Featured Publications
2-Year Outcomes After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients
Forrest JK, Deeb GM, Yakubov SJ, Rovin JD, Mumtaz M, Gada H, O'Hair D, Bajwa T, Sorajja P, Heiser JC, Merhi W, Mangi A, Spriggs DJ, Kleiman NS, Chetcuti SJ, Teirstein PS, Zorn GL, Tadros P, Tchétché D, Resar JR, Walton A, Gleason TG, Ramlawi B, Iskander A, Caputo R, Oh JK, Huang J, Reardon MJ. 2-Year Outcomes After Transcatheter Versus Surgical Aortic Valve Replacement in Low-Risk Patients. Journal Of The American College Of Cardiology 2022, 79: 882-896. PMID: 35241222, DOI: 10.1016/j.jacc.2021.11.062.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementEvolut Low Risk trialLow-risk trialsAortic valve replacementPrimary endpointRisk trialsCause mortalityValve replacementTranscatheter Versus Surgical Aortic Valve ReplacementLow surgical risk patientsSurgical aortic valve replacementIndependent clinical events committeeEchocardiographic core laboratoryKaplan-Meier ratesSevere aortic stenosisClinical events committeeLow-risk patientsCause mortality ratesSelf-expanding valvesDisabling strokeEchocardiographic outcomesSurgical AVRTAVR groupSurgery groupAdverse eventsTranscatheter Aortic Valve Replacement in Low-risk Patients With Bicuspid Aortic Valve Stenosis
Forrest JK, Ramlawi B, Deeb GM, Zahr F, Song HK, Kleiman NS, Chetcuti SJ, Michelena HI, Mangi AA, Skiles JA, Huang J, Popma JJ, Reardon MJ. Transcatheter Aortic Valve Replacement in Low-risk Patients With Bicuspid Aortic Valve Stenosis. JAMA Cardiology 2020, 6: 50-57. PMID: 33031491, PMCID: PMC7542521, DOI: 10.1001/jamacardio.2020.4738.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementBicuspid aortic valve stenosisAortic valve replacementAortic valve stenosisLow-risk patientsDevice success rateValve replacementValve stenosisCause mortalityRandomized trialsAmerican Heart Association/American CollegeSevere bicuspid aortic valve stenosisHigh device success rateLow surgical risk patientsPrespecified primary end pointPrimary efficacy end pointEnd pointBicuspid aortic stenosisMean AV gradientThoracic Surgeons scoreEfficacy end pointPrimary end pointLow surgical riskMild paravalvular leakNew permanent pacemakerTranscatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valves From the STS/ACC TVT Registry
Forrest JK, Kaple RK, Ramlawi B, Gleason TG, Meduri CU, Yakubov SJ, Jilaihawi H, Liu F, Reardon MJ. Transcatheter Aortic Valve Replacement in Bicuspid Versus Tricuspid Aortic Valves From the STS/ACC TVT Registry. JACC Cardiovascular Interventions 2020, 13: 1749-1759. PMID: 32473890, DOI: 10.1016/j.jcin.2020.03.022.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic Valve StenosisBicuspid Aortic Valve DiseaseFemaleHeart Valve ProsthesisHemodynamicsHumansMaleMiddle AgedPostoperative ComplicationsProsthesis DesignRecovery of FunctionRegistriesRetrospective StudiesRisk AssessmentRisk FactorsTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeUnited StatesConceptsAortic valve stenosisBicuspid aortic valve stenosisTranscatheter aortic valve replacementEvolut PRO valveAortic valve replacementValve stenosisTVT RegistryCause mortalityValve replacementEvolut RBicuspid valveBicuspid Versus Tricuspid Aortic ValvesSTS/ACC TVT RegistryThoracic Surgeons/American CollegeTricuspid aortic valve stenosisCardiology TVT (Transcatheter Valve Therapy) RegistryTricuspid aortic stenosisRate of strokeSelf-expanding valvesLow complication rateTricuspid aortic valveAcceptable safety outcomesCardiac comorbiditiesEchocardiographic outcomesAortic stenosisPropensity-Matched Outcomes Comparing TAVR in Bicuspid vs Surgery in Tricuspid Aortic Valve Stenosis
