogenesis following experimental myocardial infarction. Journal Of Clinical Investigation 2004, 113: 1684-1691. PMID: 15199403, PMCID: PMC420502, DOI: 10.1172/jci20352.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsCells, CulturedCoronary VesselsDiagnostic ImagingDogsEndothelial CellsEndothelium, VascularHemodynamicsIndium RadioisotopesIntegrin alphaVbeta3MaleMolecular StructureMyocardial InfarctionMyocardiumNeovascularization, PhysiologicQuinolonesRadiopharmaceuticalsRatsRats, Sprague-DawleyTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonConceptsMyocardial angiogenesisMyocardial infarctionRadiotracer uptakeInjury-induced angiogenesisChronic rat modelNoninvasive imaging strategiesTherapeutic myocardial angiogenesisExperimental myocardial infarctionFocal radiotracer uptakePotential novel targetSignificant clinical utilityAlphavbeta3 integrinRisk stratificationHistological evidenceHypoperfused regionsRat modelMyocardial radiotracer uptakeClinical utilityNoninvasive evaluationAngiogenic therapyCanine modelInfarct regionInfarctionNovel targetNoninvasive imaging