2025
Novel Hemodynamic Markers and Kidney Function in Patients with Acute Decompensated Heart Failure
Tuttle M, Banlengchit R, Tighiouart H, Testani J, Moises A, Oka T, Ferguson K, Sarnak H, Harding C, Kiernan M, Sarnak M, McCallum W. Novel Hemodynamic Markers and Kidney Function in Patients with Acute Decompensated Heart Failure. Kidney360 2025 DOI: 10.34067/kid.0000000703.Peer-Reviewed Original ResearchPulmonary artery pulsatility indexAcute decompensated heart failureAortic pulsatility indexDecompensated heart failureBaseline eGFREGFR slopePulmonary arteryPulsatility indexHeart failureLower pulmonary artery pulsatility indexKidney functionPatients admitted with acute decompensated heart failureMedian follow-up timeMultivariate Cox proportional hazards modelHemodynamic markersArtery pulsatility indexRisk of dialysisFollow-up timeLeft ventricular functionFollow-up periodCox proportional hazards modelsAssociated with higher hazardsProportional hazards modelUnique patient admissionsQuaternary medical center
2024
Peak Tricuspid Regurgitation Jet Velocity and Kidney Outcomes in Patients With Heart Failure With Preserved Ejection Fraction
Oka T, Tighiouart H, McCallum W, Tuttle M, Testani J, Sarnak M. Peak Tricuspid Regurgitation Jet Velocity and Kidney Outcomes in Patients With Heart Failure With Preserved Ejection Fraction. Kidney International Reports 2024, 9: 3035-3044. PMID: 39430198, PMCID: PMC11489825, DOI: 10.1016/j.ekir.2024.07.009.Peer-Reviewed Original ResearchLeft ventricular ejection fractionPulmonary artery pressureCreatinine doublingEGFR declineEjection fractionKidney outcomesHeart failurePeak tricuspid regurgitant jet velocityDoubling of serum creatinineTricuspid regurgitant jet velocityElevated pulmonary artery pressureAssociated with lower eGFRWorsening kidney functionVentricular ejection fractionRegurgitant jet velocityCox proportional hazards modelsProportional hazards modelPost hoc analysisBaseline eGFRSerum creatinineLow eGFRTOPCAT trialFollow-upKidney functionArterial pressure
2013
Influence of Age-Related Versus Non–Age-Related Renal Dysfunction on Survival in Patients With Left Ventricular Dysfunction
Testani JM, Brisco MA, Han G, Laur O, Kula AJ, Cheng SJ, Tang WH, Parikh CR. Influence of Age-Related Versus Non–Age-Related Renal Dysfunction on Survival in Patients With Left Ventricular Dysfunction. The American Journal Of Cardiology 2013, 113: 127-131. PMID: 24216124, PMCID: PMC3915785, DOI: 10.1016/j.amjcard.2013.09.029.Peer-Reviewed Original ResearchConceptsLow glomerular filtration rateGlomerular filtration rateVentricular dysfunctionRenal dysfunctionNormal agingLeft ventricular dysfunctionRisk of deathNormal aging resultsAge-related decreaseInfluence of ageBaseline eGFRMean eGFRLower eGFRWorsened survivalPrognostic importanceFiltration rateSurvival disadvantagePrimary analysisDysfunctionEGFRSignificant riskPatientsUnderlying mechanismRiskMortality