Deeb G, Yakubov S, Reardon M, Ramlawi B, Chetcuti S, Kleiman N, Zahr F, Song H, Gada H, Mumtaz M, Ito S, Huang J, Forrest J. Propensity-Matched Outcomes Comparing TAVR in Bicuspid vs Surgery in Tricuspid Aortic Valve Stenosis. Journal Of The Society For Cardiovascular Angiography & Interventions 2023, 2: 100525. DOI: 10.1016/j.jscai.2022.100525.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementSurgical aortic valve replacementAortic valve stenosisTricuspid aortic valve stenosisBicuspid aortic valve stenosisAortic valve replacementSAVR patientsValve replacementValve stenosisEvolut Low Risk trialIndependent clinical events committeeLow-risk trialsSerious adverse eventsSevere aortic regurgitationClinical events committeeLow surgical riskLow-risk patientsIndependent core laboratoryEffective orifice areaTAVR groupValve gradientAdverse eventsAortic regurgitationSurgical riskEvents committee3-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis
Forrest J, Deeb G, Yakubov S, Gada H, Mumtaz M, Ramlawi B, Bajwa T, Teirstein P, DeFrain M, Muppala M, Rutkin B, Chawla A, Jenson B, Chetcuti S, Stoler R, Poulin M, Khabbaz K, Levack M, Goel K, Tchétché D, Lam K, Tonino P, Ito S, Oh J, Huang J, Popma J, Kleiman N, Reardon M, Investigators L, Sorajja P, Byrne T, Kirshner M, Bajwa T, Crouch J, Coselli J, Silva G, Hebeler R, Stoler R, Islam A, Rousou A, Poulin M, Khabbaz K, Bladergroen M, Fail P, Netherland D, Lam K, Tonino W, Sudre A, Berthoumieu P, Tchétché D, Khalili H, Hughes G, Harrison J, De A, Tsau P, van Mieghem N, Larbalestier R, Yong G, Agarwal S, Martin W, Park S, Kleiman N, Reardon M, Mohammadi S, Rodes-Cabau J, Sparling J, Elkins C, Ganzel B, Matthews R, Starnes V, Ando K, Chevalier B, Farge A, DeFrain M, Muppala M, Combs W, Bagur R, Chu M, Fontana G, Dev V, Leya F, Tuchek J, Inglessis I, Jassar A, Piazza N, Lacappelle K, Steinberg D, Katz M, Wang J, Kozina J, Slachman F, Merritt R, Chawla A, Jensen B, Alvarez J, Gooley R, Smith J, Ibrahim R, Cartier R, Rovin J, Fujita T, Rutkin B, Yakubov S, Song H, Zahr F, Miyagawa S, Rajagopal V, Kauten J, Gada H, Mumtaz M, Bhindi R, Brady P, Batra S, Davis T, Iskander A, Heimansohn D, Hermiller J, Takamisawa I, Haldis T, Yamazaki S, Teirstein P, Tada N, Saito S, Merhi W, Leung S, Muller D, Heijmen R, Petrossian G, Robinson N, Knight P, Ling F, Radhakrishnan S, Fremes S, Lehr E, Gafoor S, Noel T, Walton A, Resar J, Adams D, Sharma S, Lilly S, Tadros P, Zorn G, Dauerman H, Ittleman F, Horlick E, Feindel C, Welt F, Sharma V, Markowitz A, Carroll J, Fullerton D, Griffith B, Gupta A, de Marchena E, Salerno T, Chetcuti S, Deeb G, Sultan I, Goel K, Pasupati S, Kon N, Zhao D, Ramlawi B, Forrest J. 3-Year Outcomes After Transcatheter or Surgical Aortic Valve Replacement in Low-Risk Patients With Aortic Stenosis. Journal Of The American College Of Cardiology 2023, 81: 1663-1674. PMID: 36882136, DOI: 10.1016/j.jacc.2023.02.017.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementLow-risk patientsCause mortalityPrimary endpointParavalvular regurgitationValve replacementEvolut Low Risk trialLow surgical risk patientsSurgical aortic valve replacementGreater paravalvular regurgitationLow-risk trialsData comparing outcomesLow-risk studiesSupra-annular valveEchocardiographic outcomesSecondary endpointsSurgery groupTAVR patientsRisk patientsSurgery patientsAortic stenosisPacemaker placementTreatment armsMean age
2024
Four-Year Outcomes After Transcatheter or Contemporary Surgical Aortic Valve Replacement from the Evolut Low Risk Trial
