Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure
Horitani K, Chavkin N, Arai Y, Wang Y, Ogawa H, Yura Y, Evans M, Cochran J, Thel M, Polizio A, Sano M, Miura-Yura E, Arai Y, Doviak H, Arnold A, Gelfand B, Hirschi K, Sano S, Walsh K. Disruption of the Uty epigenetic regulator locus in hematopoietic cells phenocopies the profibrotic attributes of Y chromosome loss in heart failure. Nature Cardiovascular Research 2024, 3: 343-355. PMID: 39183958, PMCID: PMC11343478, DOI: 10.1038/s44161-024-00441-z.Peer-Reviewed Original ResearchHeart failureHigher incidence of heart failureHigher incidenceProgression of heart failureIncidence of heart failureY chromosome lossCardiac fibroblast activationProfibrotic macrophagesDilated cardiomyopathyHematopoietic cellsMale miceFailing heartIncreased riskEpigenetic alterationsFibroblast activationMosaic lossLeukocytesUTIMacrophagesHearts of humansAccelerated progressionRegulator locusHeartGene expressionY chromosome