2023
Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases
Chan N, Einstein A, Griffin J, Rosenblum H, Teruya S, Cuomo M, De Los Santos J, DeLuca A, Johnson L, Kinkhabwala M, Leb J, Mintz A, Fine D, Helmke S, Muralidhar V, Pandey S, Sabogal N, Saith S, Winburn M, Smiley D, Miller E, Ruberg F, Maurer M. Prevalence and significance of extracardiac uptake on pyrophosphate imaging in the SCAN-MP study: the first 379 cases. Journal Of Nuclear Cardiology 2023, 30: 2531-2539. PMID: 37311914, DOI: 10.1007/s12350-023-03310-7.Peer-Reviewed Original ResearchConceptsExtracardiac uptakePYP uptakeCardiac amyloidosisBone uptakeActionable findingsTiming of scansTransthyretin cardiac amyloidosisHeart failureBreast uptakeMean ageBlack raceRenal uptakeHispanic ethnicityThyroid uptakeATTR-CANuclear scintigraphyHispanic participantsTechnetium pyrophosphateNuclear imagingPYP scanPopulation studiesSelf-identified BlackAdditional testingAmyloidosisSubjectsDiagnostic performance characteristics of planar quantitative and semi-quantitative parameters of Tc99m pyrophosphate (PYP) imaging for diagnosis of transthyretin (ATTR) cardiac amyloidosis: the SCAN-MP study
Pandey S, Teruya S, Rodriguez C, Deluca A, Kinkhabwala M, Johnson L, Fine D, Sabogal N, Winburn M, Castillo M, Bhatia K, Malkovskaya R, Raiszadeh F, Kurian D, Miller E, Einstein A, Maurer M, Ruberg F. Diagnostic performance characteristics of planar quantitative and semi-quantitative parameters of Tc99m pyrophosphate (PYP) imaging for diagnosis of transthyretin (ATTR) cardiac amyloidosis: the SCAN-MP study. Journal Of Nuclear Cardiology 2023, 30: 1414-1419. PMID: 36823486, PMCID: PMC11268194, DOI: 10.1007/s12350-023-03203-9.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmyloidosisCardiomyopathiesDiphosphatesHumansPrealbuminRadiopharmaceuticalsTechnetiumTechnetium Tc 99m PyrophosphateConceptsTransthyretin cardiac amyloidosisATTR-CACardiac amyloidosisLow pretest probabilityLow pretest likelihoodLV wall thicknessDiagnostic performance characteristicsPositive predictive valueNon-invasive diagnosisConclusionAmong patientsMinority older adultsHeart failurePretest likelihoodPretest probabilitySemi-quantitative parametersPYP uptakeImportant misclassificationPredictive valueImaging thresholdsOptimal heartOlder adultsDiagnostic performancePatientsReference standardScans
2022
Radiopharmaceutical supply disruptions and the use of 99mTc-hydroxymethylene diphosphonate as an alternative to 99mTc-pyrophosphate for the diagnosis of transthyretin cardiac amyloidosis: An ASNC Information Statement
Miller EJ, Campisi R, Shah NR, McMahon S, Cuddy S, Gallegos-Kattan C, Maurer MS, Damy T, Slart RHJA, Bhatia K, Einstein AJ. Radiopharmaceutical supply disruptions and the use of 99mTc-hydroxymethylene diphosphonate as an alternative to 99mTc-pyrophosphate for the diagnosis of transthyretin cardiac amyloidosis: An ASNC Information Statement. Journal Of Nuclear Cardiology 2022, 29: 2748-2760. PMID: 35838892, PMCID: PMC9285188, DOI: 10.1007/s12350-022-03059-5.Peer-Reviewed Original Research
2021
Potential novel imaging targets of inflammation in cardiac sarcoidosis
Park J, Young BD, Miller EJ. Potential novel imaging targets of inflammation in cardiac sarcoidosis. Journal Of Nuclear Cardiology 2021, 29: 2171-2187. PMID: 34734365, DOI: 10.1007/s12350-021-02838-w.Peer-Reviewed Original ResearchMeSH KeywordsCardiomyopathiesFluorodeoxyglucose F18HumansInflammationMyocarditisPositron-Emission TomographyRadiopharmaceuticalsReproducibility of ResultsSarcoidosisConceptsCardiac sarcoidosisFDG-PET imagingPositron emission tomographyF-fluorodeoxyglucose positron emission tomographyNon-caseating granulomatous inflammationGranulomatous inflammationHigh morbiditySarcoid granulomasInflammatory diseasesPathognomonic featuresInflammationEmission tomographySarcoidosisMolecular targetsImaging targetsImagingMorbidityGranulomasMortalityDiseaseCytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging
