2013
Lipid lowering and imaging protease activation in atherosclerosis
Razavian M, Nie L, Challa A, Zhang J, Golestani R, Jung JJ, Robinson S, Sadeghi MM. Lipid lowering and imaging protease activation in atherosclerosis. Journal Of Nuclear Cardiology 2013, 21: 319-328. PMID: 24368425, PMCID: PMC3991560, DOI: 10.1007/s12350-013-9843-7.Peer-Reviewed Original ResearchConceptsHigh-fat dietLipid-lowering interventionsHFD groupPlaque inflammationAtherosclerotic miceMicroSPECT/CT imagingTotal blood cholesterolModern therapeutic approachesSmooth muscle αMMP tracerFat dietBlood cholesterolPlaque biologyTherapeutic approachesTracer uptakeMatrix metalloproteinaseTherapeutic interventionsAtherosclerosisActin expressionCT imagingMuscle αWeeksFenofibrateMiceIntervention
2010
Imaging Atherosclerosis and Vulnerable Plaque
Sadeghi MM, Glover DK, Lanza GM, Fayad ZA, Johnson LL. Imaging Atherosclerosis and Vulnerable Plaque. Journal Of Nuclear Medicine 2010, 51: 51s-65s. PMID: 20395341, PMCID: PMC2911776, DOI: 10.2967/jnumed.109.068163.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAtherosclerosisClinical Trials as TopicContrast MediaExtracellular MatrixFerric CompoundsFluorodeoxyglucose F18HumansInflammationMagnetic Resonance ImagingNanoparticlesNeovascularization, PathologicRiskThrombosisTomography, Emission-Computed, Single-PhotonTomography, X-Ray ComputedConceptsTotal atherosclerotic burdenAcute cardiovascular eventsAtherosclerotic burdenCardiovascular eventsVascular thrombosisPlaque inflammationMyocardial infarctionPlaque stabilityFibrin depositsVulnerable plaquesHigh riskVasa vasorumPlaque evolutionSame imaging sessionVascular imagingVessel wallImaging sessionClinical translationBiologic processesModalitiesAnatomyExtracellular matrix