2025
Contemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation.
Park D, McLean B, Akman Z, Li D, Babapour G, Nanna M. Contemporary Use and Clinical Significance of Initial Triple Versus Double Therapy After Percutaneous Coronary Intervention for Myocardial Infarction in Patients With Atrial Fibrillation. Journal Of The American Heart Association 2025, 14: e038589. PMID: 40401606, DOI: 10.1161/jaha.124.038589.Peer-Reviewed Original ResearchMeSH KeywordsAgedAnticoagulantsAspirinAtrial FibrillationClinical RelevanceDrug Therapy, CombinationDual Anti-Platelet TherapyFemaleHemorrhageHospital MortalityHumansMaleMiddle AgedMyocardial InfarctionPercutaneous Coronary InterventionPlatelet Aggregation InhibitorsRetrospective StudiesTime FactorsTreatment OutcomeConceptsPercutaneous coronary interventionST-segment elevation myocardial infarctionDouble therapyTriple therapyClinical adverse eventsIn-hospital mortalityAtrial fibrillationPost-PCIMyocardial infarctionIntracranial hemorrhageAdverse eventsCourse of triple therapyCoronary interventionStent thrombosisInverse probability of treatment weightingProbability of treatment weightingHigh-risk subgroupsMultivariate logistic regressionAssociated with higher oddsRandomized trial evidenceNo significant differenceVizient Clinical DatabaseClinical significancePrescribing patternsCompare outcomesSex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention
Gomez J, Park D, Eder M, An S, Lowenstern A, Kelsey M, Rymer J, Douglas P, Nanna M. Sex differences in in-hospital outcomes and readmission rates after percutaneous coronary intervention. Baylor University Medical Center Proceedings 2025, 38: 159-169. PMID: 39990004, PMCID: PMC11845020, DOI: 10.1080/08998280.2025.2452113.Peer-Reviewed Original ResearchIn-hospital outcomesIn-hospital mortalitySecondary outcomesReadmission ratesOdds of in-hospital mortalityPercutaneous coronary interventionCalculate odds ratiosInpatient percutaneous coronary interventionHazard of readmissionUnited States National Readmission DatabaseIn-hospital adverse outcomesPropensity score matchingHealth systemHospital characteristicsOdds of cardiac arrestSocioeconomic statusReimbursement implicationsSex differencesYears of ageOdds ratioReadmission riskCox proportional-hazardsLogistic regressionIn-hospital complicationsScore matchingSex Differences in the Safety and Efficacy of Different Durations of DAPT After PCI
Park D, Mahajan S, Fishman E, Ambrosini A, Acero L, Hu J, Campbell G, Babapour G, Kelsey M, Douglas P, Gupta A, Frampton J, Nanna M. Sex Differences in the Safety and Efficacy of Different Durations of DAPT After PCI. JACC Advances 2025, 4: 101543. PMID: 39886301, PMCID: PMC11780104, DOI: 10.1016/j.jacadv.2024.101543.Peer-Reviewed Original ResearchMonths of DAPTDuration of dual antiplatelet therapyNet adverse clinical eventsDuration of DAPTRandomized controlled trialsPercutaneous coronary interventionShorter duration of dual antiplatelet therapyRisk of bleedingBleeding riskLow risk of bleedingSex-based differencesAssociated with lower riskAdverse clinical eventsDual antiplatelet therapyAdverse cardiovascular eventsNetwork meta-analysisWeb of Science databasesAntiplatelet therapyClinical impactCardiovascular eventsClinical eventsSystematic reviewSignificant sex-based differencesControlled trialsCoronary intervention
2024
Complete revascularization versus culprit‐only revascularization in older adults with ST‐elevation myocardial infarction: Systematic review and meta‐analysis of randomized controlled trials