Young BD, Moreland H, Oatmen KE, Freeburg LA, Shahab Z, Herzog E, Miller EJ, Spinale FG. Cytokine Signaling and Matrix Remodeling Pathways Associated with Cardiac Sarcoidosis Disease Activity Defined Using FDG PET Imaging. International Heart Journal 2021, 62: 21-164. PMID: 34544982, DOI: 10.1536/ihj.21-164.Peer-Reviewed Original ResearchMeSH KeywordsAgedBiomarkersCase-Control StudiesCytokinesEvaluation Studies as TopicFemaleFluorodeoxyglucose F18Heart DiseasesHumansImmunosuppressive AgentsInflammationMaleMatrix Metalloproteinase InhibitorsMatrix MetalloproteinasesMiddle AgedPositron-Emission TomographyProspective StudiesRadiopharmaceuticalsReceptors, Interleukin-2Receptors, Tumor Necrosis FactorRisk AssessmentSarcoidosisSeverity of Illness IndexTumor Necrosis Factor-alphaVascular Endothelial Growth Factor AConceptsTumor necrosis factorSoluble cytokine receptorsCardiac sarcoidosisCS patientsMatrix metalloproteinasePlasma MMP-9 levelsFluorodeoxyglucose positron emission tomographyPlasma tumor necrosis factorAnti-inflammatory regimensBiopsy-confirmed sarcoidosisReferent control valuesSarcoidosis disease activityVascular endothelial growth factor receptorHeart failure therapySoluble TNF receptorsEndothelial growth factor receptorMMP-9 levelsSpecific inflammatory pathwaysFDG-PET imagingEndogenous MMP inhibitorsCytokine receptorsPositron emission tomographyCytokine receptor profilesGrowth factor receptorSIL-2ROptimal interpretation of Tc99m PYP in 2020: Avoiding the million-dollar mistake
Gerber J, Miller EJ. Optimal interpretation of Tc99m PYP in 2020: Avoiding the million-dollar mistake. Journal Of Nuclear Cardiology 2021, 28: 503-506. PMID: 33442822, DOI: 10.1007/s12350-020-02503-8.Peer-Reviewed Original Research
2020
Complex cellular physiology underlies the use of FDG-PET imaging in investigating post-infarction remodeling
Miller EJ. Complex cellular physiology underlies the use of FDG-PET imaging in investigating post-infarction remodeling. Journal Of Nuclear Cardiology 2020, 27: 532-533. PMID: 31907858, DOI: 10.1007/s12350-019-02008-z.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsFluorodeoxyglucose F18InflammationMyocardial InfarctionPositron-Emission TomographyRadiopharmaceuticalsSwine
2019
New approach for quantification of left ventricular function from low-dose gated bloodpool SPECT: Validation and comparison with conventional methods in patients
Liu YH, Fazzone-Chettiar R, Sandoval V, Tsatkin V, Miller EJ, Sinusas AJ. New approach for quantification of left ventricular function from low-dose gated bloodpool SPECT: Validation and comparison with conventional methods in patients. Journal Of Nuclear Cardiology 2019, 28: 939-950. PMID: 31338796, DOI: 10.1007/s12350-019-01823-8.Peer-Reviewed Original ResearchConceptsLV functionEquilibrium radionuclide angiocardiographyInter-observer reproducibilityRed blood cellsVentricular functionLeft ventricular functionExcellent inter-observer reproducibilityHigh-dose injectionLow-dose injectionsUnderwent standardRadionuclide angiocardiographyRadioactive doseShort-axis slicesRegional functionBlood cellsRadiation exposureGold standardImaging modalitiesAxis slicesPatientsDedicated cardiac SPECT cameraDoseSPECTInjectionDifferent quantification methodsRepeatability and Optimization of FDG Positron Emission Tomography for Evaluation of Cardiac Sarcoidosis