Ramlawi B, Deeb G, Mumtaz M, Bajwa T, Rovin J, Yakubov S, Jung Y, Reardon M, Forrest J. Four-Year Outcomes After Transcatheter or Contemporary Surgical Aortic Valve Replacement from the Evolut Low Risk Trial. Journal Of Thoracic And Cardiovascular Surgery 2024 PMID: 39181441, DOI: 10.1016/j.jtcvs.2024.08.023.Peer-Reviewed Original ResearchTranscatheter or Surgical Aortic Valve Replacement in Women With Small Annuli at Low or Intermediate Surgical Risk
Modine T, Forrest J, Van Mieghem N, Deeb G, Yakubov S, Ali W, Tchétché D, Lam K, Oh J, Huang J, Mehran R, Reardon M. Transcatheter or Surgical Aortic Valve Replacement in Women With Small Annuli at Low or Intermediate Surgical Risk. The American Journal Of Cardiology 2024, 223: 147-155. PMID: 38641189, DOI: 10.1016/j.amjcard.2024.04.013.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementAortic valve replacementIntermediate surgical riskValve replacementSurgical riskAortic stenosisTranscatheter aortic valve replacement groupImpact of transcatheter aortic valve replacementSurgical aortic valve replacementMid-term clinical outcomesPatient-prothesis mismatchSmall aortic annulusMidterm clinical outcomesSevere aortic stenosisSelf-expandingEffective orifice areaAll-cause mortalityEvaluated 2 yearsPost hoc analysisRandomized controlled trialsAortic annulusSurgical groupPrimary endpointHemodynamic outcomesClinical outcomesReinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis
Grubb K, Lisko J, O'Hair D, Merhi W, Forrest J, Mahoney P, Van Mieghem N, Windecker S, Yakubov S, Williams M, Chetcuti S, Deeb G, Kleiman N, Althouse A, Reardon M. Reinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis. JACC Cardiovascular Interventions 2024, 17: 1007-1016. PMID: 38573257, DOI: 10.1016/j.jcin.2024.01.292.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overAortic ValveAortic Valve StenosisFemaleHeart Valve ProsthesisHeart Valve Prosthesis ImplantationHumansIncidenceMalePostoperative ComplicationsProsthesis DesignRandomized Controlled Trials as TopicRetreatmentRisk AssessmentRisk FactorsSeverity of Illness IndexTime FactorsTranscatheter Aortic Valve ReplacementTreatment OutcomeConceptsSurgical aortic valve replacementTranscatheter aortic valve replacementIncidence of reinterventionAortic valve replacementCumulative incidence of reinterventionValve replacementValve reinterventionCumulative incidenceCoreValve transcatheter aortic valve replacementLow incidence of reinterventionSurgical aortic valve replacement patientsSingle-arm studyFirst-generation CoreValveEvolut R/ProParavalvular regurgitationReinterventionRandomized trialsLow incidenceCoreValvePooled dataTranscatheterIncidenceTreatmentYearsEndocarditisRacial/Ethnic Disparities in Aortic Valve Replacement Among Medicare Beneficiaries in the United States, 2012-2019
Gupta A, Mori M, Wang Y, Pawar S, Vahl T, Nazif T, Onuma O, Yong C, Sharma R, Kirtane A, Forrest J, George I, Kodali S, Chikwe J, Geirsson A, Makkar R, Leon M, Krumholz H. Racial/Ethnic Disparities in Aortic Valve Replacement Among Medicare Beneficiaries in the United States, 2012-2019. The American Journal Of Medicine 2024, 137: 321-330.e7. PMID: 38190959, PMCID: PMC11019903, DOI: 10.1016/j.amjmed.2023.12.026.Peer-Reviewed Original ResearchAortic valve replacementRace/ethnicityValve replacementAortic stenosisWhite patientsMedicare beneficiariesSurgical aortic valve replacement (SAVR) proceduresCross-sectional cohort studyAortic valve replacement proceduresAortic stenosis treatmentRacial/Ethnic DisparitiesValve replacement proceduresSelf-reported race/ethnicityRace-related differencesIndex admissionIndex hospitalizationCohort studyAsian patientsPrincipal diagnosisProcedural outcomesStenosis treatmentCare spectrumPatientsEthnic disparitiesStenosis
