2024
Abstract 3015: Matrix Metalloproteinase Inhibition In Rat Abdominal Aortic Aneurysm
Zaghloul M, Elizondo-Benedetto S, Arif B, Heo G, Luehmann H, Liu Y, Gropler R, Sadeghi M, Zayed M. Abstract 3015: Matrix Metalloproteinase Inhibition In Rat Abdominal Aortic Aneurysm. Arteriosclerosis Thrombosis And Vascular Biology 2024, 44 DOI: 10.1161/atvb.44.suppl_1.3015.Peer-Reviewed Original ResearchAbdominal aortic aneurysmPostoperative day 3Rupture of abdominal aortic aneurysmsTreated ratsInhibition of matrix metalloproteinasesMatrix metalloproteinase inhibitionMatrix metalloproteinase inhibitorsMatrix metalloproteinasesAortic aneurysmRat modelAbdominal aortic aneurysm diameterUntreated groupMale Sprague-Dawley ratsAbdominal aortic aneurysm rupture rateSprague-Dawley ratsAortic diameter measurementsActive MMP-9Rate of ruptureDegradation of extracellular matrix proteinsAbdominal aortic aneurysm researchIL-17ARadiotracer uptakeUntreated ratsTNF-aIL-1B
2016
Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice
Jung JJ, Razavian M, Kim HY, Ye Y, Golestani R, Toczek J, Zhang J, Sadeghi MM. Matrix metalloproteinase inhibitor, doxycycline and progression of calcific aortic valve disease in hyperlipidemic mice. Scientific Reports 2016, 6: 32659. PMID: 27619752, PMCID: PMC5020643, DOI: 10.1038/srep32659.Peer-Reviewed Original ResearchConceptsCalcific aortic valve diseaseAortic valve diseaseEffect of doxycyclineWestern dietCAVD progressionMatrix metalloproteinasesValve diseaseMicro-single photon emissionNonselective MMP inhibitorTherapeutic blood levelsLack of effectSingle photon emissionMatrix metalloproteinase inhibitorsGroups of animalsAortic stenosisMedical therapyHyperlipidemic miceEarly diseaseBlood levelsCommon causeTissue analysisMMP activationMMP inhibitionGelatinase activityDoxycycline