Alvi RM, Young BD, Shahab Z, Pan H, Winkler J, Herzog E, Miller EJ. Repeatability and Optimization of FDG Positron Emission Tomography for Evaluation of Cardiac Sarcoidosis. JACC Cardiovascular Imaging 2019, 12: 1284-1287. PMID: 30846271, DOI: 10.1016/j.jcmg.2019.01.011.Peer-Reviewed Original ResearchUsing FDG-PET to guide targeted cardiac magnetic resonance imaging in patients with suspected cardiac sarcoidosis
Sharp MB, Soufer A, Abdelmessih M, Rosenfeld LE, Baldassarre LA, Miller EJ. Using FDG-PET to guide targeted cardiac magnetic resonance imaging in patients with suspected cardiac sarcoidosis. Journal Of Nuclear Cardiology 2019, 27: 688-690. PMID: 30737635, DOI: 10.1007/s12350-019-01640-z.Peer-Reviewed Original ResearchPET-Based Imaging of Ischemic Heart Disease
Chen K, Miller EJ, Sadeghi MM. PET-Based Imaging of Ischemic Heart Disease. PET Clinics 2019, 14: 211-221. PMID: 30826019, PMCID: PMC6426655, DOI: 10.1016/j.cpet.2018.12.003.Peer-Reviewed Original ResearchMeSH KeywordsComputed Tomography AngiographyCoronary Artery DiseaseCoronary CirculationCost-Benefit AnalysisFractional Flow Reserve, MyocardialHumansMultimodal ImagingMyocardial IschemiaMyocardial Perfusion ImagingPositron-Emission TomographyPrognosisRadiopharmaceuticalsSensitivity and SpecificityTomography, Emission-Computed, Single-PhotonConceptsIschemic heart diseaseHeart diseaseCoronary artery diseaseCardiac nuclear imagingCoronary flow reserveAtherosclerotic plaque vulnerabilityMyocardial blood flowCT myocardial perfusionArtery diseaseIschemic cardiomyopathyMicrovascular diseaseVascular calcificationFlow reserveVascular remodelingMyocardial viabilityPlaque vulnerabilityBlood flowMyocardial perfusionMolecular imaging toolDiseaseNuclear imagingImaging toolPETImagingPrognosis
2018
Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients
Feher A, Srivastava A, Quail MA, Boutagy NE, Khanna P, Wilson L, Miller EJ, Liu YH, Lee F, Sinusas AJ. Serial Assessment of Coronary Flow Reserve by Rubidium-82 Positron Emission Tomography Predicts Mortality in Heart Transplant Recipients. JACC Cardiovascular Imaging 2018, 13: 109-120. PMID: 30343093, PMCID: PMC6461525, DOI: 10.1016/j.jcmg.2018.08.025.Peer-Reviewed Original ResearchMeSH KeywordsAgedCoronary Artery DiseaseFemaleFractional Flow Reserve, MyocardialHeart TransplantationHumansMaleMiddle AgedMyocardial Perfusion ImagingPositron-Emission TomographyPredictive Value of TestsProspective StudiesRadiopharmaceuticalsReproducibility of ResultsRubidium RadioisotopesTime FactorsTreatment OutcomeConceptsPositron emission tomographyLong-term prognostic valueSerial assessmentPET-2Pet-1Cause mortalityHT patientsPrognostic valueHigh CFRLow CFRRb positron-emission tomographyEmission tomographyRb-82 positron emission tomographyRubidium-82 positron emission tomographyPET imagingHeart transplantation patientsHistory of HTCardiac allograft vasculopathyHeart transplant recipientsLong-term mortalitySingle-center studyMultivariate Cox regressionCoronary flow reserveAllograft vasculopathyHT recipientsDeep Learning for Prediction of Obstructive Disease From Fast Myocardial Perfusion SPECT A Multicenter Study