Park D, Hu J, Frampton J, Rymer J, Al Damluji A, Nanna M. Complete revascularization versus culprit‐only revascularization in older adults with ST‐elevation myocardial infarction: Systematic review and meta‐analysis of randomized controlled trials. Journal Of The American Geriatrics Society 2024, 73: 874-880. PMID: 39639558, PMCID: PMC11908960, DOI: 10.1111/jgs.19295.Peer-Reviewed Original ResearchContrast-associated acute kidney injuryST-elevation myocardial infarctionCulprit-only revascularizationRandomized controlled trialsComplete revascularizationHazard of MACEMeta-analysisOlder adultsHazard ratioClass III to class IMeta-analysis of randomized controlled trialsAssociated with reduced MACEMyocardial infarctionControlled trialsAcute kidney injuryRandomized controlled trials of CRAdverse cardiovascular eventsBenefits of CRComplexity of lesionsRandom-effects modelBleeding riskKidney injuryMeta-analysis to dateCardiovascular eventsSubgroup analysisTrend of Controlled Low-Density Lipoprotein Cholesterol in Older Adults With a History of Myocardial Infarction or Stroke
Park D, Jamil Y, Frampton J, Al Damluji A, Nanna M. Trend of Controlled Low-Density Lipoprotein Cholesterol in Older Adults With a History of Myocardial Infarction or Stroke. JACC Advances 2024, 3: 101091. PMID: 39099776, PMCID: PMC11294686, DOI: 10.1016/j.jacadv.2024.101091.Peer-Reviewed Original ResearchRepresentation of Older Adults in the ACC/AHA/SCAI Guideline for Coronary Artery Revascularization
Jamil Y, Sibindi C, Park D, Frampton J, Damluji A, Nanna M. Representation of Older Adults in the ACC/AHA/SCAI Guideline for Coronary Artery Revascularization. JAMA Network Open 2024, 7: e2421547. PMID: 38995647, PMCID: PMC11245718, DOI: 10.1001/jamanetworkopen.2024.21547.Peer-Reviewed Original ResearchQuality of Life in Older Adults With Stable Ischemic Heart Disease and Diabetes Mellitus: A Post Hoc Analysis of the BARI 2D Trial
Park D, Jamil Y, Moumneh M, Batchelor B W, Nanna M, Damluji A. Quality of Life in Older Adults With Stable Ischemic Heart Disease and Diabetes Mellitus: A Post Hoc Analysis of the BARI 2D Trial. The American Journal Of Cardiology 2024, 223: 58-69. PMID: 38797195, PMCID: PMC11214881, DOI: 10.1016/j.amjcard.2024.05.016.Peer-Reviewed Original ResearchDuke Activity Status IndexOlder adultsYears of follow-upStable ischemic heart diseaseIntensive medical therapyQoL measuresStatus indexIschemic heart diseaseDistress ratingsOlder adult populationOlder adult patientsBARI 2D trialDiabetes mellitusQuality of lifeQuality-of-lifeHeart diseaseMultivariate linear regressionFollow-upMedical therapyAdult populationQoLCognitive impairmentOlder patientsPost hoc analysisChronic total occlusionAssociation Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock
Jamil Y, Park D, Rao S, Ahmad Y, Sikand N, Bosworth H, Coles T, Damluji A, Nanna M, Samsky M. Association Between Frailty and Management and Outcomes of Acute Myocardial Infarction Complicated by Cardiogenic Shock. JACC Advances 2024, 3: 100949. PMID: 38938859, PMCID: PMC11198471, DOI: 10.1016/j.jacadv.2024.100949.Peer-Reviewed Original ResearchAcute myocardial infarctionAMI-CSIn-hospital outcomesDo-not-resuscitate statusPatients admitted with acute myocardial infarctionOdds of in-hospital mortalitySkilled nursing facilityPrevalence of frailtyProportion of hospitalsAssociated with in-hospital outcomesIn-hospital adverse eventsCompare in-hospital outcomesRisk score cut-offNational Inpatient SampleNursing facilitiesIn-hospital mortalityScore cut-offAssociated with adverse outcomesInpatient SampleFrailtyCardiogenic shockIn-hospital morbidityMyocardial infarction complicationsNonfrail groupOddsSeasonal variations in admissions for atrial fibrillation or atrial flutter in the Northeast and the Midwest regions of the United States
