Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia
Genet G, Genet N, Paila U, Cain S, Cwiek A, Chavkin N, Serbulea V, Figueras A, Cerdà P, McDonnell S, Sankaranarayanan D, Huba M, Nelson E, Riera-Mestre A, Hirschi K. Induced Endothelial Cell Cycle Arrest Prevents Arteriovenous Malformations in Hereditary Hemorrhagic Telangiectasia. Circulation 2023, 149: 944-962. PMID: 38126211, PMCID: PMC10954087, DOI: 10.1161/circulationaha.122.062952.Peer-Reviewed Original ResearchHereditary hemorrhagic telangiectasiaArteriovenous malformationsVascular malformationsHemorrhagic telangiectasiaCDK 4/6 inhibitor palbociclibCell cycle G1 arrestCell cycle stateG1 arrestEndothelial-specific deletionInhibitor palbociclibLate G1 arrestPalbociclib treatmentArteriovenous shuntsDrug AdministrationTherapeutic potentialGenetic deletionType 1Cell cycle controlEndothelial cell cycleMalformationsArteriovenous identityEndothelial cell migrationAVM developmentPalbociclibCycle control