Betancur J, Commandeur F, Motlagh M, Sharir T, Einstein AJ, Bokhari S, Fish MB, Ruddy TD, Kaufmann P, Sinusas AJ, Miller EJ, Bateman TM, Dorbala S, Di Carli M, Germano G, Otaki Y, Tamarappoo BK, Dey D, Berman DS, Slomka PJ. Deep Learning for Prediction of Obstructive Disease From Fast Myocardial Perfusion SPECT A Multicenter Study. JACC Cardiovascular Imaging 2018, 11: 1654-1663. PMID: 29550305, PMCID: PMC6135711, DOI: 10.1016/j.jcmg.2018.01.020.Peer-Reviewed Original ResearchMeSH KeywordsAgedAged, 80 and overCoronary CirculationCoronary StenosisDeep LearningFemaleHumansImage Interpretation, Computer-AssistedMaleMiddle AgedMyocardial Perfusion ImagingOrganophosphorus CompoundsOrganotechnetium CompoundsPredictive Value of TestsRadiopharmaceuticalsRegistriesTechnetium Tc 99m SestamibiTomography, Emission-Computed, Single-PhotonConceptsTotal perfusion deficitMyocardial perfusion imagingCoronary artery diseaseObstructive diseaseArtery diseaseVessel coronary artery diseaseTomography myocardial perfusion imagingTetrofosmin myocardial perfusion imagingLarge multicenter populationStress total perfusion deficitReceiver-operating characteristic curveInvasive coronary angiographyLeft ventricular myocardiumSingle photon emissionMyocardial perfusion SPECTMonths of MPIMulticenter populationObstructive stenosisCoronary angiographyMulticenter studyCoronary arteryPerfusion deficitsNormal limitsVessel sensitivityCurrent clinical methods
2017
Diagnosis of extensive myocardial infiltration by diffuse large B-cell lymphoma using 18F-fluorodeoxyglucose positron emission tomography (18-FDG PET)
Higgins AY, Taylor EP, Baldassarre LA, Miller EJ, Rosenfeld LE. Diagnosis of extensive myocardial infiltration by diffuse large B-cell lymphoma using 18F-fluorodeoxyglucose positron emission tomography (18-FDG PET). Journal Of Nuclear Cardiology 2017, 25: 1869-1871. PMID: 29116563, DOI: 10.1007/s12350-017-1099-1.Peer-Reviewed Case Reports and Technical NotesJoint SNMMI–ASNC expert consensus document on the role of 18F-FDG PET/CT in cardiac sarcoid detection and therapy monitoring
Chareonthaitawee P, Beanlands RS, Chen W, Dorbala S, Miller EJ, Murthy VL, Birnie DH, Chen ES, Cooper LT, Tung RH, White ES, Borges-Neto S, Di Carli MF, Gropler RJ, Ruddy TD, Schindler TH, Blankstein R. Joint SNMMI–ASNC expert consensus document on the role of 18F-FDG PET/CT in cardiac sarcoid detection and therapy monitoring. Journal Of Nuclear Cardiology 2017, 24: 1741-1758. PMID: 28770463, DOI: 10.1007/s12350-017-0978-9.Peer-Reviewed Original Research
2016
Multicenter Study of Planar Technetium 99m Pyrophosphate Cardiac Imaging: Predicting Survival for Patients With ATTR Cardiac Amyloidosis
Castano A, Haq M, Narotsky DL, Goldsmith J, Weinberg RL, Morgenstern R, Pozniakoff T, Ruberg FL, Miller EJ, Berk JL, Dispenzieri A, Grogan M, Johnson G, Bokhari S, Maurer MS. Multicenter Study of Planar Technetium 99m Pyrophosphate Cardiac Imaging: Predicting Survival for Patients With ATTR Cardiac Amyloidosis. JAMA Cardiology 2016, 1: 880-889. PMID: 27557400, DOI: 10.1001/jamacardio.2016.2839.Peer-Reviewed Original ResearchMeSH KeywordsAgedAmyloidosisCardiomyopathiesDiphosphatesFemaleHeartHumansMaleRadionuclide ImagingRadiopharmaceuticalsRetrospective StudiesTechnetiumConceptsATTR cardiac amyloidosisCardiac amyloidosisMulticenter studyWorse survivalEjection fractionHeart failureCardiac imagingMultivariable Cox proportional hazards regression analysisCox proportional hazards regression analysisProportional hazards regression analysisRetrospective cohort studyHigh clinical suspicionSingle-center studyHazards regression analysisKaplan-Meier analysisAL cardiac amyloidosisDifferentiation of patientsTransthyretin cardiac amyloidosisDates of analysisSemiquantitative visual scoreContralateral chestPlanar technetiumClinical suspicionCohort studyPrognostic importanceCan 99mTc-Pyrophosphate Aid in Early Detection of Cardiac Involvement in Asymptomatic Variant TTR Amyloidosis?