Park D, Bittar-Carlini G, Kumar M, Jamil Y, Nanna M. Seasonal variations in admissions for atrial fibrillation or atrial flutter in the Northeast and the Midwest regions of the United States. Baylor University Medical Center Proceedings 2024, 37: 560-568. PMID: 38910792, PMCID: PMC11188794, DOI: 10.1080/08998280.2024.2346050.Peer-Reviewed Original ResearchFrailty and In-Hospital Outcomes for Management of Cardiogenic Shock without Acute Myocardial Infarction
Park D, Jamil Y, Ahmad Y, Coles T, Bosworth H, Sikand N, Davila C, Babapour G, Damluji A, Rao S, Nanna M, Samsky M. Frailty and In-Hospital Outcomes for Management of Cardiogenic Shock without Acute Myocardial Infarction. Journal Of Clinical Medicine 2024, 13: 2078. PMID: 38610842, PMCID: PMC11012362, DOI: 10.3390/jcm13072078.Peer-Reviewed Original ResearchDo-not-resuscitate statusOdds of in-hospital mortalitySkilled nursing facilityIn-hospital adverse eventsRelationship of frailtyCompare in-hospital outcomesNon-frail groupRisk score cut-offNational Inpatient SampleAssociated with increased rates of morbidityNursing facilitiesMyocardial infarctionAssociated with increased ratesFrail adultsIn-hospital mortalityIn-hospital outcomesAcute myocardial infarctionFrail groupScore cut-offFrailtyInpatient SampleCardiogenic shockRisk factorsCardiovascular diseaseHospitalAssociation of cardiovascular diseases with cognitive performance in older adults
Park D, Jamil Y, Babapour G, Kim J, Campbell G, Akman Z, Kochar A, Sen S, Samsky M, Sikand N, Frampton J, Damluji A, Nanna M. Association of cardiovascular diseases with cognitive performance in older adults. American Heart Journal 2024, 273: 10-20. PMID: 38575050, PMCID: PMC11162917, DOI: 10.1016/j.ahj.2024.03.016.Peer-Reviewed Original ResearchAnimal Fluency TestOlder adultsCERAD-DRDSST scoresCardiovascular diseaseNational Health and Nutrition Examination SurveyHealth and Nutrition Examination SurveyCongestive heart failureFree of cardiovascular diseaseFluency testCardiovascular disease subtypesNutrition Examination SurveyAssociation of cardiovascular diseaseAnimal Fluency test scoreCognitive performanceLower cognitive performanceCoronary heart diseaseHeart failureCVD subtypesExamination SurveyAssess cognitive performanceAdultsCognitive functionHeart diseaseScoresREPRESENTATION OF OLDER ADULTS IN THE CURRENT ACC/AHA/SCAI GUIDELINE FOR CORONARY ARTERY REVASCULARIZATION
Jamil Y, Sibindi C, Park D, Frampton J, Damluji A, Nanna M. REPRESENTATION OF OLDER ADULTS IN THE CURRENT ACC/AHA/SCAI GUIDELINE FOR CORONARY ARTERY REVASCULARIZATION. Journal Of The American College Of Cardiology 2024, 83: 852. DOI: 10.1016/s0735-1097(24)02842-0.Peer-Reviewed Original ResearchDuration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Network Meta-analysis
Park D, Hu J, Campbell G, Goldwag K, Kelsey M, Altin S, Gallegos-Kattán C, Nanna M. Duration of Dual Antiplatelet Therapy After Percutaneous Coronary Intervention in Patients With Type 2 Diabetes Mellitus: A Systematic Review and Network Meta-analysis. Journal Of The Society For Cardiovascular Angiography & Interventions 2024, 3: 101859. PMID: 39131993, PMCID: PMC11307649, DOI: 10.1016/j.jscai.2024.101859.Peer-Reviewed Original ResearchMonths of DAPTDuration of dual antiplatelet therapyNet adverse clinical eventsType 2 diabetes mellitusDual antiplatelet therapyAcute coronary syndromeRandomized controlled trialsSensitivity analysis of trialsPercutaneous coronary interventionCoronary interventionNo significant differenceAntiplatelet therapyAnalysis of trialsCoronary syndromeControlled trialsMeta-analysis of patientsStent thrombosisMeta-analysisDAPT durationClinicians greater flexibilityStudy-level meta-analysisOptimal duration of dual antiplatelet therapyHigher risk of adverse eventsPostpercutaneous coronary interventionRisk of adverse eventsShorter Dual Antiplatelet Therapy for Older Adults After Percutaneous Coronary Intervention
