Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium
Dunaway L, Luse M, Nyshadham S, Bulut G, Alencar G, Chavkin N, Cortese-Krott M, Hirschi K, Isakson B. Obesogenic diet disrupts tissue-specific mitochondrial gene signatures in the artery and capillary endothelium. Physiological Genomics 2023, 56: 113-127. PMID: 37982169, PMCID: PMC11281809, DOI: 10.1152/physiolgenomics.00109.2023.Peer-Reviewed Original ResearchConceptsSingle-cell RNA sequencingMitochondrial gene expressionGene expressionRNA sequencingOxidative phosphorylation gene expressionHigh-fat dietTranscription factor analysisSingle-nucleus RNAEndothelial cellsCapillary endothelial cellsAdipose endothelial cellsMitochondrial genesPhenotypic convergenceMesenteric endothelial cellsTranscriptional phenotypeBulk RNALipid homeostasisPeroxisome proliferator-activated receptorDistinct rolesPhenotypic shiftNovel mechanismMouse AdiposeProliferator-activated receptorResident tissuesDownregulation of PPAR