Haq M, Pawar S, Berk JL, Miller EJ, Ruberg FL. Can 99mTc-Pyrophosphate Aid in Early Detection of Cardiac Involvement in Asymptomatic Variant TTR Amyloidosis? JACC Cardiovascular Imaging 2016, 10: 713-714. PMID: 27568122, PMCID: PMC5318295, DOI: 10.1016/j.jcmg.2016.06.003.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overAmyloid Neuropathies, FamilialAsymptomatic DiseasesCardiomyopathiesDisease ProgressionEarly DiagnosisFemaleGenetic Predisposition to DiseaseHeart FailureHumansMaleMiddle AgedMutationPhenotypePrealbuminPredictive Value of TestsRadionuclide ImagingRadiopharmaceuticalsTechnetium Tc 99m PyrophosphateThe response of FDG uptake to immunosuppressive treatment on FDG PET/CT imaging for cardiac sarcoidosis
Ahmadian A, Pawar S, Govender P, Berman J, Ruberg FL, Miller EJ. The response of FDG uptake to immunosuppressive treatment on FDG PET/CT imaging for cardiac sarcoidosis. Journal Of Nuclear Cardiology 2016, 24: 413-424. PMID: 27457527, DOI: 10.1007/s12350-016-0490-7.Peer-Reviewed Original ResearchConceptsFDG PET/CTPET/CTFDG uptakeCardiac sarcoidosisFDG PET/CT studiesPET/CT studiesImmunosuppressive treatmentCardiac inflammationPartial responseComplete resolutionImproved outcomesSUV thresholdImmunosuppressionFDG responseCT studiesPatientsCTSarcoidosisFurther studiesQuantitative changesUptakeResponseInflammationSUVmaxCMVNational patterns in imaging utilization for diagnosis of cardiac amyloidosis: A focus on Tc99m-pyrophosphate scintigraphy
Harb SC, Haq M, Flood K, Guerrieri A, Passerell W, Jaber WA, Miller EJ. National patterns in imaging utilization for diagnosis of cardiac amyloidosis: A focus on Tc99m-pyrophosphate scintigraphy. Journal Of Nuclear Cardiology 2016, 24: 1094-1097. PMID: 27016106, DOI: 10.1007/s12350-016-0478-3.Peer-Reviewed Original ResearchConceptsCardiac amyloidosisCA diagnosisContralateral lung ratioTransthyretin cardiac amyloidosisLung ratioDiagnostic modalitiesMost centersTest utilizationWeb-based surveyScintigraphyMultiple centersDiagnosisQuantification of uptakeLow penetranceNational surveyAmyloidosisNational patternsCardiologistsDose
2015
Quantifying FDG uptake to diagnose cardiac device infections: When and how should we do it?
Blankstein R, Miller EJ. Quantifying FDG uptake to diagnose cardiac device infections: When and how should we do it? Journal Of Nuclear Cardiology 2015, 23: 1467-1469. PMID: 26494648, DOI: 10.1007/s12350-015-0293-2.Peer-Reviewed Original Research