2023
Feasibility of Coronary Access Following Redo-TAVR for Evolut Failure: A Computed Tomography Simulation Study
Tang G, Spencer J, Rogers T, Grubb K, Gleason P, Gada H, Mahoney P, Dauerman H, Forrest J, Reardon M, Blanke P, Leipsic J, Abdel-Wahab M, Attizzani G, Puri R, Caskey M, Chung C, Chen Y, Dudek D, Allen K, Chhatriwalla A, Htun W, Blackman D, Tarantini G, Sanchez J, Schwartz G, Popma J, Sathananthan J. Feasibility of Coronary Access Following Redo-TAVR for Evolut Failure: A Computed Tomography Simulation Study. Circulation Cardiovascular Interventions 2023, 16: e013238. PMID: 37988439, PMCID: PMC10653288, DOI: 10.1161/circinterventions.123.013238.Peer-Reviewed Original ResearchConceptsRedo-TAVRSAPIEN 3Coronary accessRedo transcatheter aortic valve replacementYounger low-risk patientsFuture coronary accessSAPIEN 3 valveAortic valve replacementLow-risk patientsSelf-expanding valvesPre-TAVR CTValve replacementValve implantationCT planningEvolutImplant positionTomography imagingPatientsCTNodes 4Implant depthTAVRSubstudyNodes 5ValveTCT-133 Reinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis
Grubb K, Lisko J, O’Hair D, Merhi W, Forrest J, Mahoney P, van Mieghem N, Windecker S, Yakubov S, Chetcuti S, Deeb G, Kleiman N, Althouse A, Reardon M. TCT-133 Reinterventions After CoreValve/Evolut Transcatheter or Surgical Aortic Valve Replacement for Treatment of Severe Aortic Stenosis. Journal Of The American College Of Cardiology 2023, 82: b52. DOI: 10.1016/j.jacc.2023.09.139.Peer-Reviewed Original ResearchEffect of antecedent statin usage on conduction disturbances and arrhythmias after transcatheter aortic valve replacement
Shah T, Maarek R, See C, Huang H, Wang Y, Parise H, Forrest J, Lansky A. Effect of antecedent statin usage on conduction disturbances and arrhythmias after transcatheter aortic valve replacement. Cardiovascular Revascularization Medicine 2023, 59: 3-8. PMID: 37573173, DOI: 10.1016/j.carrev.2023.07.022.Peer-Reviewed Original ResearchConceptsAtrial fibrillationConduction disturbancesPrimary endpointStatin usersPacemaker placementRate of AFTranscatheter aortic valve replacementNew atrial fibrillationNew conduction disturbancesPersistent conduction disturbancesAortic valve replacementLong-term prognosisSmall retrospective studiesSignificant differencesPrior pacemakerIndex hospitalizationIntensity statinsValve replacementConsecutive patientsPropensity matchingProcedural complicationsStatin regimenRetrospective studyStatin usageCardiac proceduresImpact of New-Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single-Center Study
See C, Wang Y, Huang H, Parise H, Yang Y, Tirziu D, Francese D, Papoutsidakis N, Bader E, Kaple R, Cleman M, Lansky A, Forrest J. Impact of New-Onset Conduction Disturbances following Transcatheter Aortic Valve Replacement on Outcomes: A Single-Center Study. Journal Of Interventional Cardiology 2023, 2023: 5390338. PMID: 37292113, PMCID: PMC10247319, DOI: 10.1155/2023/5390338.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementNew-onset conduction disturbancesAortic valve replacementPersistent conduction disturbancesConduction disturbancesValve replacementSurgical aortic valve replacementSingle-center retrospective analysisYale-New Haven HospitalSingle-center studyCause mortality ratesCause mortality riskLong-term outcomesNew Haven HospitalPeriprocedural factorsAortic stenosisConsecutive patientsTAVR proceduresTerm outcomesRetrospective analysisMortality riskMortality ratePatientsOutcomesPatient's ECGImpact of aortic valve replacement in symptomatic low-risk patients with less than severe aortic stenosis