Park D, Hu J, Jamil Y, Kelsey M, Jones W, Frampton J, Kochar A, Aronow W, Damluji A, Nanna M. Shorter Dual Antiplatelet Therapy for Older Adults After Percutaneous Coronary Intervention. JAMA Network Open 2024, 7: e244000. PMID: 38546647, PMCID: PMC10979312, DOI: 10.1001/jamanetworkopen.2024.4000.Peer-Reviewed Original ResearchConceptsOlder adultsMonths of DAPTDuration of dual antiplatelet therapySystematic reviewRandomized clinical trialsPercutaneous coronary interventionMeta-analysisPreferred Reporting ItemsAssess data qualityRisk of bleedingDuration of DAPTDual antiplatelet therapyWeb of ScienceMain OutcomesReporting ItemsData extractionAbstracted dataSecondary outcomesRisk ratioAntiplatelet therapyPrimary outcomeCochrane LibraryCoronary interventionReference groupNetwork meta-analysis
2023
Do Clinical Outcomes and Quality of Life Differ by the Number of Antianginals for Stable Ischemic Heart Disease? Insights from the BARI 2D Trial
Jamil Y, Park D, Verde L, Sherwood M, Tehrani B, Batchelor W, Frampton J, Damluji A, Nanna M. Do Clinical Outcomes and Quality of Life Differ by the Number of Antianginals for Stable Ischemic Heart Disease? Insights from the BARI 2D Trial. The American Journal Of Cardiology 2023, 214: 66-76. PMID: 38160927, PMCID: PMC10923116, DOI: 10.1016/j.amjcard.2023.12.045.Peer-Reviewed Original ResearchStable ischemic heart diseaseAnti-anginal agentIntensive medical therapyIschemic heart diseaseMedical therapyQOL metricsHeart diseaseFindings merit further researchMajor adverse cardiovascular eventsAnti-anginal treatmentBARI 2D trialGreater QoL improvementAdverse cardiovascular eventsMyocardial jeopardy indexCardiovascular eventsCause mortalityCardiovascular endpointsClinical confoundersPatient characteristicsDiabetes mellitusHeart failureTherapy intensityClinical outcomesQOL improvementMyocardial infarctionThe association of timing of coronary artery bypass grafting for non-ST-elevation myocardial infarction and clinical outcomes in the contemporary United States
Park D, Singireddy S, Mangalesh S, Fishman E, Ambrosini A, Jamil Y, Vij A, Sikand N, Ahmad Y, Frampton J, Nanna M. The association of timing of coronary artery bypass grafting for non-ST-elevation myocardial infarction and clinical outcomes in the contemporary United States. Coronary Artery Disease 2023, 35: 261-269. PMID: 38164979, PMCID: PMC11042982, DOI: 10.1097/mca.0000000000001314.Peer-Reviewed Original ResearchLength of stayCoronary artery bypassElevation myocardial infarctionNSTEMI hospitalizationsHospital mortalityArtery bypassCABG surgeryMyocardial infarctionHigher oddsLonger LOSBurden of complicationsHospital-associated costsNon-home dischargeAcute kidney injuryHigh-risk featuresPercutaneous coronary interventionAssociation of timingOutcomes of interestNSTEMI populationGastrointestinal hemorrhageHospital outcomesKidney injuryPerioperative complicationsCoronary interventionBlood transfusionComplex Percutaneous Coronary Intervention Outcomes in Older Adults
