2022
Deep Learning Coronary Artery Calcium Scores from SPECT/CT Attenuation Maps Improve Prediction of Major Adverse Cardiac Events
Miller R, Pieszko K, Shanbhag A, Feher A, Lemley M, Killekar A, Kavanagh PB, Van Kriekinge SD, Liang JX, Huang C, Miller EJ, Bateman T, Berman DS, Dey D, Slomka PJ. Deep Learning Coronary Artery Calcium Scores from SPECT/CT Attenuation Maps Improve Prediction of Major Adverse Cardiac Events. Journal Of Nuclear Medicine 2022, 64: 652-658. PMID: 36207138, PMCID: PMC10071789, DOI: 10.2967/jnumed.122.264423.Peer-Reviewed Original ResearchIntegration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging
Feher A, Pieszko K, Miller R, Lemley M, Shanbhag A, Huang C, Miras L, Liu YH, Sinusas AJ, Miller EJ, Slomka PJ. Integration of coronary artery calcium scoring from CT attenuation scans by machine learning improves prediction of adverse cardiovascular events in patients undergoing SPECT/CT myocardial perfusion imaging. Journal Of Nuclear Cardiology 2022, 30: 590-603. PMID: 36195826, DOI: 10.1007/s12350-022-03099-x.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsMyocardial perfusion imagingAdverse cardiovascular eventsSPECT myocardial perfusion imagingCAC scoringCardiovascular eventsPrediction of MACECoronary artery calcification (CAC) scoringMACE-free survivalClinical risk factorsCoronary artery calciumCT myocardial perfusion imagingReceiver operator characteristic curveSPECT/CT myocardial perfusion imagingSPECT/CTOperator characteristic curveCT myocardial perfusionArtery calciumCAC scoreAnalysis patientsMACE predictionSingle centerHigher event ratesRisk factorsRisk scoreDeep Learning of Coronary Calcium Scores From PET/CT Attenuation Maps Accurately Predicts Adverse Cardiovascular Events
Pieszko K, Shanbhag A, Killekar A, Miller RJH, Lemley M, Otaki Y, Singh A, Kwiecinski J, Gransar H, Van Kriekinge SD, Kavanagh PB, Miller EJ, Bateman T, Liang JX, Berman DS, Dey D, Slomka PJ. Deep Learning of Coronary Calcium Scores From PET/CT Attenuation Maps Accurately Predicts Adverse Cardiovascular Events. JACC Cardiovascular Imaging 2022, 16: 675-687. PMID: 36284402, DOI: 10.1016/j.jcmg.2022.06.006.Peer-Reviewed Original ResearchThe Prognostic Value of CAC Zero Among Individuals Presenting With Chest Pain A Meta-Analysis
Agha AM, Pacor J, Grandhi GR, Mszar R, Khan SU, Parikh R, Agrawal T, Burt J, Blankstein R, Blaha MJ, Shaw LJ, Al-Mallah MH, Brackett A, Cainzos-Achirica M, Miller EJ, Nasir K. The Prognostic Value of CAC Zero Among Individuals Presenting With Chest Pain A Meta-Analysis. JACC Cardiovascular Imaging 2022, 15: 1745-1757. PMID: 36202453, DOI: 10.1016/j.jcmg.2022.03.031.Peer-Reviewed Original ResearchConceptsObstructive coronary artery diseaseAcute chest painCoronary artery calciumCoronary artery diseaseStable chest painNonobstructive coronary artery diseaseMajor adverse cardiac eventsAdverse cardiac eventsChest painCardiac eventsLow prevalenceAbsence of CACHealth care delivery modelsCare delivery modelsA Meta-AnalysisNegative predictive valueCAC assessmentArtery calciumCAC scoreIntermediate riskArtery diseaseCoronary CTACTA assessmentPrognostic valueTomography angiography
2017
Up-regulation of Intracellular Calcium Handling Underlies the Recovery of Endotoxemic Cardiomyopathy in Mice
Morse JC, Huang J, Khona N, Miller EJ, Siwik DA, Colucci WS, Hobai IA. Up-regulation of Intracellular Calcium Handling Underlies the Recovery of Endotoxemic Cardiomyopathy in Mice. Anesthesiology 2017, 126: 1125-1138. PMID: 28410273, DOI: 10.1097/aln.0000000000001627.Peer-Reviewed Original ResearchConceptsCalcium transientsCardiac recoveryLipopolysaccharide challengeCalcium handlingDay 3Sarcomere shorteningCardiomyocyte calcium handlingSepsis-induced cardiomyopathyVentricular ejection fractionIntracellular calcium handlingSarcoplasmic reticulum calcium loadMale C57BL/6 miceSodium/calcium exchangeMyocardial protein expressionSarcoplasmic reticulum calcium pumpSystemic inflammationEjection fractionEndotoxemic miceC57BL/6 miceMyocardial mechanismsCardiac functionCalcium loadCardiac contractilityBaseline levelsDay 6