Endothelial-adipocyte Cx43 mediated gap junctions can regulate adiposity
Luse M, Dunaway L, Nyshadham S, Carvalho A, Sedovy M, Ruddiman C, Tessema R, Hirschi K, Johnstone S, Isakson B. Endothelial-adipocyte Cx43 mediated gap junctions can regulate adiposity. Function 2024, zqae029. PMID: 38984993, DOI: 10.1093/function/zqae029.Peer-Reviewed Original ResearchHigh-fat dietHigh-fat diet miceGap junctionsIncreased risk of cardiovascular diseaseUpregulation of fatty acid-binding protein 4Co-culture transwell systemPhosphorylation of Cx43Adipose endothelial cellsRisk of cardiovascular diseaseImproved lipid profileFatty acid binding protein 4Endothelial Cx43Adipocytes in vitroAdipose tissue functionBinding protein 4Post-translational modificationsEpididymal fat padsHeterocellular contactsSingle-cell RNA sequencingEndothelial dysfunctionSerine 368Cx43Heterocellular communicationLipid profileGenetic deletion