Hanna J, Wang S, Kochar A, Park D, Damluji A, Henry G, Ahmad Y, Curtis J, Nanna M. Complex Percutaneous Coronary Intervention Outcomes in Older Adults. Journal Of The American Heart Association 2023, 12: e029057. PMID: 37776222, PMCID: PMC10727245, DOI: 10.1161/jaha.122.029057.Peer-Reviewed Original ResearchConceptsNoncomplex percutaneous coronary interventionsComplex percutaneous coronary interventionStable ischemic heart diseasePercutaneous coronary interventionIschemic heart diseaseTarget lesion revascularizationEvent-free survivalHeart diseaseOlder adultsCause deathLesion revascularizationClinical characteristicsElective percutaneous coronary interventionPercutaneous coronary intervention outcomesWorse event-free survivalMedical therapy useCox regression modelLarge health systemNoncardiac comorbiditiesRevascularization riskCoronary interventionTherapy useClinical outcomesDisease featuresLower riskTrends and Inhospital Outcomes of Intravascular Imaging on Single-Vessel Coronary Chronic Total Occlusion Treated With Percutaneous Coronary Intervention
Park D, Hu J, Kanitsoraphan C, Al-Ogaili A, Murthi M, Vardar U, Ahmad Y, Nanna M, Vij A. Trends and Inhospital Outcomes of Intravascular Imaging on Single-Vessel Coronary Chronic Total Occlusion Treated With Percutaneous Coronary Intervention. The American Journal Of Cardiology 2023, 206: 79-85. PMID: 37683583, PMCID: PMC10901566, DOI: 10.1016/j.amjcard.2023.08.051.Peer-Reviewed Original ResearchPercutaneous coronary interventionChronic total occlusionInhospital mortalityIntravascular ultrasoundOptical coherence tomographyInhospital outcomesIntravascular imagingCoronary interventionTotal occlusionCTO-PCISingle-vessel chronic total occlusionSingle-vessel percutaneous coronary interventionCoronary chronic total occlusionsUse of IVUSLarge national analysisUse of OCTIVUS useOCT useCoherence tomographyLogistic regressionPatientsAbsolute numberCochran-ArmitageMortalityLess increaseInsight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement
Park D, Simonato M, Ahmad Y, Banks A, Lowenstern A, Nanna M. Insight Into the Optimal Timing of Percutaneous Coronary Intervention and Transcatheter Aortic Valve Replacement. Current Problems In Cardiology 2023, 49: 102050. PMID: 37643698, PMCID: PMC10924682, DOI: 10.1016/j.cpcardiol.2023.102050.Peer-Reviewed Original ResearchTranscatheter aortic valve replacementPercutaneous coronary artery interventionAcute kidney injuryAortic valve replacementKidney injuryValve replacementPercutaneous coronary interventionCoronary artery diseaseCoronary artery interventionPaucity of dataHospital mortalityNonhome dischargeCoronary interventionSecondary outcomesSelect patientsArtery diseaseArtery interventionClinical outcomesHigher oddsPCI timingPatientsReadmissionOptimal timingSame daySignificant differencesComparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression
Park D, An S, Jolly N, Attanasio S, Yadav N, Gutierrez J, Nanna M, Rao S, Vij A. Comparison of intravascular ultrasound, optical coherence tomography, and conventional angiography‐guided percutaneous coronary interventions: A systematic review, network meta‐analysis, and meta‐regression. Catheterization And Cardiovascular Interventions 2023, 102: 440-450. PMID: 37483068, PMCID: PMC10908343, DOI: 10.1002/ccd.30784.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPercutaneous coronary interventionOptical coherence tomographyCoronary angiographyIntravascular ultrasoundCoronary interventionCardiac deathClinical outcomesClinical efficacyConventional angiography-guided PCIAngiography-guided percutaneous coronary interventionCoherence tomographyUse of IVUSSuperiority of OCTAdverse cardiovascular eventsRandomized clinical trialsConventional coronary angiographyImaging modalitiesComparative clinical efficacyBest imaging modalityIntracoronary imaging modalityLesion revascularizationPCI guidanceCardiovascular eventsCause mortality
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