Ito S, Laham R, Nkomo V, Forrest J, Reardon M, Little S, Mumtaz M, Gada H, Bajwa T, Langholz D, Heiser J, Chawla A, Jenson B, Attizanni G, Markowitz A, Huang J, Oh J. Impact of aortic valve replacement in symptomatic low-risk patients with less than severe aortic stenosis. Open Heart 2023, 10: e002297. PMID: 37173100, PMCID: PMC10186477, DOI: 10.1136/openhrt-2023-002297.Peer-Reviewed Original ResearchConceptsSevere aortic stenosisAortic valve replacementAortic stenosisSymptomatic patientsValve replacementKansas City Cardiomyopathy Questionnaire overall summary scoreEvolut Low Risk trialSurgical aortic valve replacementLow-risk trialsLow-risk patientsOverall summary scoreRate of deathQuality of lifeDisabling strokeEchocardiographic evidenceIsolated AVRHaemodynamic profileClinical outcomesHaemodynamic outcomesRisk trialsClinical trialsCalcium volumeSummary scoresPatientsCore laboratory measurementsCerebral Embolic Protection in Transcatheter Aortic Valve Replacement
Iskander M, Jamil Y, Forrest J, Madhavan M, Makkar R, Leon M, Lansky A, Ahmad Y. Cerebral Embolic Protection in Transcatheter Aortic Valve Replacement. Structural Heart 2023, 7: 100169. PMID: 37520138, PMCID: PMC10382985, DOI: 10.1016/j.shj.2023.100169.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementCerebral embolic protection devicesCerebral embolic protectionAortic valve replacementEmbolic protection devicesValve replacementEmbolic protectionSymptomatic severe aortic stenosisSevere aortic stenosisLow-risk patientsPredictors of strokeOccurrence of complicationsRisk of strokeRecent trial dataRelevant clinical studiesOverall evidence baseExpansion of TAVRFeared complicationAortic stenosisSurgical riskTreatment optionsWorse outcomesClinical studiesPatientsTrial dataTranscatheter Aortic Valve Replacement in Large Annuli Valves With the Supra-Annular, Self-Expandable Evolut Platform in a Real-World Registry
Dallan L, Tang G, Forrest J, Reardon M, Szeto W, Kodali S, Baeza C, Eisenberg R, Attizzani G. Transcatheter Aortic Valve Replacement in Large Annuli Valves With the Supra-Annular, Self-Expandable Evolut Platform in a Real-World Registry. Circulation Cardiovascular Interventions 2023, 16: e012623. PMID: 36943929, PMCID: PMC10022658, DOI: 10.1161/circinterventions.122.012623.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementAortic valve replacementCardiology Transcatheter Valve Therapy RegistryThoracic Surgeons/American CollegeTranscatheter Valve Therapy RegistryValve replacementAortic stenosisAmerican CollegeMultivariable Cox proportional hazards regression modelsAnnulus sizeCox proportional hazards regression modelProportional hazards regression modelsAortic valve reinterventionTricuspid aortic stenosisReal-world registrySevere aortic stenosisBetter clinical outcomesTreatment of patientsHazards regression modelsComputed tomography angiographyLarge annulusValve reinterventionCause mortalityReadmission ratesValve proceduresTranscatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials
Ahmad Y, Howard J, Arnold A, Madhavan M, Cook C, Alu M, Mack M, Reardon M, Thourani V, Kapadia S, Thyregod H, Sondergaard L, Jørgensen T, Toff W, Van Mieghem N, Makkar R, Forrest J, Leon M. Transcatheter versus surgical aortic valve replacement in lower-risk and higher-risk patients: a meta-analysis of randomized trials. European Heart Journal 2023, 44: 836-852. PMID: 36660821, DOI: 10.1093/eurheartj/ehac642.Peer-Reviewed Original ResearchConceptsSurgical aortic valve replacementTranscatheter aortic valve implantationHigh-risk patientsLow-risk patientsComposite of deathAortic valve replacementValve replacementMAIN OUTCOMENew-onset atrial fibrillationSignificant differencesRandomized clinical trial dataAcute kidney injuryAortic valve implantationMain clinical outcomesRisk of deathClinical trial dataMajor bleedingKidney injurySecondary endpointsVascular complicationsValve implantationClinical outcomesParavalvular leakRandomized trialsAtrial fibrillation
2022
Clinical Research on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Disease: Principles, Challenges, and an Agenda for the Future
Ahmad Y, Madhavan M, Baron S, Forrest J, Borger M, Leipsic J, Cavalcante J, Wang D, McCarthy P, Szerlip M, Kapadia S, Makkar R, Mack M, Leon M, Cohen D. Clinical Research on Transcatheter Aortic Valve Replacement for Bicuspid Aortic Valve Disease: Principles, Challenges, and an Agenda for the Future. Structural Heart 2022, 7: 100102. PMID: 37275317, PMCID: PMC10236801, DOI: 10.1016/j.shj.2022.100102.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementBicuspid aortic valve diseaseSurgical aortic valve replacementAortic valve replacementAortic valve diseaseValve replacementClinical researchValve diseaseValvular heart diseaseDesign of RCTsProcedural therapiesProspective registryHeart diseaseExclusion criteriaRisk scorePatientsRCTsDiseaseCardiovascular communityMultidisciplinary workshopSelection biasTrialsInternational expertsPotential studiesRegistryReadmission rates and risk factors for readmission after transcatheter aortic valve replacement in patients with end-stage renal disease
Park DY, An S, Hanna JM, Wang SY, Cruz-Solbes AS, Kochar A, Lowenstern AM, Forrest JK, Ahmad Y, Cleman M, Al Damluji A, Nanna MG. Readmission rates and risk factors for readmission after transcatheter aortic valve replacement in patients with end-stage renal disease. PLOS ONE 2022, 17: e0276394. PMID: 36264931, PMCID: PMC9584363, DOI: 10.1371/journal.pone.0276394.Peer-Reviewed Original ResearchConceptsEnd-stage renal diseaseTranscatheter aortic valve replacementLength of stayAortic valve replacementIndex hospitalizationHospital mortalityReadmission ratesValve replacementRenal diseaseLonger LOSNational Readmission DatabaseRisk of readmissionChronic pulmonary diseaseMultivariable logistic regressionCardiovascular causesCardiovascular readmissionCause readmissionHospital readmissionPulmonary diseaseHospital chargesPoor outcomeRisk factorsHospital costsReadmissionHigher oddsSite-Level Variation and Predictors of Permanent Pacemaker Implantation Following TAVR in the Evolut Low-Risk Trial
Gada H, Vora AN, Tang GHL, Mumtaz M, Forrest JK, Laham RJ, Yakubov SJ, Deeb GM, Rammohan C, Huang J, Reardon MJ. Site-Level Variation and Predictors of Permanent Pacemaker Implantation Following TAVR in the Evolut Low-Risk Trial. Cardiovascular Revascularization Medicine 2022, 47: 48-54. PMID: 36266154, DOI: 10.1016/j.carrev.2022.10.004.Peer-Reviewed Original ResearchConceptsTranscatheter aortic valve replacementPermanent pacemaker implantationNew permanent pacemaker implantationAortic valve replacementPPI rateValve replacementPacemaker implantationClinical outcomesBenefits of TAVRSelf-expanding transcatheter aortic valve replacementBaseline right bundle branch blockRate of PPIEvolut Low Risk trialSurgical aortic valve replacementRight bundle branch blockLow-risk trialsLeft coronary sinusLow-risk patientsBundle branch blockEvolut valvesCoronary sinusGeneral anesthesiaConduction disordersBranch blockProcedural characteristics